Abstract: A microfluidic device includes a plurality of reagent sources for a feeding a plurality of reagents, each reagent source feeding a corresponding reagent among the plurality of reagents. A macro-chamber receives one or more reagents among the plurality of reagents from the plurality of reagent sources. A microfluidic reactor is coupled to the macro-chamber and the plurality of reagent sources and configured to receive one or more reagents among the plurality of reagents from at least one of the macro-chamber, the plurality of reagent sources, and react the one or more reagents to generate reaction content. The macro-chamber is further configured to receive the reaction content from the microfluidic reactor. A system configured to control at least one of flow of a dry gas in and out of the macro-chamber, surface area of at least one of the one or more reagents, and the reaction content in the macro-chamber.

Abstract: Techniques and devices are provided related to a handling system for cassettes for radiolabeled compound synthesis that include a magazine that is unshielded and that is configured to receive a plurality of microfluidic synthesis cassettes. In one embodiment, the plurality of microfluidic synthesis cassettes include nonradioactive reagents to generate a radiolabeled compound when reacted with a radioactive species. In this manner, a cassette handling device may be stored unshielded and may be coupled to a cassette handling platform to allow advancement of the plurality of microfluidic synthesis cassettes into the cassette handling platform and, in turn, a shielded radiosynthesis machine.

Abstract: A microfluidic chip includes a plurality of reagent sources for a feeding a plurality of reagents, each reagent source feeding a corresponding reagent among the plurality of reagents. A macro-chamber receives one or more reagents among the plurality of reagents from the plurality of reagent sources. A microfluidic reactor is coupled to the macro-chamber and the plurality of reagent sources and configured to receive two or more reagents among the plurality of reagents from at least one of the macro-chamber, the plurality of reagent sources, and react the two or more reagents to generate a reaction content.

Abstract: System and method for monitoring a synthesis process in a synthesizer to provide reduced quality control efforts and facilitate quality by design. The system and method perform by detecting a synthesizer parameter value for one or more synthesizer parameters of a radiopharmaceutical synthesis process in a radiopharmaceutical synthesizer, and comparing the synthesizer parameter value of each of the synthesizer parameters to a corresponding reference synthesizer value range. The radiopharmaceutical synthesis process is either continued, aborted, or interrupted based on a comparison result.

Abstract: Disclosed are devices and methods for reducing radiolysis of radiopharmaceuticals during filtration, concentration and purification. The devices comprises two or more confining geometry having a cross-section dimension below the beta(+) or beta(?) range of the radioisotope in use, when containing the radioisotope, and configured in such a way that neighboring geometries are isolated from its nearest neighbor such that no measurable kinetic positron energy transfer occurs between the confining geometries when containing the radioisotope. Methods of filtration of radioisotope containing mixtures are also disclosed.

Abstract: Disclosed are microfluidic devices and kits for containing radioisotopes. The devices and kits comprises at least one confining geometry having a cross-section dimension below the beta(+) or beta(?) range of a radioisotope, when containing the radioisotope configured in such a way that that neighboring segments of the confining geometries are isolated from its nearest neighbor such that no measurable kinetic positron energy transfer occurs between the segments when containing the radioisotope. Methods of storage and synthesis of radiopharmaceuticals are also disclosed. In another aspect, the present invention relates to methods of storing radiotracers and synthesizing radiopharmaceuticals, using the aforementioned device. The radiotracers and radiopharmaceuticals comprises 18F, 11C, 14C, 99mTc, 123I, 125I, 131I, 68Ga, 67Ga, 15O, 13N, 82Rb, 62Cu, 32P, 89Sr, 153Sm, 186Re, 201Tl, 111In, or combinations thereof.

Abstract: An interfacing cap for a reagent storage vessel is provided. The interfacing cap comprises a partitioning element having a structure corresponding to an opening of the reagent storage vessel, a projection fitting disposed on the partitioning element, a holder element, and a puncturing element coupled to the projection fitting.

Abstract: A fluid connector device is provided. The fluid connector device includes a coupling substrate having a conformal recess, a reconnectable fitting disposed in the recess to provide a first passageway, and a force applying element operatively coupled to the reconnectable fitting, or the coupling substrate, or both the reconnectable fitting and the coupling substrate to at least partially provide a sealing force between the reconnectable fitting and the coupling substrate, wherein at least one of the force applying element, the reconnectable fitting, and the coupling substrate comprises one or more degrees of freedom for self alignment of the reconnectable fitting and the conformal recess.

Abstract: A fluid connector device is provided. The fluid connector device comprises a coupling substrate comprising a conformal recess, a reconnectable fitting corresponding to the conformal recess, and a guiding device. The guiding device comprises a base component, a body at least partly disposed in the base component and comprising a broad end and a narrow end, wherein the broad end is disposed away from the coupling substrate, and wherein the body is slidably disposed in the base component, and a resilient component disposed on the body of the guiding device and configured to move the reconnectable fitting one or more degrees in a translational, or a rotational direction, or both, relative to the coupling substrate.

Abstract: Direct shaft power measurements of rotating machinery, including a magnetic encoding system for the shaft, having at least one conducting member having a first end and a second end which is disposed proximate the shaft with a gap between the member and the shaft. There is a pair of electrodes proximate each end of said conducting member, wherein the electrodes are electrically coupled to the shaft. One of the electrodes is electrically coupled to the second end of the conductor member. An encoding source is electrically coupled to the first end of the conducting member and electrically coupled to the other electrode, wherein unipolar current pulses from said encoding source are applied to the electrodes and the conducting member, thereby creating sectional encoded polarized magnetic regions in the shaft.

Abstract: Direct shaft power measurements of rotating machinery, including a magnetic encoding system for the shaft, having at least one conducting member having a first end and a second end which is disposed proximate the shaft with a gap between the member and the shaft. There is a pair of electrodes proximate each end of said conducting member, wherein the electrodes are electrically coupled to the shaft. One of the electrodes is electrically coupled to the second end of the conductor member. An encoding source is electrically coupled to the first end of the conducting member and electrically coupled to the other electrode, wherein unipolar current pulses from said encoding source are applied to the electrodes and the conducting member, thereby creating sectional encoded polarized magnetic regions in the shaft.

Abstract: The present invention provides a method of forming a branched structure which comprises applying colloidal-sized particles over structures. The coated structures are then etched such that the structures are etched through the colloidal particles to form branched structures. The etch may be a reactive ion etch. The structures may be microstructures formed as high aspect ratio microstructures. The colloidal-sized particles may be applied as a colloidal solution and a polyelectrolyte (PE) layer may be applied to the microstructures prior to the colloidal solution to promote adsorption of the colloidal particles.

Abstract: The present invention significantly reduces charging effects in electrostatic devices due to charge accumulation in or on the insulating materials on the active surfaces of the devices. This has been achieved by replacing the dielectric material that is normally present between the force generating conductor surfaces with a semi-insulating material. This semi-insulating film overcomes the effects of charging, while avoiding short-circuits when the surfaces are pulled into contact. It is not subject to insulation breakdown within the range of voltages used to operate the device. Examples of semi-insulating materials that may be used are semi-insulating polysilicon (SIPOS) and silicon rich silicon nitride.

Abstract: The present invention significantly reduces charging effects in electrostatic devices due to charge accumulation in or on the insulating materials on the active surfaces of the devices. This has been achieved by replacing the dielectric material that is normally present between the force generating conductor surfaces with a semi-insulating material. This semi-insulating film overcomes the effects of charging, while avoiding short-circuits when the surfaces are pulled into contact. It is not subject to insulation breakdown within the range of voltages used to operate the device. Examples of semi-insulating materials that may be used are semi-insulating polysilicon (SIPOS) and silicon rich silicon nitride.