Patents by Inventor Victor A. Vinci

Victor A. Vinci has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Bioprocess for production of dipeptide based compounds
    Patent number: 6204008
    Abstract: Bioprocesses are disclosed for the production of compounds which can be produced from a dipeptide intermediate. The process comprises production of a recombinant polypeptide which contains the dipeptide intermediate. The dipeptide intermediate is further processed to ultimately provide the finished product.
    Type: Grant
    Filed: November 12, 1996
    Date of Patent: March 20, 2001
    Assignee: Merck & Co., Inc.
    Inventors: W. Scott Borneman, Anil Goyal, Michael J. Conder, Victor A. Vinci
  • DNA encoding triol polyketide synthase
    Patent number: 6174706
    Abstract: DNA encoding triol polyketide synthase (TPKS) has been isolated, purified and sequenced. Expression vectors comprising TPKS, cells transformed with the expression vectors, and processes employing the transformed cells are provided.
    Type: Grant
    Filed: January 8, 1998
    Date of Patent: January 16, 2001
    Assignee: Merck & Co., Inc.
    Inventors: Victor A. Vinci, Michael J. Conder, Phyllis C. McAda, Christopher D. Reeves, John Rambosek, Charles Ray Davis, Lee E. Hendrickson
  • DNA encoding triol polyketide synthase
    Patent number: 5849541
    Abstract: DNA encoding triol polyketide synthase (TPKS) from Aspergillus terreus has been isolated, purified and sequenced. Expression vectors comprising said DNA, cells transformed with the expression vectors, and processes employing the transformed cells are provided.
    Type: Grant
    Filed: August 23, 1996
    Date of Patent: December 15, 1998
    Assignee: Merck & Co., Inc.
    Inventors: Victor A. Vinci, Michael J. Conder, Phyllis C. McAda, Christopher D. Reeves, John Rambosek, Charles Ray Davis, Lee E. Hendrickson
  • DNA encoding triol polyketide synthase
    Patent number: 5744350
    Abstract: DNA encoding triol polyketide synthase (TPKS) has been isolated, purified and sequenced. Expression vectors comprising TPKS, cells transformed with the expression vectors, and processes employing the transformed cells are provided.
    Type: Grant
    Filed: May 25, 1995
    Date of Patent: April 28, 1998
    Assignee: Merck & Co., Inc.
    Inventors: Victor A. Vinci, Michael J. Conder, Phyllis C. McAda, Christopher D. Reeves, John Rambosek, Charles Ray Davis, Lee E. Hendrickson
  • Process for synthesis of acylated HMG-CoA reductase inhibitors from a lactone diol precursor using Candida cylindracea
    Patent number: 5420024
    Abstract: An immobilized lipase is employed in an organic solvent to esterify diol lactone derivatives of HMG-CoA reductase inhibitors to form HMG-CoA reductase inhibitors of formula (I). ##STR1## This process allows for the efficient, one-step production of HMG-CoA reductase inhibitors of structural formula (I).
    Type: Grant
    Filed: May 11, 1993
    Date of Patent: May 30, 1995
    Assignees: Merck & Co., Inc., The University of Virginia Alumni Patents Foundation
    Inventors: Giorgio Carta, Michael J. Conder, John L. Gainer, Robert W. Stieber, Victor A. Vinci, Timothy W. Weber
  • Mutant strains of Aspergillus terreus for producing 7-[1,2,6,7,8,8a(R)-hexa-hydro-2(S),6(R)-dimethyl-8(S)-hydroxy-1(S)-napht hyl]-3(R),5(R)-dihydroxyheptanoic acid (triol acid),I)
    Patent number: 5250435
    Abstract: Novel strains of Aspergillus terreus have been discovered which provide fermentation production of at least 5.2 g/L of 7-[1,2,6,7,8,8a(R)-hexahydro-2(S),6(R)-dimethyl-8(S)-hydroxy-1(S)-naphthyl ]-3(R),5(R)-dihydroxyheptanoic acid (triol acid, I), but with production of not more than 0.85 g/L of (triol acid)-related side products and specifically less than 0.10 mg/liter of lovastatin. The predominant fermentation product triol acid, may be converted in a straightforward manner to its lactone form, in which it is an inhibitor of HMG-CoA reductase and thus useful as an antihypercholesterolemic agent, and in which it may also serve as an intermediate for preparation of other HMG-CoA reductase inhibitors.
    Type: Grant
    Filed: June 4, 1991
    Date of Patent: October 5, 1993
    Assignee: Merck & Co., Inc.
    Inventors: William H. Cover, Rebecca L. Dabora, Anderson Hong, Christopher Reeves, Robert W. Stieber, Victor A. Vinci