Abstract: A hand-held molecular diagnostic test device includes a housing, an amplification (or PCR) module, and a detection module. The amplification module is configured to receive an input sample, and defines a reaction volume. The amplification module includes a heater such that the amplification module can perform a polymerase chain reaction (PCR) on the input sample. The detection module is configured to receive an output from the amplification module and a reagent formulated to produce a signal that indicates a presence of a target amplicon within the input sample. The amplification module and the detection module are integrated within the housing.

Abstract: A system for providing notifications to client devices that includes one or more processors and one or more storage devices. The storage devices may store instructions that, when executed, configure the processors to perform operations. The operations include receiving a transaction notification from a third party; identifying a user account associated with the transaction notification; generating a push notification with a payload describing instructions to display a message and an interactive icon, and a resource identifier associated with the interactive icon, where the resource identifier includes a message ID encoding an interactive session and an action ID encoding a requested action. The operations also include transmitting the push notification to a client device associated with the user account; receiving a first indication indicating a user interaction with the interactive icon, the first indication having the resource identifier and updating the user account based on the action request.

Abstract: Provided herein are KRAS G12C inhibitors, such as composition of the same, and methods of using the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.

Abstract: A system for providing notifications to client devices that includes one or more processors and one or more storage devices. The storage devices may store instructions that, when executed, configure the processors to perform operations. The operations include receiving a transaction notification from a third party; identifying a user account associated with the transaction notification; generating a push notification with a payload describing instructions to display a message and an interactive icon, and a resource identifier associated with the interactive icon, where the resource identifier includes a message ID encoding an interactive session and an action ID encoding a requested action. The operations also include transmitting the push notification to a client device associated with the user account; receiving a first indication indicating a user interaction with the interactive icon, the first indication having the resource identifier and updating the user account based on the action request.

Abstract: In one embodiment, in an information processing apparatus, comprising at least one computer processor, a Bot executed by the at least one computer processor may perform the following: (1) receiving invoice information for an invoice for a payor, the invoice information comprising an invoice amount and a due date; (2) electronically communicating a payment reminder comprising the invoice amount and the due date to the payor in a chat interface; and (3) providing a payment interface in the chat interface.

Abstract: In one embodiment, in an information processing apparatus, comprising at least one computer processor, a Bot executed by the at least one computer processor may perform the following: (1) receiving invoice information for an invoice for a payor, the invoice information comprising an invoice amount and a due date; (2) electronically communicating a payment reminder comprising the invoice amount and the due date to the payor in a chat interface; and (3) providing a payment interface in the chat interface.

Abstract: In one embodiment, in an information processing apparatus, comprising at least one computer processor, a Bot executed by the at least one computer processor may perform the following: (1) receiving invoice information for an invoice for a payor, the invoice information comprising an invoice amount and a due date; (2) electronically communicating a payment reminder comprising the invoice amount and the due date to the payor in a chat interface; and (3) providing a payment interface in the chat interface.

Abstract: Compositions and methods for detecting Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), influenza A, influenza B, and respiratory syncytial virus (RSV) are provided.

Abstract: Poly and perfluoroalkyl substances (PFAs) are extremely resistant to natural degradation. Described herein are compositions, assays, and methods for generating microorganisms capable of accelerating degradation of these products using a directed evolution strategy. A minimal media including the target carbon source of interest, creates selective pressure for microorganisms capable of degradation. Extremely slow growth rates on these alternative carbon sources is nevertheless measureable using automated image capture and processing pipeline allows one to observe very small changes in cell growth over the course of a very long period of time, thereby identifying microorganisms that could not otherwise be identified.

Abstract: A medicine container configured to hold one or more different medications. The container may include an orientation sensor to determine the orientation of the container. The container may also include one or more additional sensors to detect other physical characteristics about the container and/or medicine. The orientation of the container in combination with the information from the one or more additional sensors is used to determine an accurate indication of an amount of the medicine within the container and thus usage information. The container also includes a wireless transmitter for transmitting the information regarding the medicine to a remote location.

Abstract: In one embodiment, in an information processing apparatus, comprising at least one computer processor, a Bot executed by the at least one computer processor may perform the following: (1) receiving invoice information for an invoice for a payor, the invoice information comprising an invoice amount and a due date; (2) electronically communicating a payment reminder comprising the invoice amount and the due date to the payor in a chat interface; and (3) providing a payment interface in the chat interface.

Abstract: A medicine container configured to hold one or more different medications. The container may include an orientation sensor to determine the orientation of the container. The container may also include one or more additional sensors to detect other physical characteristics about the container and/or medicine. The orientation of the container in combination with the information from the one or more additional sensors is used to determine an accurate indication of an amount of the medicine within the container and thus usage information. The container also includes a wireless transmitter for transmitting the information regarding the medicine to a remote location.

Abstract: A medicine container configured to hold one or more different medications. The container may include an orientation sensor to determine the orientation of the container. The container may also include one or more additional sensors to detect other physical characteristics about the container and/or medicine. The orientation of the container in combination with the information from the one or more additional sensors is used to determine an accurate indication of an amount of the medicine within the container and thus usage information. The container also includes a wireless transmitter for transmitting the information regarding the medicine to a remote location.

Abstract: A bottle for storing medicine that may include at least one sensor to determine an aspect about the medicine stored within the bottle. The bottle may also include a processor that receives the information from the one or more sensors. A wireless communication interface may be integrated with the bottle to communicate information.

Abstract: Systems and methods for monitoring medication usage and adherence to one or more patients. One or more of adherence to the prescribed medication, adherence to dose times, and absolute adherence may be monitored. One or more patient entities may gain access to this information to further monitor the adherence of one or more patients.

Abstract: A bottle for storing medicine that may include at least one sensor to determine an aspect about the medicine stored within the bottle. The bottle may also include a processor that receives the information from the one or more sensors. A wireless communication interface may be integrated with the bottle to communicate information.

Abstract: A medicine container configured to hold one or more different medications. The container may include an orientation sensor to determine the orientation of the container. The container may also include one or more additional sensors to detect other physical characteristics about the container and/or medicine. The orientation of the container in combination with the information from the one or more additional sensors is used to determine an accurate indication of an amount of the medicine within the container and thus usage information. The container also includes a wireless transmitter for transmitting the information regarding the medicine to a remote location.

Abstract: Various embodiments pertain to techniques for utilizing confidence indicators to adjust bidding values used to obtain impression opportunities. In various embodiments, a system clusters a plurality of ad impression opportunities according to received information regarding each of the ad impression opportunities. Information about the clusters, referred to as data spots, is calculated and utilized to classify the data spots into one or more categories. Bidding strategies are assigned to each category. When the system receives an ad impression opportunity from an impression provider, the system identifies a data spot to which the received ad impression opportunity corresponds and determines a bid for the ad impression opportunity according to the bidding strategy assigned to the category into which the identified data spot is classified.

Abstract: A bottle for storing medicine that may include at least one sensor to determine an aspect about the medicine stored within the bottle. The bottle may also include a processor that receives the information from the one or more sensors. A wireless communication interface may be integrated with the bottle to communicate information.

Abstract: A label for a product includes an electronic display for displaying label information. The digital label includes an operating system program with an applications interface to allow development of custom applications by manufacturers, retailers, and users of the product. The digital label also includes a communications interface enable communication with external devices, such as other computer systems. The processor in the digital label can process, display, and transmit information.