Patents by Inventor Victor I. Reus

Victor I. Reus has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods of compositions for diagnosing and treating chromosome-18p related disorders
    Publication number: 20040176572
    Abstract: The present invention relates to the mammalian HKNG1 gene, a gene associated with bipolar affective disorder (BAD) in humans. The invention relates, in particular, to methods for the diagnostic evaluation, genetic testing and prognosis of HKNG1 neuropsychiatric disorders including schizophrenia, attention deficit disorder, a schizoaffective disorder, a bipolar affective disorder or a unipolar affective disorder.
    Type: Application
    Filed: July 28, 2003
    Publication date: September 9, 2004
    Inventors: Nelson B. Freimer, Victor I. Reus, Susan K. Service, Lynne Allison McInnes, Hong Chen, Pedro Leon, Lodewijk A. Sandkuijl, L. Sandkuijl-Schakenbos
  • Methods for treating bipolar mood disorder associated with markers on chromosome 18p
    Patent number: 6750010
    Abstract: The present invention is directed to methods of detecting the presence of a bipolar mood disorder susceptibility locus in an individual, comprising analyzing a sample of DNA for the presence of a DNA polymorphism on the short arm of chromosome 18 between the telomere and D18S481, wherein the DNA polymorphism is associated with a form of bipolar mood disorder. The invention for the first time provides strong evidence of a susceptibility gene for bipolar mood disorder that is located in the terminal 5 cM region of the short arm of chromosome 18. The disclosure describes the use of linkage analysis and genetic markers in this 5 cM region to fine map the region and the use of genetic markers to genetically diagnose (genotype) bipolar mood disorder in individuals, to confirm phenotypic diagnoses of bipolar mood disorder, to determine appropriate treatments for patients with particular genotypic subtypes.
    Type: Grant
    Filed: November 24, 1997
    Date of Patent: June 15, 2004
    Assignees: The Regents of the University of California, Univerisity of Costa Rica
    Inventors: Nelson B. Freimer, Lodewijk Sandkuijl, Pedro Leon, Victor I. Reus, Michael Escamilla, Lynne Allison McInnes, Susan K. Service
  • Methods for treating bipolar mood disorder associated with markers on chromosome 18q
    Patent number: 6136532
    Abstract: The present invention is directed to methods of detecting the presence of a bipolar mood disorder susceptibility locus in an individual, comprising analyzing a sample of DNA for the presence of a DNA polymorphism on the long arm of chromosome 18 between markers D18S469 and D18S554, wherein the DNA polymorphism is associated with a form of bipolar mood disorder. The invention for the first time provides strong evidence of a susceptibility gene for bipolar mood disorder that is located in the 18q22-q23 region of the long arm of chromosome 18. The disclosure describes the use of linkage analysis and genetic markers in this 18q22-q23 region to fine map the region and the use of genetic markers to genetically diagnose (genotype) bipolar mood disorder in individuals, to confirm phenotypic diagnoses of bipolar mood disorder, to determine appropriate treatments for patients with particular genotypic subtypes.
    Type: Grant
    Filed: November 24, 1997
    Date of Patent: October 24, 2000
    Assignees: The Regents of the University of California, The University of Costa Rica
    Inventors: Nelson B. Freimer, Lodewijk Sandkuijl, Pedro Leon, Victor I. Reus, Michael Escamilla, Lynne Allison McInnes