Patents by Inventor Victor J. Lotti

Victor J. Lotti has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Pharmaceutical treatment methods using angiotensin II receptor agonists bearing a thiophene moiety
    Patent number: 5444067
    Abstract: This invention relates to compounds represented by formula I: ##STR1## which are agonists of angiotensin II. The invention is also concerned with the use of aforementioned agonists in the treatment of states meditated by angiotensin.
    Type: Grant
    Filed: August 30, 1993
    Date of Patent: August 22, 1995
    Assignee: Merck & Co., Inc.
    Inventors: Salah Kivlighn, Victor J. Lotti, Ralph A. Rivero, Peter K. S. Siegl, Gloria J. Zingaro
  • Substituted pyrazine and its salts, compositions containing them and their use in medicine
    Patent number: 5384408
    Abstract: 3(R)-[2-(6-trifluoromethylpyrazin)yl]-1-azabicyclo[2.2.2]octane and its salts, and pharmaceutical formulations thereof are useful in medicine. In particular, they are useful for the treatment of neurological and mental illnesses whose clinical manifestations are due to cholinergic deficiency, and for lowering intraocular pressure. The compound may be prepared by dehydroxylating or decarboxylating the corresponding 3-hydroxy- or carboxy-quinuclidine analogue.
    Type: Grant
    Filed: March 10, 1993
    Date of Patent: January 24, 1995
    Assignee: Merck Sharpe & Dohme Ltd.
    Inventors: Raymond Baker, Victor J. Lotti, Graham A. Showell
  • Pyrroloquinoline Bradykinin antagonist
    Patent number: 5288725
    Abstract: A pyrroloquinoline compound of the following formula is disclosed: ##STR1## wherein H,C.sub.1-6 alkyl,R.sup.1 is: ##STR2## wherein R is H, C.sub.1-10 alkyl, or C.sub.1-6 alkyloxycarbonyl; R.sup.2 is:H,C.sub.1-6 alkyl, ##STR3## wherein R.sup.5 is C.sub.1-10 alkyl, aryl, or aryl C.sub.1-10 alkyl; R.sup.3 is:(CH.sub.2).sub.n NHR wherein R is H, C.sub.1-6 alkyl, or C.sub.1-6 alkyloxycarbonyl; ##STR4## R.sup.4 is: H,C.sub.1-6 alkyl,C.sub.1-6 alkyloxycarbonyl,RCH.sub.2 --, wherein R is H, C.sub.1-6 alkyl or aryl, or ##STR5## X is O, or NR.sup.6 wherein R.sup.6 is equal to H or C.sub.1-6 alkyl and n is an integer from 1-3.The compounds of the invention exhibit bradykinin antagonist activity as well as activity with .alpha.-adrenergic, histaminergic, and muscarinic receptors.
    Type: Grant
    Filed: October 15, 1992
    Date of Patent: February 22, 1994
    Assignee: Merck & Co., Inc.
    Inventors: Keith M. Witherup, Richard W. Ransom, Sandor L. Varga, Steven M. Pitzenberger, Victor J. Lotti, William J. Lumma
  • Method to reduce introacular pressure without causing miosis
    Patent number: 5153205
    Abstract: Topical administration of a cholinomimetic agent, such as pilocarpine, in combination with a cholinergic M.sub.3 receptor antagonist, such as 4-diphenyl-acetoxy-N-methylpiperidine, to the eye of a mammal reduces intraocular pressure without the concommitant miotic effect that normally occurs with administration of a cholinomimetic agent along.
    Type: Grant
    Filed: October 1, 1990
    Date of Patent: October 6, 1992
    Assignee: Merck & Co., Inc.
    Inventor: Victor J. Lotti
  • Method of treating hypertension
    Patent number: 4215110
    Abstract: A method of treating hypertension by administration, to hypertensive patients, of an anti-hypertensive amount of certain tripeptides, is disclosed.
    Type: Grant
    Filed: September 22, 1978
    Date of Patent: July 29, 1980
    Assignee: Merck & Co., Inc.
    Inventors: Victor J. Lotti, Clement A. Stone