Abstract: The present disclosure relates to novel dosage forms, drug delivery regimens, methods and pharmaceutical compositions which optimize the therapeutic effects of active therapeutic substances through the application of the concept of uneven dosing.

Abstract: The present disclosure relates to novel dosage forms, drug delivery regimens, methods and pharmaceutical compositions which optimize the therapeutic effects of active therapeutic substances through the application of the concept of uneven dosing.

Abstract: The present disclosure relates to novel dosage forms, drug delivery regimens, methods and pharmaceutical compositions which optimize the therapeutic effects of active therapeutic substances through the application of the concept of uneven dosing.

Abstract: Particles are enrobed or coated by introducing, to a spinning cup having an outwardly upwardly extending inner surface with an upper edge, a liquid coating material and particles of greater density than the coating material. The coating material and particles are introduced inboard of the peripheral surface, perferably in separate streams. The speed of rotation of the spinning cup is controlled to cause the coating material to climb up the surface but to stop short of the upper edge, and at the same time to cause the particles to travel through the coating material, be enrobed with the coating liquid, climb out of the liquid coating material, and be ejected over the upper edge. The spinning cup is symmetrical about a central vertical axis. It has a peripheral surface sloping outwardly upwardly, which surface can be stepped outwardly upwardly, and a control device is provided for controlling the speed of rotation of the spinning cup.

Abstract: An exercise machine in which four interconnected movable stations are provided, two hand and two foot, one hand and one foot station being connected by a cable by way of pulleys for moving the stations in opposite directions in response to the exertion by the user of a preponderant force upon one of the stations, the other hand and foot station being connected by another cable by way of pulleys for moving the stations in opposite directions in response to the exertion by the user of a preponderant force upon one of the stations, and the two foot stations being connected to one another for moving the foot stations in opposite directions in response to the exertion by the user of a preponderant force upon one of the foot stations. A method of exercise is provided that includes pitting all four members, both arms and both legs, against one another to cause all four members to move separately but simultaneously, the members moving in response to the exertion of a preponderant force by a member or members.

Abstract: An exercise machine in which four interconnected movable stations are provided, two hand and two foot, one hand and one foot station being connected by a cable by way of pulleys for moving the stations in opposite directions in response to the exertion by the user of a preponderant force upon one of the stations, the other hand and foot station being connected by another cable by way of pulleys for moving the stations in opposite directions in response to the exertion by the user of a preponderant force upon one of the stations, and the two foot stations being connected to one another for moving the foot stations in opposite directions in response to the exertion by the user of a preponderant force upon one of the foot stations.