Patents by Inventor Victor Nurcombe

Victor Nurcombe has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Stem cell subpopulations with differential GSTT1 expression or genotype
    Patent number: 11806368
    Abstract: A method for providing a sub-population of stem cell or plurality of stem cells by determining or modulating GSTT1 expression level or genotype is disclosed together with uses of the stem cells.
    Type: Grant
    Filed: May 15, 2020
    Date of Patent: November 7, 2023
    Assignee: Agency for Science, Technology and Research
    Inventors: Lawrence Stanton, Padmapriya Sathiyanathan, Simon Cool, Victor Nurcombe, Rebekah M. Samsonraj
  • Heparin and heparan sulphate oligosaccharides
    Patent number: 11806362
    Abstract: Isolated heparin or heparan sulphate oligosaccharide fragments having a chain length of at least 10 saccharides and no more than 50 saccharides, which are capable of binding BMP2, are disclosed. Also disclosed is the use of the same heparin or heparan sulphate oligosaccharide fragments in kits and pharmaceutical compositions, and the use of the same heparan sulphate oligosaccharide fragments in the repair and/or regeneration of connective tissue and bones, and the treatment of wounds.
    Type: Grant
    Filed: April 25, 2022
    Date of Patent: November 7, 2023
    Assignee: Agency for Science, Technology and Research
    Inventors: Raymond Alexander Alfred Smith, Simon McKenzie Cool, Victor Nurcombe, Sadasivam Murali
  • HEPARIN AND HEPARAN SULPHATE OLIGOSACCHARIDES
    Publication number: 20220347205
    Abstract: Isolated heparin or heparan sulphate oligosaccharide fragments having a chain length of at least 10 saccharides and no more than 50 saccharides, which are capable of binding BMP2, are disclosed. Also disclosed is the use of the same heparin or heparan sulphate oligosaccharide fragments in kits and pharmaceutical compositions, and the use of the same heparan sulphate oligosaccharide fragments in the repair and/or regeneration of connective tissue and bones, and the treatment of wounds.
    Type: Application
    Filed: April 25, 2022
    Publication date: November 3, 2022
    Inventors: Raymond Alexander Alfred Smith, Simon McKenzie Cool, Victor Nurcombe, Sadasivam Murali
  • Heparin and heparan sulphate oligosaccharides
    Patent number: 11331337
    Abstract: Isolated heparin or heparan sulphate oligosaccharide fragments having a chain length of at least 10 saccharides and no more than 50 saccharides, which are capable of binding BMP2, are disclosed. Also disclosed is the use of the same heparin or heparan sulphate oligosaccharide fragments in kits and pharmaceutical compositions, and the use of the same heparan sulphate oligosaccharide fragments in the repair and/or regeneration of connective tissue and bones, and the treatment of wounds.
    Type: Grant
    Filed: December 11, 2018
    Date of Patent: May 17, 2022
    Assignee: Agency for Science, Technology and Research
    Inventors: Raymond Alexander Alfred Smith, Simon McKenzie Cool, Victor Nurcombe, Sadasivam Murali
  • HEPARIN AND HEPARAN SULPHATE OLIGOSACCHARIDES
    Publication number: 20210161945
    Abstract: Isolated heparin or heparan sulphate oligosaccharide fragments having a chain length of at least 10 saccharides and no more than 50 saccharides, which are capable of binding BMP2, are disclosed. Also disclosed is the use of the same heparin or heparan sulphate oligosaccharide fragments in kits and pharmaceutical compositions, and the use of the same heparan sulphate oligosaccharide fragments in the repair and/or regeneration of connective tissue and bones, and the treatment of wounds.
    Type: Application
    Filed: December 11, 2018
    Publication date: June 3, 2021
    Inventors: Raymond Alexander Alfred Smith, Simon McKenzie Cool, Victor Nurcombe
  • STEM CELL SUBPOPULATIONS WITH DIFFERENTIAL GSTT1 EXPRESSION OR GENOTYPE
    Publication number: 20200345782
    Abstract: A method for providing a sub-population of stem cell or plurality of stem cells by determining or modulating GSTT1 expression level or genotype is disclosed together with uses of the stem cells.
    Type: Application
    Filed: May 15, 2020
    Publication date: November 5, 2020
    Inventors: Lawrence Stanton, Padmapriya Sathiyanathan, Simon Cool, Victor Nurcombe, Rebekah M. Samsonraj
  • PDGF-B /PDGF-BB binding variants of heparan sulfates
    Patent number: 10723813
    Abstract: Affinity purification of platelet-derived growth factor-binding heparan sulphate from porcine mucosa (HS6) is disclosed. Also disclosed is the use of HS6 in repair and regeneration of the skin for treating wounds, burns, ulcers and other skin injuries.
    Type: Grant
    Filed: January 8, 2016
    Date of Patent: July 28, 2020
    Assignee: Agency for Science, Technology and Research
    Inventors: Simon Cool, Victor Nurcombe
  • Heparan sulphates
    Patent number: 10596296
    Abstract: A heparan sulphate that binds TGP?1 is disclosed.
    Type: Grant
    Filed: April 30, 2015
    Date of Patent: March 24, 2020
    Assignee: Agency for Science, Technology and Research
    Inventors: Simon Cool, Victor Nurcombe, Jonathan Lee
  • Cosmetic use of heparan sulphate
    Patent number: 10493012
    Abstract: Affinity purification of fibroblast growth factor 2-binding heparan sulphate from porcine mucosa (HS8) is disclosed. Also disclosed is a process for the care of keratinous material(s), comprising the application or administration of HS8, or a composition comprising thereof, to keratinous material(s). The composition may be used to improve the condition of skin, such as smoothing the skin, restoring skin elasticity and firmness, or decreasing or preventing wrinkles, and may be formulated for topical or transdermal administration.
    Type: Grant
    Filed: November 19, 2015
    Date of Patent: December 3, 2019
    Assignees: Agency for Science, Technology and Research, L'Oreal
    Inventors: Simon Cool, Victor Nurcombe, Charbel Bouez, Diah Saraswati Bramono
  • Heparan sulphates for use in repair and/or regeneration of skin
    Patent number: 10471091
    Abstract: Affinity purification of fibroblast growth factor 2-binding heparan sulphate from porcine mucosa (HS8) is disclosed. Also disclosed is the use of HS8 in repair and regeneration of the skin for treating wounds, burns, ulcers and other skin injuries.
    Type: Grant
    Filed: November 19, 2015
    Date of Patent: November 12, 2019
    Assignee: Agency for Science, Technology and Research
    Inventors: Simon Cool, Victor Nurcombe
  • HEPARAN SULPHATE
    Publication number: 20190135949
    Abstract: A heparan sulphate that binds vitronectin is disclosed.
    Type: Application
    Filed: January 15, 2019
    Publication date: May 9, 2019
    Inventors: Simon Cool, Victor Nurcombe
  • Heparan sulphates
    Patent number: 10266612
    Abstract: A novel class of structurally and functionally related isolated Heparan sulphate is disclosed. The novel class of Heparan sulphates has been found to bind FGF2 and enhance the proliferation of stem cells while maintaining their pluripotency/multipotency.
    Type: Grant
    Filed: May 16, 2013
    Date of Patent: April 23, 2019
    Assignee: Agency for Science, Technology and Research
    Inventors: Victor Nurcombe, Simon Cool
  • Glycosaminoglycans
    Patent number: 10245281
    Abstract: Heparan sulphate HS7 is disclosed, together with the use of HS7 in the growth and/or development and/or regeneration of tissue.
    Type: Grant
    Filed: July 31, 2015
    Date of Patent: April 2, 2019
    Assignee: Agency for Science, Technology and Research
    Inventors: Simon Cool, Victor Nurcombe
  • Glycosaminoglycans
    Patent number: 10245301
    Abstract: Heparan sulphate HS/BMP2 is disclosed, together with the use of HS/BMP2 in the repair and regeneration of bone tissue.
    Type: Grant
    Filed: September 12, 2016
    Date of Patent: April 2, 2019
    Assignee: Agency for Science, Technology and Research
    Inventors: Simon McKenzie Cool, Victor Nurcombe, Christian Dombrowski
  • Glycosaminoglycans
    Patent number: 10220054
    Abstract: Heparan sulphate HS/BMP2 is disclosed, together with the use of HS/BMP2 in the repair and regeneration of bone tissue.
    Type: Grant
    Filed: October 27, 2016
    Date of Patent: March 5, 2019
    Assignee: Agency for Science, Technology and Research
    Inventors: Simon McKenzie Cool, Victor Nurcombe, Christian Dombrowski
  • Isolation and Identification of Glycosaminoglycans
    Publication number: 20180360916
    Abstract: The isolation and identification of glycosaminoglycans capable of binding to proteins having a heparin-binding domain is disclosed, as well as the use of the glycosaminoglycans isolated in the growth and/or development of tissue.
    Type: Application
    Filed: June 27, 2018
    Publication date: December 20, 2018
    Inventors: Simon McKenzie Cool, Victor Nurcombe, Christian Dombrowski
  • Heparan sulphate which binds BMP2
    Patent number: 10086044
    Abstract: The invention relates to heparan sulphate GAGs obtained by affinity chromatography using the heparin-binding domain of BMP2. The GAGs were obtained from osteoblast extracellular matrix and from a commercially available heparan sulfate (Celsus HS).
    Type: Grant
    Filed: September 11, 2009
    Date of Patent: October 2, 2018
    Assignee: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
    Inventors: Simon McKenzie Cool, Victor Nurcombe, Christian Dombrowski
  • PDGF-B /PDGF-BB BINDING VARIANTS OF HEPARAN SULFATES
    Publication number: 20180258193
    Abstract: Affinity purification of platelet-derived growth factor-binding heparan sulphate from porcine mucosa (HS6) is disclosed. Also disclosed is the use of HS6 in repair and regeneration of the skin for treating wounds, burns, ulcers and other skin injuries.
    Type: Application
    Filed: January 8, 2016
    Publication date: September 13, 2018
    Inventors: Simon Cool, Victor Nurcombe
  • COSMETIC USE OF HEPARAN SULPHATE
    Publication number: 20170326059
    Abstract: Affinity purification of fibroblast growth factor 2-binding heparan sulphate from porcine mucosa (HS8) is disclosed. Also disclosed is a process for the care of keratinous material(s), comprising the application or administration of HS8, or a composition comprising thereof, to keratinous material(s). The composition may be used to improve the condition of skin, such as smoothing the skin, restoring skin elasticity and firmness, or decreasing or preventing wrinkles, and may be formulated for topical or transdermal administration.
    Type: Application
    Filed: November 19, 2015
    Publication date: November 16, 2017
    Inventors: Simon Cool, Victor Nurcombe, Charbel Bouez, Diah Saraswati Bramono
  • HEPARAN SULPHATES FOR USE IN REPAIR AND/OR REGENERATION OF SKIN
    Publication number: 20170319615
    Abstract: Affinity purification of fibroblast growth factor 2-binding heparan sulphate from porcine mucosa (HS8) is disclosed. Also disclosed is the use of HS8 in repair and regeneration of the skin for treating wounds, burns, ulcers and other skin injuries.
    Type: Application
    Filed: November 19, 2015
    Publication date: November 9, 2017
    Inventors: Simon Cool, Victor Nurcombe