Abstract: The disclosure provides orally administrable capsules comprising abuse-resistant, pharmaceutical formulations which comprise abuse-susceptible active agents such as opioids. The formulations provide abuse resistance by having a sufficiently high viscosity that substantially prevents the formulation and opioid therein, from being drawn into a syringe, at room temperature or higher, either alone or when mixed with water or other liquids.

Abstract: Hard shell capsules filled with a pharmaceutical medicament and at least one modifier, selected to prevent abuse of the medicament are described. The modifier may have a high melting point, and therefore melt at a temperature too high to inject or be insoluble in liquid, having a density less than 1, to prevent “spiking” of drinks. The modifier may also be a waxy substance which cannot be crushed, a viscosity modifier, a dye or a taste modifier.

Abstract: Hard shell capsules filled with a normally hygroscopic formulation and a method for producing the same is described. The hard shell capsules are filled with a normally hygroscopic formulation including, for example, an excipient, and optionally an active compound. The water content of the formulation and the hard shell capsule are in equilibration, and the formulation is hydrated by an amount selected to control equilibrium between said formulation and the hard shell capsule, and to provide a structurally stable hard shell capsule. The active compound may be a protein or peptide.

Abstract: Hard shell capsules filled with a pharmaceutical medicament and at least one modifier, selected to prevent abuse of the medicament are described. The modifier may have a high melting point, and therefore melt at a temperature too high to inject or be insoluble in liquid, having a density less than 1, to prevent “spiking” of drinks. The modifier may also be a waxy substance which cannot be crushed, a viscosity modifier, a dye or a taste modifier.

Abstract: Capsules are filled with liquid-fill by introducing the liquid into a capsule body held in an upright orientation. A capsule cap is fitted over an open end of the capsule body to close the capsule. The closed capsule is held in the upright orientation until the contents have stabilised. The holding period allows excess pneumatic pressure to be dissipated prior to sealing the cap to the body. The holding period may alternatively allow solidification of the liquid-fill. Advantageously, the closed capsules are held in an upright tube (4,6) in a vertical stack.

Abstract: Capsules are filled with liquid-fill by introducing the liquid into a capsule body held in an upright orientation. A capsule cap is fitted over an open end of the capsule body to close the capsule. The closed capsule is held in the upright orientation until the contents have stabilised. The holding period allows excess pneumatic pressure to be dissipated prior to sealing the cap to the body. The holding period may alternatively allow solidification of the liquid-fill. Advantageously, the closed capsules are held in an upright tube (4,6) in a vertical stack.

Abstract: A sealant solution for sealing capsules comprises a mixture of HPMC and a solute which elevates the thermal gelation temperature of the HPMC, and also a mixture of a gelling agent and a hydrolysing agent, wherein said hydrolysing agent decreases the solution temperature of said gelling agent. The sealant solution is produced by mixing a first subordinate solution, which contains the HPMC and solute, and a second subordinate solution, which contains the gelling agent and the hydrolysing agent, the first and second subordinate solutions being heated before mixing.