Abstract: A multi-focal, multi-camera endoscope having a tip section including a first optical assembly for generating a first image of a body cavity; a second optical assembly for generating a second image of a body cavity; at least one illuminator associated with each of the first optical assembly and second optical assembly; and a processing system configured to: zoom the first optical assembly and thereby generate a zoomed first image in place of the first image; and automatically cause a physical display to eliminate a display of the second image and to only display said zoomed first image. To eliminate the display of the second image, the processing system reduces a power supply to the second optical assembly, reduces an illumination intensity of an illuminator associated with the second optical assembly or causes the physical display to power off, darken, or blacken.

Abstract: A multi-focal, multi-camera endoscope having a tip section including a first optical assembly for generating a first image of a body cavity; a second optical assembly for generating a second image of a body cavity; at least one illuminator associated with each of the first optical assembly and second optical assembly; and a processing system configured to: zoom the first optical assembly and thereby generate a zoomed first image in place of the first image; and automatically cause a physical display to eliminate a display of the second image and to only display said zoomed first image. To eliminate the display of the second image, the processing system reduces a power supply to the second optical assembly, reduces an illumination intensity of an illuminator associated with the second optical assembly or causes the physical display to power off, darken, or blacken.

Abstract: Eflornithine is an agent that can be used to treat glioma, especially glioma of WHO Grade II or Grade III such as anaplastic glioma. Eflornithine can suppress or prevent mutations in glioma which can cause the glioma to progress to a higher grade. The present invention describes pharmaceutical compositions that contain eflornithine or a derivative, analog, or prodrug thereof. The pharmaceutical compositions can be prepared in a number of dosage forms and may contain another therapeutically active agent or an agent that enhances the therapeutic activity of the eflornithine or the derivative, analog, or prodrug thereof. The present invention also describes a kit that includes dosage forms of pharmaceutical compositions according to the present invention.

Abstract: There is provided herein an optical system for a tip section of a multi-sensor endoscope, the system comprising: a front-pointing camera sensor; a front objective lens system; a side-pointing camera sensor; and a side objective lens system, wherein at least one of said front and side objective lens systems comprises a front and a rear sub-systems separated by a stop diaphragm, said front sub-system comprises, in order from the object side, a first front negative lens and a second front positive lens, said rear sub-system comprises, in order from the object side, a first rear positive lens, an achromatic sub-assembly comprising a second rear positive lens and a third rear negative lens, wherein the following condition is satisfied: f(first rear positive lens)?1.8f, where f is the composite focal length of the total lens system and f(first rear positive lens) is the focal length of said first rear positive lens.

Abstract: The present specification is directed towards endoscopes, such as colonoscopes, that provide a broader field of view and allow extended access of surgical tools and also enable efficient packing of all necessary elements in the tip section, while maintaining their functionality. Also described are methods and systems for capturing and displaying still and video images using an endoscope corresponding to a left-side looking, a front-looking and a right-side looking viewing element of an endoscopic tip generated in a native aspect ratio.

Abstract: Provided is an endoscope having a tip at a distal section thereof, the tip includes a plurality of imaging units, at least one of the imaging units includes at least two optical lens assemblies and at least one optical sensor associated with the at least two optical lens assemblies, wherein each optical lens assembly has a different depth of field, thereby allowing to obtain a multi-focal image of a body cavity. Further provided are systems comprising the endoscope and methods of using the same in various endoscopic procedures.

Abstract: There is provided herein, an electronic circuit board assembly for a tip section of a multiple viewing elements endoscope, the assembly including a base board configured to carry a first metal frame to support a front looking viewing element and a second metal frame to support a side looking viewing element; and a flexible illumination circuit board comprising a front foldable panel configured to carry three sets of front illuminators for essentially illuminating the field of view (FOV) of the front looking viewing element, and a side foldable panel configured to carry a set of side illuminators for essentially illuminating the field of view (FOV) of the side looking viewing element.

Abstract: Endoscopes of this disclosure, such as colonoscopes, provide a broader field of view and allow extended access of surgical tools, and also enable efficient packing of all necessary elements in the tip section, while maintaining their functionality. Methods and systems of this disclosure include for capturing and displaying still and video images using an endoscope corresponding to a left-side looking viewing element, a front-looking viewing element, and a right-side looking viewing element of an endoscopic tip generated in a native aspect ratio.

Abstract: There is provided herein an optical system for a tip section of a multi-sensor endoscope, the system comprising: a front-pointing camera sensor; a front objective lens system; a side-pointing camera sensor; and a side objective lens system, wherein at least one of said front and side objective lens systems comprises a front and a rear sub-systems separated by a stop diaphragm, said front sub-system comprises, in order from the object side, a first front negative lens and a second front positive lens, said rear sub-system comprises, in order from the object side, a first rear positive lens, an achromatic sub-assembly comprising a second rear positive lens and a third rear negative lens, wherein the following condition is satisfied: f(first rear positive lens)?1.8f, where f is the composite focal length of the total lens system and f(first rear positive lens) is the focal length of said first rear positive lens.

Abstract: Ultrasound (US) simulation systems and methods are provided, which utilize computer tomography (CT) data to generate US simulation images, offline or online. Systems and methods repeatedly derive and display consecutive US simulation images that correspond to consecutively-derived corresponding US slices (according to the changing locations and orientations of a dummy US transducer mimicking the US transducer with respect to a physical patient model)—that define geometrically US simulation regions. The US simulation images are at least partly derived from CT data using a CT to US conversion model. Acoustic parameters (e.g., tissue density, acoustic attenuation and impedance) are calculated and integrated per pixel, along beams in the US slice, to form the US image. Additional modelling may be used to calculate reflection and scattering and their effects on the image pixels, and enhancements such as animation and flow data may be added.

Abstract: The present subject matter provides a system for allowing controlled access of a tool to all sides of an elevated tissue in body of a patient, the system including: a rail configured to surround the elevated tissue; and at least one vehicle configured to move along the rail and carry at least one tool configured to manipulate the elevated tissue. Also provided is a method for cutting an elevated tissue in a body of a patient, the method including: inserting a rail to a vicinity of the elevated tissue; surrounding the elevated tissue with the rail; placing a vehicle on the rail; connecting a cutting device to the vehicle; and moving the vehicle along the rail while cutting the elevated tissue with the cutting device. Additional embodiments of the system and method are disclosed herein.

Abstract: There is provided herein, an electronic circuit board assembly for a tip section of a multiple viewing elements endoscope, the assembly including a base board configured to carry a first metal frame to support a front looking viewing element and a second metal frame to support a side looking viewing element; and a flexible illumination circuit board comprising a front foldable panel configured to carry three sets of front illuminators for essentially illuminating the field of view (FOV) of the front looking viewing element, and a side foldable panel configured to carry a set of side illuminators for essentially illuminating the field of view (FOV) of the side looking viewing element.

Abstract: Eflornithine is an agent that can be used to treat glioma, especially glioma of WHO Grade II or Grade III such as anaplastic glioma. Eflornithine can suppress or prevent mutations in glioma which can cause the glioma to progress to a higher grade. The present invention describes pharmaceutical compositions that contain eflornithine or a derivative, analog, or prodrug thereof. The pharmaceutical compositions can be prepared in a number of dosage forms and may contain another therapeutically active agent or an agent that enhances the therapeutic activity of the elformithine or the derivative, analog, or prodrug thereof. The present invention also describes a kit that includes dosage forms of pharmaceutical compositions according to the present invention.

Abstract: A multi-focal, multi-camera endoscope having a tip section including a first optical assembly for generating a first image of a body cavity; a second optical assembly for generating a second image of a body cavity; at least one illuminator associated with each of the first optical assembly and second optical assembly; and a processing system configured to: zoom the first optical assembly and thereby generate a zoomed first image in place of the first image; and automatically cause a physical display to eliminate a display of the second image and to only display said zoomed first image. To eliminate the display of the second image, the processing system reduces a power supply to the second optical assembly, reduces an illumination intensity of an illuminator associated with the second optical assembly or causes the physical display to power off, darken, or blacken.

Abstract: The subject matter disclosed in the present invention discloses a medical imaging device comprising at least two cameras. The medical imaging device comprises an elongated and narrow distal tip connected to a rigid elongated shaft member, wherein the distal tip can comprise a front camera and a first side camera. The cameras of the disclosed medical imaging device can be configured to provide variable cameras' magnifications, which in some cases may vary from one camera to another. The distal tip can comprise some optical gear required for the medical procedures. The optical gear located in the distal tip can comprise cameras, lenses and light sources required for the camera functioning. The cameras of the medical imaging device may be provided with dissimilarity in the cameras' magnification factors. Such dissimilarities are used to show the same object in the same size in a panoramic image captured simultaneously by multiple cameras, as the multiple cameras have multiple distances to the object.

Abstract: Ultrasound (US) simulation systems and methods are provided, which utilize computer tomography (CT) data to generate US simulation images, offline or online. Systems and methods repeatedly derive and display consecutive US simulation images that correspond to consecutively-derived corresponding US slices (according to the changing locations and orientations of a dummy US transducer mimicking the US transducer with respect to a physical patient model)—that define geometrically US simulation regions. The US simulation images are at least partly derived from CT data using a CT to US conversion model. Acoustic parameters (e.g., tissue density, acoustic attenuation and impedance) are calculated and integrated per pixel, along beams in the US slice, to form the US image. Additional modelling may be used to calculate reflection and scattering and their effects on the image pixels, and enhancements such as animation and flow data may be added.

Abstract: A multi-focal, multi-camera endoscope having a tip section including a first optical assembly for generating a first image of a body cavity; a second optical assembly for generating a second image of a body cavity; at least one illuminator associated with each of the first optical assembly and second optical assembly; and a processing system configured to: zoom the first optical assembly and thereby generate a zoomed first image in place of the first image; and automatically cause a physical display to eliminate a display of the second image and to only display said zoomed first image. To eliminate the display of the second image, the processing system reduces a power supply to the second optical assembly, reduces an illumination intensity of an illuminator associated with the second optical assembly or causes the physical display to power off, darken, or blacken.

Abstract: A medical imaging device including at least two cameras. The medical imaging device includes an elongated and narrow distal tip connected to a rigid elongated shaft member, wherein the distal tip includes a front camera and a first side camera. The cameras of the disclosed medical imaging device can be configured to provide variable cameras' magnifications, which in some cases may vary from one camera to another. The cameras of the medical imaging device may be provided with dissimilarity in the cameras' magnification factors. Such dissimilarities are used to show the same object in the same size in a panoramic image captured simultaneously by the multiple cameras, as the multiple cameras have multiple distances to the object.

Abstract: The present specification is directed towards endoscopes, such as colonoscopes, that provide a broader field of view and allow extended access of surgical tools and also enable efficient packing of all necessary elements in the tip section, while maintaining their functionality. Also described are methods and systems for capturing and displaying still and video images using an endoscope corresponding to a left-side looking, a front-looking and a right-side looking viewing element of an endoscopic tip generated in a native aspect ratio.

Abstract: The subject matter disclosed in the present invention discloses a medical imaging device comprising at least two cameras. The medical imaging device comprises an elongated and narrow distal tip connected to a rigid elongated shaft member, wherein the distal tip can comprise a front camera and a first side camera. The cameras of the disclosed medical imaging device can be configured to provide variable cameras' magnifications, which in some cases may vary from one camera to another. The distal tip can comprise some optical gear required for the medical procedures. The optical gear located in the distal tip can comprise cameras, lenses and light sources required for the camera functioning. The cameras of the medical imaging device may be provided with dissimilarity in the cameras' magnification factors. Such dissimilarities are used to show the same object in the same size in a panoramic image captured simultaneously by multiple cameras, as the multiple cameras have multiple distances to the object.