Abstract: The invention in one aspect relates to recombinant replication competent adenovirus that can replicate in and lyse a host cell comprising in the genome of the adenovirus a coding sequence for a glycogen synthase kinase-3 (GSK3) protein operably linked to an expression control sequence. It also relates, among others, to means and methods for treatment of cancer with a coding sequence for a glycogen synthase kinase-3 (GSK3) protein operably linked to an expression control sequence, preferably in the context of an adenovirus. This work was funded in part by European Union Horizon 2020 research and innovation programme, Marie-Sklodowska-Curie grant number 643130.

Abstract: Provided herein are KRAS G12C inhibitors, composition of the same, and methods of using the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.

Abstract: The present disclosure provides methods for generating insect strains that can be used for genetic suppression or modification of insect populations. The method of the present disclosure covers both gene drive (GD) approaches and genetic sterile insect technique (gSIT, aka pgSIT), and uses an RNA-guided nuclease, such as Cpf1 (aka Cas12a), which has a temperature-dependent activity and turns genetic approaches for insect control to temperature-controllable systems.

Abstract: The present disclosure provides the ability of low-cutting gRNAs to circumvent the maternal effect by delaying their action in time. Low-cutting gRNAs lead to a compounding dynamic drive efficiency, which results in drive efficiencies comparable to that of high-cutting gRNAs. Additionally, a gene drive system with a low-cutting gRNA outperforms a more efficient gRNA in laboratory caged populations.

Abstract: Systems are disclosed relating to a mobile device mounted to a welding helmet such that a wearer of the welding helmet can see a display of the mobile device when wearing the welding helmet. In some examples, the mobile device is mounted such that a camera of the mobile device is unobscured and positioned at approximately eye level, facing the same way the wearer's eyes are facing. In some examples, the simulated training environment may be presented to the user via the display screen of the mobile device, using images captured by the camera of the mobile device, when the mobile device is so mounted to the welding helmet.

Abstract: The disclosure is generally directed to in-vehicle entertainment systems and methods. An example method executed by processor of a vehicle may include displaying an iconic representation containing a first icon representing a musical instrument and a second icon representing a vehicle component. The processor may detect an assigning of the musical instrument to the vehicle component. The assigning may be carried out, for example, by a driver of the vehicle executing a drag-and-operation to overlap the first icon with second icon. The processor may then detect a physical contact made upon the vehicle component and generate, based on detecting the physical contact, a musical sound corresponding to the musical instrument.

Abstract: Systems are disclosed relating to a mobile device mounted to a welding helmet such that a wearer of the welding helmet can see a display of the mobile device when wearing the welding helmet. In some examples, the mobile device is mounted such that a camera of the mobile device is unobscured and positioned at approximately eye level, facing the same way the wearer's eyes are facing. In some examples, the simulated training environment may be presented to the user via the display screen of the mobile device, using images captured by the camera of the mobile device, when the mobile device is so mounted to the welding helmet.

Abstract: Systems are disclosed relating to a weld module for weld training systems. In some examples, a weld module is configured for attachment to (and/or detachment from) a plug of a welding tool (e.g., welding torch, gun, stinger, foot pedal, etc.). The weld module may be configured to detect tool events based one or more signals received from the plug of the welding tool. The weld module may communicate the tool events to the weld training system for use during a weld simulation, for example.

Abstract: According to certain aspects of the present disclosure, a device is provided. The device includes a thin film of cobalt. A platinum layer is disposed on the thin film of cobalt. An aluminum layer is disposed on the platinum layer. The aluminum layer disposed on the platinum layer encapsulates the thin film of cobalt. A plurality of electrical contacts is in electrical communication with the thin film of cobalt. Two electrical contacts of the plurality of electrical contacts are configured to receive a write-current therebetween. Four electrical contacts of the plurality of contacts are configured for reading a 4-point resistance.

Abstract: Systems are disclosed relating to a weld module for weld training systems. In some examples, a weld module is configured for attachment to (and/or detachment from) a plug of a welding tool (e.g., welding torch, gun, stinger, foot pedal, etc.). The weld module may be configured to detect tool events based one or more signals received from the plug of the welding tool. The weld module may communicate the tool events to the weld training system for use during a weld simulation, for example.

Abstract: The disclosure is generally directed to in-vehicle entertainment systems and methods. An example method executed by processor of a vehicle may include displaying an iconic representation containing a first icon representing a musical instrument and a second icon representing a vehicle component. The processor may detect an assigning of the musical instrument to the vehicle component. The assigning may be carried out, for example, by a driver of the vehicle executing a drag-and-operation to overlap the first icon with second icon. The processor may then detect a physical contact made upon the vehicle component and generate, based on detecting the physical contact, a musical sound corresponding to the musical instrument.

Abstract: Systems for simulating joining operations, such as welding, are disclosed. In some examples, a system may use a mobile device for conducting welding simulations, such as for purposes of training. In some examples, the system may additionally, or alternatively, use modular workpieces. In some examples, the system may additionally, or alternatively, conduct the welding simulation based on one or more selected pieces of welding equipment.

Abstract: Systems for simulating joining operations, such as welding, are disclosed. In some examples, a system may use a desktop device for conducting welding simulations, such as for purposes of training. In some examples, the system may additionally, or alternatively, use modular workpieces. In some examples, the system may additionally, or alternatively, conduct the welding simulation based on one or more selected pieces of welding equipment.

Abstract: Systems are disclosed relating to a mobile device mounted to a welding helmet such that a wearer of the welding helmet can see a display of the mobile device when wearing the welding helmet. In some examples, the mobile device is mounted such that a camera of the mobile device is unobscured and positioned at approximately eye level, facing the same way the wearer's eyes are facing. In some examples, the simulated training environment may be presented to the user via the display screen of the mobile device, using images captured by the camera of the mobile device, when the mobile device is so mounted to the welding helmet.

Abstract: Systems are disclosed relating to a mobile device mounted to a welding helmet such that a wearer of the welding helmet can see a display of the mobile device when wearing the welding helmet. In some examples, the mobile device is mounted such that a camera of the mobile device is unobscured and positioned at approximately eye level, facing the same way the wearer's eyes are facing. In some examples, the simulated training environment may be presented to the user via the display screen of the mobile device, using images captured by the camera of the mobile device, when the mobile device is so mounted to the welding helmet.

Abstract: Systems for simulating joining operations, such as welding, are disclosed. In some examples, a system may use a mobile device for conducting welding simulations, such as for purposes of training. In some examples, the system may additionally, or alternatively, use modular workpieces. In some examples, the system may additionally, or alternatively, conduct the welding simulation based on one or more selected pieces of welding equipment.

Abstract: Systems for simulating joining operations, such as welding, are disclosed. In some examples, a system may use a mobile device for conducting welding simulations, such as for purposes of training. In some examples, the system may additionally, or alternatively, use modular workpieces. In some examples, the system may additionally, or alternatively, conduct the welding simulation based on one or more selected pieces of welding equipment.

Abstract: A system and method for validating proof of transit of network traffic through network nodes (N), the node (N) comprising a set of input interfaces (20) receiving incoming packets, a first module (A) to identify a matching route within a routing table (23) and storing means (22) to provide next modules (B, C, D) with two private keys if the packet is matched and/or the packet metadata includes OPoT information. The second module (B) decrypts the OPoT metadata using the first private key associated to the link of the node from which the incoming packets are received. The node (N) has SSS metadata to be processed by a third module (C) for the correct generation of cumulative validation parameters. When the SSS process is finished by the third module (C), the fourth module (D) re-encrypts the OPoT metadata using the second private key before packet forwarding to the subsequent node in the path through output interfaces (21).

Abstract: Systems for simulating joining operations, such as welding, are disclosed. In some examples, a system may use a mobile device for conducting welding simulations, such as for purposes of training. In some examples, the system may additionally, or alternatively, use modular workpieces. In some examples, the system may additionally, or alternatively, conduct the welding simulation based on one or more selected pieces of welding equipment.

Abstract: Systems are disclosed relating to a mobile device mounted to a welding helmet such that a wearer of the welding helmet can see a display of the mobile device when wearing the welding helmet. In some examples, the mobile device is mounted such that a camera of the mobile device is unobscured and positioned at approximately eye level, facing the same way the wearer's eyes are facing. In some examples, the simulated training environment may be presented to the user via the display screen of the mobile device, using images captured by the camera of the mobile device, when the mobile device is so mounted to the welding helmet.