Abstract: System and method for creating enabling the user to select fields from a database, semi structured or unstructured documents that produces an automated process of joining the database tables, semi structured or unstructured documents into a feature vector that can be further processed by machine learning algorithms or preprocessing routines and filters. The full join performed starts by producing a graph representation of the links between data tables/documents and then restructuring the information into the most efficient join tree. The join tree then extracts the data in the form of a feature vector.

Abstract: System and method for creating enabling the user to select fields from a database, semi structured or unstructured documents that produces an automated process of joining the database tables, semi structured or unstructured documents into a feature vector that can be further processed by machine learning algorithms or preprocessing routines and filters. The full join performed starts by producing a graph representation of the links between data tables/documents and then restructuring the information into the most efficient join tree. The join tree then extracts the data in the form of a feature vector.

Abstract: A self-contained system for protecting building penetrations is disclosed. The system can include a housing containing a take-up roll and a screen made from a flexible, strong fabric-like material suitable for resisting high winds, driving rain, and wind-driven missiles. The system can further comprise a deflector or roller to maintain the angle of deployment of the screen. The system can further include a weight bar attached to the end of the screen to assist in deploying the screen. The system can further comprise a dual pulley system to assist in deploying the screen and to hold the screen in the deployed position. The system can include wipers to clean the screen as it is retracted into the enclosure. The system can further comprise an integrated or separate light control, or “black-out” screen. The system enclosures can comprise various hinged covers to facilitate service, repair, and storage.

Abstract: A system for protecting building penetrations is disclosed. The system can include a screen comprising flexible, strong fabric-like material suitable for resisting high winds, driving rain, and wind-driven missiles. The screen can further include loops sewn, or otherwise manufactured, into the span sides of the screen. The system can further include one or more retention channels having an internal hem rod. The loops in the screens can slide over the hem rod to guide and retain the screen in the retention channels. The hem rod can include a tapered end and a loop opener to facilitate the loops sliding over the end of the hem rod. The system can further include an enclosure for housing a take-up roll and a powered or manual rotating system. The system can include a deflection device to enable the screen to unroll off the take-up roll smoothly and vertically.

Abstract: A self-contained system for protecting building penetrations is disclosed. The system can include a housing containing a take-up roll and a screen made from a flexible, strong fabric-like material suitable for resisting high winds, driving rain, and wind-driven missiles. The system can further comprise a deflector or roller to maintain the angle of deployment of the screen. The system can further include a weight bar attached to the end of the screen to assist in deploying the screen. The system can further comprise a dual pulley system to assist in deploying the screen and to hold the screen in the deployed position. The system can include wipers to clean the screen as it is retracted into the enclosure. The system can further comprise an integrated or separate light control, or “black-out” screen. The system enclosures can comprise various hinged covers to facilitate service, repair, and storage.

Abstract: A system for protecting building penetrations is disclosed. The system can include a screen comprising flexible, strong fabric-like material suitable for resisting high winds, driving rain, and wind-driven missiles. The screen can further include loops sewn, or otherwise manufactured, into the span sides of the screen. The system can further include one or more retention channels having an internal hem rod. The loops in the screens can slide over the hem rod to guide and retain the screen in the retention channels. The hem rod can include a tapered end and a loop opener to facilitate the loops sliding over the end of the hem rod. The system can further include an enclosure for housing a take-up roll and a powered or manual rotating system. The system can include a deflection device to enable the screen to unroll off the take-up roll smoothly and vertically.

Abstract: The present invention provides compositions and methods for evaluating the likelihood that a tumor is sensitive to an mTOR inhibitor, e.g., rapamycin or a rapamycin analog. The invention provides FKBP proteins as biomarkers for predicting the likelihood that a tumor is sensitive to an mTOR inhibitor. The methods include assessing the expression or activity of an FKBP protein, e.g., FKBP 12, in a subject with a tumor or in a sample derived from a tumor. Additional biomarkers and biomarker combinations are also provided. The invention also provides kits containing, e.g., a validated antibody or ligand for assessing the expression or activity of an FKBP protein.

Abstract: Single AAV vector constructs for regulated expression of an immunoglobulin molecule or fragment thereof and methods of making and using the same are described. The AAV vectors comprise a regulated promoter operably linked to the coding sequence for a first and second immunoglobulin coding sequence, a sequence encoding a self-processing cleavage site between the coding sequence for the first and second immunoglobulin coding sequence and a additional proteolytic cleavage site, which provides a means to remove the self processing peptide sequence from an expressed immunoglobulin molecule or fragment thereof. The vector constructs find utility in enhanced production of biologically active immunoglobulins or fragments thereof in vitro and in vivo.

Abstract: Materials and methods involving conditional retention domains (CRDs) are disclosed. Also disclosed are fusion proteins containing CRDs and cells expressing such fusion proteins. In addition, the invention provides novel methods for producing target proteins in vivo using fusion proteins containing conditional retention domains and methods for identifying novel CRDs.

Abstract: Materials and methods involving conditional retention domains (CRDs) are disclosed. Also disclosed are fusion proteins containing CRDs and cells expressing such fusion proteins. In addition, the invention provides novel methods for producing target proteins in vivo using fusion proteins containing conditional retention domains and methods for identifying novel CRDs.

Abstract: Methods for high level expression of genes in primates are disclosed. Such methods involve expression of transgenes comprising an RSV promoter and a nucleic acid sequence that is heterologous thereto.