Patents by Inventor Victor H. Yee
Victor H. Yee has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20190194765Abstract: Systems and methods for detecting and/or identifying target cells (e.g., bacteria) using engineered transduction particles are described herein. In some embodiments, a method includes mixing a quantity of transduction particles within a sample. The transduction particles are associated with a target cell. The transduction particles are non-replicative, and are engineered to include a nucleic acid molecule formulated to cause the target cell to produce a series of reporter molecules. The sample and the transduction particles are maintained to express the series of the reporter molecules when target cell is present in the sample. A signal associated with a quantity of the reporter molecules is received. In some embodiments, a magnitude of the signal is independent from a quantity of the transduction particle above a predetermined quantity.Type: ApplicationFiled: February 27, 2019Publication date: June 27, 2019Applicant: GeneWeave Biosciences, Inc.Inventors: Diego Ariel REY, Shaunak ROY, Leonardo Maestri TEIXEIRA, Ryan C. GRISWOLD, Kenneth G. OLSON, Bruce J. RICHARDSON, Victor H. YEE, Werner FREI
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Patent number: 10240212Abstract: Systems and methods for detecting and/or identifying target cells (e.g., bacteria) using engineered transduction particles are described herein. In some embodiments, a method includes mixing a quantity of transduction particles within a sample. The transduction particles are associated with a target cell. The transduction particles are non-replicative, and are engineered to include a nucleic acid molecule formulated to cause the target cell to produce a series of reporter molecules. The sample and the transduction particles are maintained to express the series of the reporter molecules when target cell is present in the sample. A signal associated with a quantity of the reporter molecules is received. In some embodiments, a magnitude of the signal is independent from a quantity of the transduction particle above a predetermined quantity.Type: GrantFiled: December 22, 2016Date of Patent: March 26, 2019Assignee: GeneWeave Biosciences, Inc.Inventors: Diego Ariel Rey, Shaunak Roy, Leonardo Maestri Teixeira, Ryan C. Griswold, Kenneth G. Olson, Bruce J. Richardson, Victor H. Yee, Werner Frei
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Patent number: 10125386Abstract: An apparatus includes a housing and an actuator. The housing, which defines a reagent volume that can receive a reagent container, can be removably coupled to a reaction chamber. The housing includes a puncturer that defines a transfer pathway in fluid communication with the reagent volume. A delivery portion of the housing defines a delivery pathway between the transfer pathway and the reaction chamber when the housing is coupled to the reaction chamber. The actuator has a plunger portion disposed within the reagent volume. An engagement portion of the actuator can be manipulated to move the plunger portion within the reagent volume to deform the reagent container. The puncturer can pierce a frangible portion of the reagent container to convey a reagent from the reagent container into the reaction chamber via the transfer pathway and/or the delivery pathway.Type: GrantFiled: November 30, 2016Date of Patent: November 13, 2018Assignee: GeneWeave Biosciences, Inc.Inventors: Nikol De Forest, Werner Frei, Diego Rey, Shaunak Roy, Soni Shukla, Ryan C. Griswold, Kenneth G. Olson, Bruce J. Richardson, Victor H. Yee
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Publication number: 20170233783Abstract: An apparatus includes a housing and an actuator. The housing, which defines a reagent volume that can receive a reagent container, can be removably coupled to a reaction chamber. The housing includes a puncturer that defines a transfer pathway in fluid communication with the reagent volume. A delivery portion of the housing defines a delivery pathway between the transfer pathway and the reaction chamber when the housing is coupled to the reaction chamber. The actuator has a plunger portion disposed within the reagent volume. An engagement portion of the actuator can be manipulated to move the plunger portion within the reagent volume to deform the reagent container. The puncturer can pierce a frangible portion of the reagent container to convey a reagent from the reagent container into the reaction chamber via the transfer pathway and/or the delivery pathway.Type: ApplicationFiled: November 30, 2016Publication date: August 17, 2017Applicant: GeneWeave Biosciences, Inc.Inventors: Nikol DE FOREST, Werner FREI, Diego Rey, Shaunak Roy, Soni SHUKLA, Ryan C. GRISWOLD, Kenneth G. OLSON, Bruce J. RICHARDSON, Victor H. Yee
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Publication number: 20170225162Abstract: A microplate assembly for performing an analytical method on an assay, comprising a microplate base structure having a plurality of apertures formed therethrough, and a plurality of well inserts coupled to the microplate base structure adjacent the apertures. Each of the plurality of well inserts has an open top portion and is adapted to receive an assay. The microplate base structure and the plurality of well inserts can comprise different materials. Methods of manufacturing the microplate assembly are also provided.Type: ApplicationFiled: April 24, 2017Publication date: August 10, 2017Inventors: David M. Liu, Gary Lim, Victor H. Yee
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Publication number: 20170152576Abstract: Systems and methods for detecting and/or identifying target cells (e.g., bacteria) using engineered transduction particles are described herein. In some embodiments, a method includes mixing a quantity of transduction particles within a sample. The transduction particles are associated with a target cell. The transduction particles are non-replicative, and are engineered to include a nucleic acid molecule formulated to cause the target cell to produce a series of reporter molecules. The sample and the transduction particles are maintained to express the series of the reporter molecules when target cell is present in the sample. A signal associated with a quantity of the reporter molecules is received. In some embodiments, a magnitude of the signal is independent from a quantity of the transduction particle above a predetermined quantity.Type: ApplicationFiled: December 22, 2016Publication date: June 1, 2017Applicant: GeneWeave Biosciences, Inc.Inventors: Diego Ariel REY, Shaunak ROY, Leonardo Maestri TEIXEIRA, Ryan C. GRISWOLD, Kenneth G. OLSON, Bruce J. RICHARDSON, Victor H. YEE
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Patent number: 9546391Abstract: Systems and methods for detecting and/or identifying target cells (e.g., bacteria) using engineered transduction particles are described herein. In some embodiments, a method includes mixing a quantity of transduction particles within a sample. The transduction particles are associated with a target cell. The transduction particles are non-replicative, and are engineered to include a nucleic acid molecule formulated to cause the target cell to produce a series of reporter molecules. The sample and the transduction particles are maintained to express the series of the reporter molecules when target cell is present in the sample. A signal associated with a quantity of the reporter molecules is received. In some embodiments, a magnitude of the signal is independent from a quantity of the transduction particle above a predetermined quantity.Type: GrantFiled: September 8, 2014Date of Patent: January 17, 2017Assignee: GeneWeave Biosciences, Inc.Inventors: Diego Ariel Rey, Shaunak Roy, Werner Frei, Bruce J. Richardson, Ryan C. Griswold, Damian S. Matthews, Kenneth G. Olson, Victor H. Yee
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Patent number: 9540675Abstract: An apparatus includes a housing and an actuator. The housing, which defines a reagent volume that can receive a reagent container, can be removably coupled to a reaction chamber. The housing includes a puncturer that defines a transfer pathway in fluid communication with the reagent volume. A delivery portion of the housing defines a delivery pathway between the transfer pathway and the reaction chamber when the housing is coupled to the reaction chamber. The actuator has a plunger portion disposed within the reagent volume. An engagement portion of the actuator can be manipulated to move the plunger portion within the reagent volume to deform the reagent container. The puncturer can pierce a frangible portion of the reagent container to convey a reagent from the reagent container into the reaction chamber via the transfer pathway and/or the delivery pathway.Type: GrantFiled: February 9, 2015Date of Patent: January 10, 2017Assignee: GeneWeave Biosciences, Inc.Inventors: Nikol De Forest, Werner Frei, Diego Rey, Shaunak Roy, Soni Shukla, Ryan C. Griswold, Kenneth G. Olson, Bruce J. Richardson, Victor H. Yee
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Publication number: 20150218613Abstract: An apparatus includes a housing and an actuator. The housing, which defines a reagent volume that can receive a reagent container, can be removably coupled to a reaction chamber. The housing includes a puncturer that defines a transfer pathway in fluid communication with the reagent volume. A delivery portion of the housing defines a delivery pathway between the transfer pathway and the reaction chamber when the housing is coupled to the reaction chamber. The actuator has a plunger portion disposed within the reagent volume. An engagement portion of the actuator can be manipulated to move the plunger portion within the reagent volume to deform the reagent container. The puncturer can pierce a frangible portion of the reagent container to convey a reagent from the reagent container into the reaction chamber via the transfer pathway and/or the delivery pathway.Type: ApplicationFiled: February 9, 2015Publication date: August 6, 2015Applicant: GeneWeave Biosciences, Inc.Inventors: Nikol DE FOREST, Werner FREI, Diego REY, Shaunak ROY, Soni SHUKLA, Ryan C. GRISWOLD, Kenneth G. OLSON, Bruce J. RICHARDSON, Victor H. YEE
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Publication number: 20150132795Abstract: Systems and methods for detecting and/or identifying target cells (e.g., bacteria) using engineered transduction particles are described herein. In some embodiments, a method includes mixing a quantity of transduction particles within a sample. The transduction particles are associated with a target cell. The transduction particles are non-replicative, and are engineered to include a nucleic acid molecule formulated to cause the target cell to produce a series of reporter molecules. The sample and the transduction particles are maintained to express the series of the reporter molecules when target cell is present in the sample. A signal associated with a quantity of the reporter molecules is received. In some embodiments, a magnitude of the signal is independent from a quantity of the transduction particle above a predetermined quantity.Type: ApplicationFiled: September 8, 2014Publication date: May 14, 2015Applicant: GeneWeave Biosciences, Inc.Inventors: Ryan C. GRISWOLD, Bruce J. RICHARDSON, Rick V. STELLMACHER, Victor H. YEE
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Publication number: 20140273180Abstract: Systems and methods for detecting and/or identifying target cells (e.g., bacteria) using engineered transduction particles are described herein. In some embodiments, a method includes mixing a quantity of transduction particles within a sample. The transduction particles are associated with a target cell. The transduction particles are non-replicative, and are engineered to include a nucleic acid molecule formulated to cause the target cell to produce a series of reporter molecules. The sample and the transduction particles are maintained to express the series of the reporter molecules when target cell is present in the sample. A signal associated with a quantity of the reporter molecules is received. In some embodiments, a magnitude of the signal is independent from a quantity of the transduction particle above a predetermined quantity.Type: ApplicationFiled: October 8, 2013Publication date: September 18, 2014Applicant: GENEWEAVE BIOSCIENCES, INC.Inventors: Ryan C. GRISWOLD, Kenneth G. OLSON, Bruce J. RICHARDSON, Rick V. STELLMACHER, Victor H. YEE
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Patent number: 8829473Abstract: Systems and methods for detecting and/or identifying target cells (e.g., bacteria) using engineered transduction particles are described herein. In some embodiments, a method includes mixing a quantity of transduction particles within a sample. The transduction particles are associated with a target cell. The transduction particles are non-replicative, and are engineered to include a nucleic acid molecule formulated to cause the target cell to produce a series of reporter molecules. The sample and the transduction particles are maintained to express the series of the reporter molecules when target cell is present in the sample. A signal associated with a quantity of the reporter molecules is received. In some embodiments, a magnitude of the signal is independent from a quantity of the transduction particle above a predetermined quantity.Type: GrantFiled: October 8, 2013Date of Patent: September 9, 2014Assignee: GeneWeave Biosciences, Inc.Inventors: Ryan C. Griswold, Kenneth G. Olson, Bruce J. Richardson, Rick V. Stellmacher, Victor H. Yee
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Publication number: 20110300037Abstract: A microplate assembly for performing an analytical method on an assay, comprising a microplate base structure having a plurality of apertures formed therethrough, and a plurality of well inserts coupled to the microplate base structure adjacent the apertures. Each of the plurality of well inserts has an open top portion and is adapted to receive an assay. The microplate base structure and the plurality of well inserts can comprise different materials. Methods of manufacturing the microplate assembly are also provided.Type: ApplicationFiled: April 20, 2011Publication date: December 8, 2011Applicant: LIFE TECHNOLOGIES CORPORATIONInventors: David M. Liu, Gary Lim, Victor H. Yee
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Publication number: 20090004064Abstract: A microplate assembly for performing an analytical method on an assay, comprising a microplate base structure having a plurality of apertures formed therethrough, and a plurality of well inserts coupled to the microplate base structure adjacent the apertures. Each of the plurality of well inserts has an open top portion and is adapted to receive an assay. The microplate base structure and the plurality of well inserts can comprise different materials. Methods of manufacturing the microplate assembly are also provided.Type: ApplicationFiled: June 25, 2008Publication date: January 1, 2009Applicant: Applera CorporationInventors: David M. Liu, Gary Lim, Victor H. Yee
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Patent number: 4837822Abstract: The present invention relates to electronic locks and electronic locking systems, to electronic locking systems which use remotely encoded keycards and, in particular, to an electronic locking system which utilizes public key cryptography.Type: GrantFiled: April 8, 1986Date of Patent: June 6, 1989Assignee: Schlage Lock CompanyInventors: Thomas W. Crosley, Wayne Davison, James R. Goldberg, Leonard L. Hofheins, Ronald D. Lichty, Charles A. Vollum, Stephen H. Vollum, Victor H. Yee
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Patent number: 4749072Abstract: Disclosed is a clutch mechanism suitable for use in an electronic lock. The clutch mechanism requires minimum electronic current draw for operation by utilizing mechanical power applied to operate the lock to engage the clutch mechanism. A camming device in combination with a timed function motion sensor and latching solenoid released interference shutter accomplishes the object of the invention.Type: GrantFiled: April 29, 1987Date of Patent: June 7, 1988Assignee: Schlage Lock CompanyInventors: Ronald D. Lichty, Thomas W. Crosley, Victor H. Yee