Abstract: A multi-spot ophthalmic laser device that produces spatially distributed laser spots with the spatial distribution of the laser spots defined by a spot diameter to space ratio in the range 1:2 to 1:20. The multi-spot ophthalmic laser device comprises: a laser module producing a laser pulse or sequence of laser pulses each having: a pulse duration in the range of 10 ps to 20 ?s; a wavelength in the range 500 nm to 900 nm; and a pulse energy in the range 10 ?J to 10 mJ per pulse; and an optical beam profiling module that modifies an output beam profile of each pulse of the laser module to deliver multiple spatially distributed laser spots of defined size and energy. The multi-spot ophthalmic laser device is used in a method of improving the function of the retina of a human eye by irradiation through the cornea of the eye to the retinal pigmented epithelium by a treatment laser having a beam profile with spatially distributed energy peaks.

Abstract: A microsurgical instrument includes a cannula head rotationally coupled to a handpiece. A cannula head connector at a distal end of the handpiece rotationally couples to a handpiece connector at a proximal end of the cannula head. The cannula head connector and handpiece connector rotate coaxially about a longitudinal center axis passing through a cannula extending from the cannula head, providing an adjustable cannula angle between the cannula head and handpiece. The cannula head is securely retained to the handpiece without slippage changing the cannula angle, and the cannula angle is easily changed to a new value by deliberate rotation of the cannula head.

Abstract: A microsurgical instrument includes a cannula with a straight segment at a proximal end and a parting tip at a distal end. The parting tip includes a parting tip projection, a convex parting edge formed on the parting tip projection, and a spatulated parting face. The spatulated parting face includes a convex surface portion formed on the parting tip projection and a concave surface portion joined to the convex surface portion along a line of inflection at a proximal end of the parting tip projection. The microsurgical instrument optionally includes a cannula head attached to the cannula. The cannula head includes a tapered outer surface, a circumferential outer flange, an arcuate inner flange, and an inner flange ridge extending radially away from the inner flange. A payload guide attached to the cannula and cannula head directs payloads into the lumen of the cannula.

Abstract: The invention resides in a pattern laser comprising a plurality of laser devices each emitting a treatment laser beam into an optical fibre of an optical fibre bundle. An optical coupling module is associated with each laser device and each optical fibre for coupling a treatment laser beam into the associated optical fibre. A controller controls the operation of the laser devices by selectively turning on or off one or more of the laser devices so as to form a laser treatment pattern at an end of the fibre bundle away from the laser devices. A delivery system images the output from the fibre bundle to a treatment zone.

Abstract: A multi-spot ophthalmic laser device that produces spatially distributed laser spots with the spatial distribution of the laser spots defined by a spot diameter to space ratio in the range 1:2 to 1:20. The multi-spot ophthalmic laser device comprises: a laser module producing a laser pulse or sequence of laser pulses each having: a pulse duration in the range of 10 ps to 20 ?s; a wavelength in the range 500 nm to 900 nm; and a pulse energy in the range 10 ?J to 10 mJ per pulse; and an optical beam profiling module that modifies an output beam profile of each pulse of the laser module to deliver multiple spatially distributed laser spots of defined size and energy. The multi-spot ophthalmic laser device is used in a method of improving the function of the retina of a human eye by irradiation through the cornea of the eye to the retinal pigmented epithelium by a treatment laser having a beam profile with spatially distributed energy peaks.

Abstract: An ophthalmic treatment device for photobiomodulation of a retina comprising: a treatment light source producing a continuous wave or quasi-continuous wave output beam having a wavelength in the range of 600 nm to 1000 nm and a power in the range of 1 mW to 500 mW; a beam homogenizing module that homogenizes the output beam of the treatment light source; a beam shaping module that modifies the output beam profile to produce a treatment light beam with an annular light beam profile; and a beam delivery and viewing module that allows an Operator to observe and operate to deliver the treatment light beam to the treatment location on the retina with an intensity in the range of 1 mW/cm2 to 500 mW/cm2.

Abstract: The invention resides in a pattern laser comprising a plurality of laser devices each emitting a treatment laser beam into an optical fibre of an optical fibre bundle. An optical coupling module is associated with each laser device and each optical fibre for coupling a treatment laser beam into the associated optical fibre. A controller controls the operation of the laser devices by selectively turning on or off one or more of the laser devices so as to form a laser treatment pattern at an end of the fibre bundle away from the laser devices. A delivery system images the output from the fibre bundle to a treatment zone.

Abstract: A method of treating a disease, disorder or condition of the eye includes irradiating the eye or eyes with a laser and subsequently detecting one or more biological responses by the eye or eyes to thereby determine the effectiveness of the laser treatment. The one or more biological responses by the eye or eyes are responses by cells, tissues and/or molecules of the eye or eyes that indicate, are associated with, or are functionally linked to, the effectiveness of the laser treatment. This may include detecting or measuring a change in the expression of one or more genes after laser treatment, such as cytoskeletal genes, matrix metalloproteinase genes, cell cycle genes and extracellular matrix genes. The method may include detecting or measuring cell differentiation, cell death and/or cell proliferation after laser treatment.

Abstract: A laser treatment device for use in retinal regeneration. The laser treatment device includes a laser module that delivers a pulse or sequence of pulses having a pulse duration in the range of 50 ps to 500 ns, a wavelength in the range 500 nm to 900 nm, and a pulse energy in the range 100 ?J to 10 mJ. The laser treatment device also includes a uniform irradiance module that modifies an output beam profile of the laser module to produce a uniform treatment effect and a beam delivery and viewing module that delivers the laser pulse or pulses to the retina with a radiant exposure in the range of 8 mJ/cm2 to 8000 mJ/cm2 per pulse.

Abstract: A laser treatment device for use in retinal regeneration. The laser treatment device includes a laser module that delivers a pulse or sequence of pulses having a pulse duration in the range of 50 ps to 500 ns, a wavelength in the range 500 nm to 900 nm, and a pulse energy in the range 100 ?J to 10 mJ. The laser treatment device also includes a uniform irradiance module that modifies an output beam profile of the laser module to produce a uniform treatment effect and a beam delivery and viewing module that delivers the laser pulse or pulses to the retina with a radiant exposure in the range of 8 mJ/cm2 to 8000 mJ/cm2 per pulse.

Abstract: An ophthalmic laser system (1) for performing procedures such as Retinal Photocoagulation and Laser Trabeculoplasty comprises a delivery module (2) and a console module (3). The console module includes a treatment laser and optical elements for directing output from the treatment laser to an optical fiber (16), which is substantially enclosed within the delivery module. The delivery module includes a slit lamp tower (6), viewing microscope (4) and alignment optics for directing and focusing output from the optical fiber to a patient treatment zone.

Abstract: An ophthalmic laser system (1) for performing procedures such as Retinal Photocoagulation and Laser Trabeculoplasty comprises a delivery module (2) and a console module (3). The console module includes a treatment laser and optical elements for directing output from the treatment laser to an optical fiber (16), which is substantially enclosed within the delivery module. The delivery module includes a slit lamp tower (6), viewing microscope (4) and alignment optics fur directing and focusing output from the optical fiber to a patient treatment zone.