Patents by Inventor Victor R Mokler

Victor R Mokler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compositions and methods for conjugating oligonucleotides
    Patent number: 9512163
    Abstract: An oligonucleotide derivative having the structure of formula (A) and methods for preparing the oligonucleotide derivative are disclosed. wherein R3 is a first oligonucleotide; R1 is selected from the group consisting of alkyl, cycloalkyl, aryl, heterocyclyl, heteroaryl, a polyethylene glycol, a peptide, a protein, a polysaccharide, and a second oligonucleotide; R2 is a linker or a direct bond; Z1 is NR4, S, or O, and Z2 is NR4 or S, wherein R4 is selected from H, alkyl, aryl, heterocyclyl, or heteroaryl. A method includes: synthesizing an oligonucleotide derivative comprising an amino or thiol group; and reacting a 3,4-dialkoxycyclobutene-1,2-dione with the oligonucleotide derivative to produce an oligonucleotide-squarate mono-conjugate.
    Type: Grant
    Filed: April 29, 2013
    Date of Patent: December 6, 2016
    Assignee: Agilent Technologies, Inc.
    Inventors: Kenneth W. Hill, Victor R Mokler
  • Use of N-alkyl imidazole for sulfurization of oligonucleotides with an acetyl disulfide
    Patent number: 9169286
    Abstract: A method and compositions for sulfurizing at least one phosphite or thiophosphite linkage in an oligonucleotide. The addition of N-alkyl imidazole to the acetyldisulfide sulfurization solution enables the use of industrially preferred solvents or solvents that are derived from renewable resources.
    Type: Grant
    Filed: October 9, 2012
    Date of Patent: October 27, 2015
    Assignee: Agilent Technologies, Inc.
    Inventors: Agnieszka B. Sierzchala, Douglas J. Dellinger, Paul A. Metz, Victor R. Mokler
  • Compositions and Methods for Conjugating Oligonucleotides
    Publication number: 20150133631
    Abstract: An oligonucleotide derivative having the structure of formula (A) and methods for preparing the oligonucleotide derivative are disclosed. wherein R3 is a first oligonucleotide; R1 is selected from the group consisting of alkyl, cycloalkyl, aryl, heterocyclyl, heteroaryl, a polyethylene glycol, a peptide, a protein, a polysaccharide, and a second oligonucleotide; R2 is a linker or a direct bond; Z1 is NR4, S, or O, and Z2 is NR4 or S, wherein R4 is selected from H, alkyl, aryl, heterocyclyl, or heteroaryl. A method includes: synthesizing an oligonucleotide derivative comprising an amino or thiol group; and reacting a 3,4-dialkoxycyclobutene-1,2-dione with the oligonucleotide derivative to produce an oligonucleotide-squarate mono-conjugate.
    Type: Application
    Filed: April 29, 2013
    Publication date: May 14, 2015
    Inventors: Kenneth W. Hill, Victor R Mokler
  • Use of thioacetic acid derivatives in the sulfurization of oligonucleotides with phenylacetyl disulfide
    Patent number: 8642755
    Abstract: A method and compositions for sulfurizing at least one phosphite or thiophosphite linkage in an oligonucleotide. The methods employ a phenylacetyl disulfide reagent (known as PADS), phenylthioacetic acid (PTAA) in the presence or absence or N-alkyl imidazole in industrially preferred solvents or solvents that are derived from renewable resources. The use of PTAA eliminates the need to “age” the PADS solution prior to its use in sulfurization reactions.
    Type: Grant
    Filed: June 30, 2009
    Date of Patent: February 4, 2014
    Assignee: Agilent Technologies, Inc.
    Inventors: Agnieszka B. Sierzchala, Douglas J Dellinger, Victor R Mokler, Zoltan Timar
  • Use of N-alkyl imidazole for sulfurization of oligonucleotides with an acetyl disulfide
    Patent number: 8309710
    Abstract: A method and compositions for sulfurizing at least one phosphite or thiophosphite linkage in an oligonucleotide. The addition of N-alkyl imidazole to the acetyldisulfide sulfurization solution enables the use of industrially preferred solvents or solvents that are derived from renewable resources.
    Type: Grant
    Filed: June 29, 2009
    Date of Patent: November 13, 2012
    Assignee: Agilent Technologies, Inc.
    Inventors: Agnieszka B. Sierzchala, Douglas J Dellinger, Paul A. Metz, Victor R Mokler
  • Use Of Thioacetic Acid Derivatives In The Sulfurization Of Oligonucleotides With Phenylacetyl Disulfide
    Publication number: 20100331533
    Abstract: A method and compositions for sulfurizing at least one phosphite or thiophosphite linkage in an oligonucleotide. The methods employ a phenylacetyl disulfide reagent (known as PADS), phenylthioacetic acid (PTAA) in the presence or absence or N-alkyl imidazole in industrially preferred solvents or solvents that are derived from renewable resources. The use of PTAA eliminates the need to “age” the PADS solution prior to its use in sulfurization reactions.
    Type: Application
    Filed: June 30, 2009
    Publication date: December 30, 2010
    Inventors: Agnieszka B. Sierzchala, Douglas J. Dellinger, Victor R. Mokler, Zoltan Timar
  • Use Of N-Alkyl Imidazole For Sulfurization Of Oligonucleotides With An Acetyl Disulfide
    Publication number: 20100331532
    Abstract: A method and compositions for sulfurizing at least one phosphite or thiophosphite linkage in an oligonucleotide. The addition of N-alkyl imidazole to the acetyldisulfide sulfurization solution enables the use of industrially preferred solvents or solvents that are derived from renewable resources.
    Type: Application
    Filed: June 29, 2009
    Publication date: December 30, 2010
    Inventors: Agnieszka B. Sierzchala, Douglas J. Dellinger, Paul A. Metz, Victor R. Mokler