Patents by Inventor Victor Fedij
Victor Fedij has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 10550087Abstract: Described are processes for the synthesis of certain compounds, useful for treating diseases, e.g. eye disease, such as glaucoma and ocular hypertension, in a subject.Type: GrantFiled: November 17, 2015Date of Patent: February 4, 2020Assignee: Aerie Pharmaceuticals, Inc.Inventors: Jill Marie Sturdivant, Mitchell A. deLong, Gilles Chambournier, Michael G. Pamment, Victor Fedij
-
Publication number: 20200002261Abstract: The present invention provides processes for preparing a prostacyclin analogue of Formula I or a pharmaceutically acceptable salt thereof, wherein R10 is a linear or branched C1-6 alkyl. The processes of the present invention comprise steps that generate improved yields and fewer byproducts than traditional methods. The processes of the present invention employ reagents (e.g., the oxidizing reagent) that are less toxic that those used in the traditional methods (e.g., oxalyl chloride). Many of the processes of the present invention generate intermediates with improved e.e. and chemical purity; thereby eliminating the need of additional chromatography steps. And, the processes of the present invention are scalable to generate commercial quantities of the final compound.Type: ApplicationFiled: September 11, 2019Publication date: January 2, 2020Applicant: CAYMAN CHEMICAL COMPANY INCORPORATEDInventors: Kirk William Hering, Gilles CHAMBOURNIER, Gregory William ENDRES, Victor FEDIJ, Thomas James KRELL, II, Hussien Mahmoud MAHMOUD
-
Patent number: 10450257Abstract: The present invention provides processes for preparing a prostacyclin analog of Formula I or a pharmaceutically acceptable salt thereof, wherein R10 is a linear or branched C1-6 alkyl. The processes of the present invention comprise steps that generate improved yields and fewer byproducts than traditional methods. The processes of the present invention employ reagents (e.g., the oxidizing reagent) that are less toxic that those used in the traditional methods (e.g., oxalyl chloride). Many of the processes of the present invention generate intermediates with improved e.e. and chemical purity; thereby eliminating the need of additional chromatography steps. And, the processes of the present invention are scalable to generate commercial quantities of the final compound.Type: GrantFiled: January 18, 2018Date of Patent: October 22, 2019Assignee: Cayman Chemical Company IncorporatedInventors: Kirk William Hering, Gilles Chambournier, Gregory William Endres, Victor Fedij, Thomas James Krell, II, Hussein Mahmoud Mahmoud
-
Publication number: 20180370919Abstract: Described are processes for the synthesis of certain compounds, useful for treating diseases, e.g. eye disease, such as glaucoma and ocular hypertension, in a subject.Type: ApplicationFiled: November 17, 2015Publication date: December 27, 2018Inventors: Jill Marie Sturdivant, Mitchell A. deLong, Gilles Chambournier, Michael G. Pamment, Victor Fedij
-
Patent number: 10155716Abstract: The present invention provides amine salts of the prostacyclin analogue of Formula I and processes for generating these amine salts.Type: GrantFiled: December 22, 2017Date of Patent: December 18, 2018Assignee: Cayman Chemical Company IncorporatedInventors: Gilles Chambournier, Gregory William Endres, Kirk William Hering, Victor Fedij, Hussein Mahmoud Mahmoud
-
Publication number: 20180141889Abstract: The present invention provides processes for preparing a prostacyclin analogue of Formula I or a pharmaceutically acceptable salt thereof, wherein R10 is a linear or branched C1-6 alkyl. The processes of the present invention comprise steps that generate improved yields and fewer byproducts than traditional methods. The processes of the present invention employ reagents (e.g., the oxidizing reagent) that are less toxic that those used in the traditional methods (e.g., oxalyl chloride). Many of the processes of the present invention generate intermediates with improved e.e. and chemical purity; thereby eliminating the need of additional chromatography steps. And, the processes of the present invention are scalable to generate commercial quantities of the final compound.Type: ApplicationFiled: January 18, 2018Publication date: May 24, 2018Applicant: CAYMAN CHEMICAL COMPANY INCORPORATEDInventors: Kirk William Hering, Gilles Chambournier, Gregory William Endres, Victor Fedij, Thomas James Krell, II, Hussein Mahmoud Mahmoud
-
Publication number: 20180118656Abstract: The present invention provides amine salts of the prostacyclin analogue of Formula I and processes for generating these amine salts.Type: ApplicationFiled: December 22, 2017Publication date: May 3, 2018Applicant: Cayman Chemical Company IncorporatedInventors: Gilles Chambournier, Gregory William Endres, Kirk William Hering, Victor Fedij, Hussein Mahmoud Mahmoud
-
Patent number: 9908834Abstract: The present invention provides processes for preparing a prostacyclin analog of Formula (I) or a pharmaceutically acceptable salt thereof, wherein R10 is a linear or branched C1-6 alkyl. The processes of the present invention comprise steps that generate improved yields and fewer byproducts than traditional methods. The processes of the present invention employ reagents (e.g., the oxidizing reagent) that are less toxic that those used in the traditional methods (e.g., oxalyl chloride). Many of the processes of the present invention generate intermediates with improved e.e. and chemical purity; thereby eliminating the need of additional chromatography steps. And, the processes of the present invention are scalable to generate commercial quantities of the final compound.Type: GrantFiled: May 1, 2017Date of Patent: March 6, 2018Assignee: Cayman Chemical Company IncorporatedInventors: Kirk William Hering, Gilles Chambournier, Gregory William Endres, Victor Fedij, Thomas James Krell, II, Hussein Mahmoud Mahmoud
-
Patent number: 9890104Abstract: The present invention provides amine salts of the prostacyclin analogue of Formula I and processes for generating these amine salts.Type: GrantFiled: November 7, 2014Date of Patent: February 13, 2018Assignee: Cayman Chemical Company IncorporatedInventors: Gilles Chambournier, Gregory William Endres, Kirk William Hering, Victor Fedij, Hussein Mahmoud Mahmoud
-
Publication number: 20170297995Abstract: The present invention provides processes for preparing a prostacyclin analogue of Formula (I) or a pharmaceutically acceptable salt thereof, wherein R10 is a linear or branched C1-6 alkyl. The processes of the present invention comprise steps that generate improved yields and fewer byproducts than traditional methods. The processes of the present invention employ reagents (e.g., the oxidizing reagent) that are less toxic that those used in the traditional methods (e.g., oxalyl chloride). Many of the processes of the present invention generate intermediates with improved e.e. and chemical purity; thereby eliminating the need of additional chromatography steps. And, the processes of the present invention are scalable to generate commercial quantities of the final compound.Type: ApplicationFiled: May 1, 2017Publication date: October 19, 2017Applicant: CAYMAM CHEMICAL COMPANY INCORPORATEDInventors: Kirk William Hering, Gilles Chambournier, Gregory William Endres, Victor Fedij, Thomas James Krell, II, Hussein Mahmoud Mahmoud
-
Publication number: 20170137384Abstract: Described are processes for the synthesis of certain compounds, useful for treating diseases, e.g. eye disease, such as glaucoma and ocular hypertension, in a subject.Type: ApplicationFiled: November 17, 2015Publication date: May 18, 2017Inventors: Jill M. Sturdivant, Mitchell A. deLong, Gilles Chambournier, Michael G. Pamment, Victor Fedij
-
Patent number: 9643927Abstract: Described are processes for the synthesis of certain compounds, useful for treating diseases, e.g. eye disease, such as glaucoma and ocular hypertension, in a subject.Type: GrantFiled: November 17, 2015Date of Patent: May 9, 2017Assignee: Aerie Pharmaceuticals, Inc.Inventors: Jill M. Sturdivant, Mitchell A. deLong, Gilles Chambournier, Michael G. Pamment, Victor Fedij
-
Publication number: 20160289158Abstract: The present invention provides amine salts of the prostacyclin analogue of Formula I and processes for generating these amine salts.Type: ApplicationFiled: November 7, 2014Publication date: October 6, 2016Applicant: CAYMAN CHEMICAL COMPANY INCORPORATEDInventors: GILLES CHAMBOURNIER, GREGORY WILLIAM ENDRES, KIRK WILLIAM HERING, VICTOR FEDIJ, HUSSEIN MAHMOUD MAHMOUD
-
Publication number: 20150315114Abstract: The present invention provides processes for preparing a prostacyclin analogue of Formula (I) or a pharmaceutically acceptable salt thereof, wherein R10 is a linear or branched C1-6 alkyl. The processes of the present invention comprise steps that generate improved yields and fewer byproducts than traditional methods. The processes of the present invention employ reagents (e.g., the oxidizing reagent) that are less toxic that those used in the traditional methods (e.g., oxalyl chloride). Many of the processes of the present invention generate intermediates with improved e.e. and chemical purity; thereby eliminating the need of additional chromatography steps. And, the processes of the present invention are scalable to generate commercial quantities of the final compound.Type: ApplicationFiled: December 6, 2013Publication date: November 5, 2015Inventors: Kirk Willam HERING, Gilles CHAMBOURNIER, Gregory William ENDRES, Victor FEDIJ, Thomas James KRELL, II, Hussein Mahmoud MAHMOUD
-
Patent number: 7799823Abstract: The present invention is directed to a new class of benzonitriles and to their use as androgen receptor modulators. Other aspects of the invention are directed to the use of these compounds to decrease excess sebum secretions and to stimulate hair growth.Type: GrantFiled: November 7, 2006Date of Patent: September 21, 2010Assignee: Warner-Lambert Company LLCInventors: Stephen Douglas Barrett, Victor Fedij, Lain-Yen Hu, Donna M Iula, Bruce A Lefker, Raj Kumar Raheja, Karen Sexton, Jennifer Ann Van Camp
-
Patent number: 7674819Abstract: The present invention is directed to a new class of benzonitriles and to their use as androgen receptor modulators. Other aspects of the invention are directed to the use of these compounds to decrease excess sebum secretions and to stimulate hair growth.Type: GrantFiled: May 2, 2006Date of Patent: March 9, 2010Assignee: Warner-Lambert Company LLCInventors: Stephen Douglas Barrett, Victor Fedij, Lain-Yen Hu, Donna M. Iula, Bruce A. Lefker, Raj Kumar Raheja, Karen Sexton, Jennifer Ann Van Camp
-
Publication number: 20090192202Abstract: The present invention is directed to a new class of 4-cyano-phenoxy-alkyl carboxyl derivatives and to their use as androgen receptor modulators. Other aspects of the invention are directed to the use of these compounds to decrease excess sebum secretions and to stimulate hair growth.Type: ApplicationFiled: February 9, 2009Publication date: July 30, 2009Inventors: Lain-Yen Hu, Huangshu Lei, Daniel Y. Du, Bruce A. Lefker, Yvonne Dorothy Smith, Victor Fedij
-
Patent number: 7507860Abstract: The present invention is directed to a new class of 4-cyano-phenoxy-alkyl carboxyl derivatives and to their use as androgen receptor modulators. Other aspects of the invention are directed to the use of these compounds to decrease excess sebum secretions and to stimulate hair growth.Type: GrantFiled: April 1, 2005Date of Patent: March 24, 2009Assignee: Pfizer Inc.Inventors: Lain-Yen Hu, Huangshu Lei, Daniel Y. Du, Bruce A. Lefker, Yvonne Dorothy Smith, Victor Fedij
-
Publication number: 20070197641Abstract: The present invention is directed to a new class of 4-cyano-phenoxy-alkyl carboxyl derivatives and to their use as androgen receptor modulators. Other aspects of the invention are directed to the use of these compounds to decrease excess sebum secretions and to stimulate hair growth.Type: ApplicationFiled: April 1, 2005Publication date: August 23, 2007Inventors: Lain-Yen Hu, Huangshu Lei, Daniel Du, Bruce Lefker, Yvonne Smith, Victor Fedij
-
Publication number: 20070072936Abstract: The present invention is directed to a new class of benzonitriles and to their use as androgen receptor modulators. Other aspects of the invention are directed to the use of these compounds to decrease excess sebum secretions and to stimulate hair growth.Type: ApplicationFiled: November 7, 2006Publication date: March 29, 2007Applicant: WARNER-LAMBERT COMPANY LLCInventors: Stephen Barrett, Victor Fedij, Lain-Yen Hu, Donna Iula, Bruce Lefker, Raj Raheja, Karen Sexton, Jennifer Van Camp