Patents by Inventor Victor F. Ghetie

Victor F. Ghetie has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Ricin A chain mutants lacking enzymatic activity as vaccines to protect against aerosolized ricin
    Patent number: 8323665
    Abstract: The present invention provides methods to produce toxoid vaccines, such as ricin A chain vaccines, with reduced ability to promote vascular leak syndrome (VLS) and catalytic toxicity associated with various proteinaceous toxins, such as ribosome inactivating proteins. The invention also provides toxoids which have been mutated to lack amino acid sequences which induce VLS and toxic catalytic activity.
    Type: Grant
    Filed: February 12, 2007
    Date of Patent: December 4, 2012
    Assignee: The Board of Regents of the University of Texas System
    Inventors: Ellen S. Vitetta, Victor F. Ghetie, Joan E. Smallshaw, Roxana G. Baluna
  • RICIN A CHAIN MUTANTS LACKING ENZYMATIC ACTIVITY AS VACCINES TO PROTECT AGAINST AEROSOLIZED RICIN
    Publication number: 20120123097
    Abstract: The present invention provides methods to produce toxoid vaccines, such as ricin A chain vaccines, with reduced ability to promote vascular leak syndrome (VLS) and catalytic toxicity associated with various proteinaceous toxins, such as ribosome inactivating proteins. The invention also provides toxoids which have been mutated to lack amino acid sequences which induce VLS and toxic catalytic activity.
    Type: Application
    Filed: February 12, 2007
    Publication date: May 17, 2012
    Inventors: Ellen S. Vitetta, Victor F. Ghetie, Joan E. Smallshaw, Roxana G. Baluna
  • Compositions and methods for modifying toxic effects of proteinaceous compounds
    Patent number: 7829668
    Abstract: The present invention provides methods to produce immunotoxins (ITs) and cytokines with a reduced ability to promote vascular leak syndrome (VLS). The invention also provides ITs and cytokines which have been mutated to lack amino acid sequences which induce VLS. Also disclosed are methods for producing peptides that inhibit the induction of VLS by ITs and cytokines. Also disclosed are peptides comprising the (x)D(y) sequence to promote the extravasation of other molecules. Toxins mutated in the (x)D(y) motif or active site residues are disclosed for used in vaccines.
    Type: Grant
    Filed: May 19, 2003
    Date of Patent: November 9, 2010
    Assignee: Board of Regents, The University of Texas System
    Inventors: Ellen S. Vitetta, Victor F. Ghetie, Joan Elizabeth Smallshaw, Roxana G. Baluna
  • Compositions and methods for modifying toxic effects of proteinaceous compounds
    Patent number: 7452971
    Abstract: The present invention provides methods to produce immunotoxins (ITs) and cytokines with a reduced ability to promote vascular leak syndrome (VLS). The invention also provides ITs and cytokines which have been mutated to lack amino acid sequences which induce VLS.
    Type: Grant
    Filed: October 31, 2005
    Date of Patent: November 18, 2008
    Assignee: Board of Regents, The University of Texas System
    Inventors: Ellen S. Vitetta, Victor F. Ghetie, Joan E. Smallshaw, Roxana G. Baluna
  • Ricin A chain mutants lacking enzymatic activity as vaccines to protect against aerosolized ricin
    Patent number: 7175848
    Abstract: The present invention provides methods to produce toxoid vaccines, such as ricin A chain vaccines, with reduced ability to promote vascular leak syndrome (VLS) and catalytic toxicity associated with various proteinaceous toxins, such as ribosome inactivating proteins. The invention also provides toxoids which have been mutated to lack amino acid sequences which induce VLS and toxic catalytic activity.
    Type: Grant
    Filed: October 26, 2000
    Date of Patent: February 13, 2007
    Assignee: Board of Regents, The University of Texas System
    Inventors: Ellen S. Vitetta, Victor F. Ghetie, Joan E. Smallshaw, Roxana G. Baluna
  • Compositions and methods for modifying toxic effects of proteinaceous compounds
    Patent number: 6960652
    Abstract: The present invention provides methods to produce immunotoxins (ITs) and cytokines with a reduced ability to promote vascular leak syndrome (VLS). The invention also provides ITs and cytokines which have been mutated to lack amino acid sequences which induce VLS.
    Type: Grant
    Filed: October 29, 2002
    Date of Patent: November 1, 2005
    Assignee: Board of Regents, The University of Texas System
    Inventors: Ellen S. Vitetta, Victor F. Ghetie, Joan E. Smallshaw, Roxana G. Baluna
  • Compositions and methods for modifying toxic effects of proteinaceous compounds
    Publication number: 20040009148
    Abstract: The present invention provides methods to produce immunotoxins (ITs) and cytokines with a reduced ability to promote vascular leak syndrome (VLS). The invention also provides ITs and cytokines which have been mutated to lack amino acid sequences which induce VLS. Also disclosed are methods for producing peptides that inhibit the induction of VLS by ITs and cytokines. Also disclosed are peptides comprising the (x)D(y) sequence to promote the extravasation of other molecules. Toxins mutated in the (x)D(y) motif or active site residues are disclosed for used in vaccines.
    Type: Application
    Filed: May 19, 2003
    Publication date: January 15, 2004
    Inventors: Ellen S. Vitetta, Victor F. Ghetie, Joan Elizabeth Smallshaw, Roxana G. Baluna
  • Compositions and methods for modifying toxic effects of proteinaceous compounds
    Publication number: 20030143193
    Abstract: The present invention provides methods to produce immunotoxins (ITs) and cytokines with a reduced ability to promote vascular leak syndrome (VLS). The invention also provides ITs and cytokines which have been mutated to lack amino acid sequences which induce VLS.
    Type: Application
    Filed: October 29, 2002
    Publication date: July 31, 2003
    Inventors: Ellen S. Vitetta, Victor F. Ghetie, Joan E. Smallshaw, Roxana G. Baluna
  • Compositions and methods for modifying toxic effects of proteinaceous compounds
    Patent number: 6566500
    Abstract: The present invention provides methods to produce immunotoxins (ITs) and cytokines with a reduced ability to promote vascular leak syndrome (VLS). The invention also provides ITs and cytokines which have been mutated to lack amino acid sequences which induce VLS. Also disclosed are methods for producing peptides that inhibit the induction of VLS by ITs and cytokines. Also disclosed are peptides comprising the (x)D(y) sequence to promote the extravasation of other molecules. Toxins mutated in the (x)D(y) motif or active site residues are disclosed for used in vaccines.
    Type: Grant
    Filed: March 30, 2000
    Date of Patent: May 20, 2003
    Assignee: Board of Regents, The University of Texas System
    Inventors: Ellen S. Vitetta, Victor F. Ghetie, Joan Smallshaw, Roxana G. Baluna
  • Methods and compositions concerning homogenous immunotoxin preparations
    Patent number: 5578706
    Abstract: Immunotoxin preparations are described in which the preparations are enriched for a single species of immunotoxin. Also described are methods for the preparation of the substantially purified immunotoxins (ITs). Also disclosed are methods for determining the most effective species of immunotoxin conjugates for treated diseases and pharmaceutical preparations for such treatments.
    Type: Grant
    Filed: November 4, 1993
    Date of Patent: November 26, 1996
    Assignee: Board of Regents, The University of Texas
    Inventors: Victor F. Ghetie, Jonathan W. Uhr, Ellen S. Vitetta