Abstract: A method of improving a neurodegenerative or cognitive disorder in a human patient suffering therefrom is provided by determining a target site of the human patient's brain that is affected by the neurodegenerative disorder or cognitive disorder and providing a therapy to the human patient. The therapy includes applying a low intensity focused ultrasound (LiFUS) sonication via an ultrasound delivery device to the target site based on an imaging parameter, a microbubble cavitation; an optical parameter, a bodily fluid parameter, or a physiological or anatomical parameter of the human patient's brain. A therapeutic agent is introduced to the target site before, after or during application of the LiFUS sonication.

Abstract: A method of improving a neurodegenerative or cognitive disorder in a human patient suffering therefrom is provided by determining a target site of the human patient's brain that is affected by the neurodegenerative disorder or cognitive disorder and providing a therapy to the human patient. The therapy includes applying a low intensity focused ultrasound (LiFUS) sonication via an ultrasound delivery device to the target site based on an imaging parameter, a microbubble cavitation; an optical parameter, a bodily fluid parameter, or a physiological or anatomical parameter of the human patient's brain. A therapeutic agent is introduced to the target site before, after or during application of the LiFUS sonication.

Abstract: Systems and methods are provided for generating a clinical parameter for a user. A first plurality of wellness-relevant parameters representing the user are monitored at a physiological sensing device over a defined period. A second plurality of wellness-relevant parameters representing the user are obtained via a portable computing device. A third plurality of wellness-relevant parameters representing the user are retrieved from an electronic health records (EHR) system. A set of aggregate parameters are generated from the sets of wellness-relevant parameters, with each of the set of aggregate parameters comprising a unique proper subset of the parameters in the sets of wellness-relevant parameters. A clinical parameter is assigned to the user via a predictive model according to a subset of the set of aggregate parameters. An intervention is provided to the user when the clinical parameter meets a threshold value specific to the patient.

Abstract: Methods of improving addiction in a patient in need thereof are provided. Methods include exposing the patient to drug related cues and measuring the patient's craving levels or physiological levels during or after cue exposure to determine the patient's status or condition. Such a determination can indicate whether the patient is at risk of engaging in the addictive activity and can guide therapeutic intervention.

Abstract: Systems and methods are provided for targeting neuromodulation. A first image, representing a structure of the brain, is acquired from a first imaging system and a second image, representing a connectivity of the brain, is acquired from either the first imaging system or a second imaging system. A first utility value associated with directly modulating tissue within a region of interest is determined for each of a plurality of voxels within the region of interest from the first image. A second utility value associated with indirectly modulating tissue outside of the region of interest by modulating tissue within the region of interest is determined for each of the plurality of voxels from the second image. An overall utility value for each of the plurality of voxels is determined from the first utility value and the second utility value, and an optimal location is determined from the overall utility values.

Abstract: Methods of improving addiction in a patient in need thereof are provided. Methods include exposing the patient to drug related cues and measuring the patient's craving levels or physiological levels during or after cue exposure to determine the patient's status or condition. Such a determination can indicate whether the patient is at risk of engaging in the addictive activity and can guide therapeutic intervention.

Abstract: Methods of improving addiction in a patient in need thereof are provided. Methods include exposing the patient to drug related cues and measuring the patient's craving levels or physiological levels during or after cue exposure to determine the patient's status or condition. Such a determination can indicate whether the patient is at risk of engaging in the addictive activity and can guide therapeutic intervention.

Abstract: Systems and methods are disclosed for providing focused ultrasound treatment. A patient is screened to determine if focused ultrasound treatment is appropriate for the patient to treat a disorder. The patient is monitored to measure a plurality of wellness-related parameters for the patient and detect or predict an onset of symptoms associated with the disorder from the wellness-related parameters if focused ultrasound treatment has been determined to be appropriate. A personalized location for focused ultrasound treatment is determined for the patient according to at least one of the wellness-related parameters. At least one parameter associated with the focused ultrasound treatment is selected according to at least one of the wellness-related parameters. Focused ultrasound treatment is provided to the patient at the selected location using the selected at least one parameter.

Abstract: Systems and methods are provided for evaluating pain for a user. A first pain-relevant parameter representing the user is monitored at an in-vivo sensing device over a defined period to produce a time series for the first pain-relevant parameter. A value for a second pain-relevant parameter for the user is obtained at first and second times in the defined period from the user via a portable computing device to provide respective first and second values for the second pain-relevant parameter. A value is assigned to the user via a predictive model according to the time series for the first pain-relevant parameter, the first value for the second pain-relevant parameter, and the second value for the second pain-relevant parameter.

Abstract: Systems and methods are provided for monitoring a wellness of a user. A wellness-relevant parameter representing the user is monitored at a portable device over a defined period to produce a time series for the wellness-relevant parameter. A first set and a second set of either cognitive assessment data or psychosocial assessment data are obtained for the user at respective first and second times in the defined period. A value is assigned to the user via a predictive model according to the time series for the wellness-relevant parameter, the first set of either cognitive assessment data or psychosocial assessment data, and the second set of either cognitive assessment data or psychosocial assessment data.

Abstract: Methods of improving ARDS by regulating a stellate ganglion is provided herein. Methods of improving a hypercoagulation state are also provided by regulating the sympathetic nervous system.

Abstract: Methods of improving addiction in a patient in need thereof are provided. Methods include exposing the patient to drug related cues and measuring the patient's craving levels or physiological levels during or after cue exposure to determine the patient's status or condition. Such a determination can indicate whether the patient is at risk of engaging in the addictive activity and can guide therapeutic intervention.

Abstract: Methods of improving addiction in a patient in need thereof are provided. Methods include using focused ultrasound, deep brain stimulation and/or transcranial magnetic stimulation and multi-dimensional monitoring of the patient to determine whether the focused ultrasound, deep brain stimulation, and/or transcranial magnetic stimulation improves the patient's addiction. Based on this determination, the focused ultrasound, deep brain stimulation, and/or transcranial magnetic stimulation can be adjusted to improve the patient's addiction.