Abstract: Apparatus and methods for providing a single-use, disposable module or manifold for testing and analysis of bioprocesses, as well as a portable and compact device which can be used with the module or manifold. A module comprising a valve, a filter or guard column, an affinity column, and a flow cell is provided with several ports for receiving tubing connections for a sample and one or more solvents, as well as one or more outlet ports for connections to one or more waste reservoirs. The flow cell may use UV light to determine a protein concentration of a sample in one particular example. The module can be connected directly or indirectly to a bioreactor containing the bioprocess and material to be sampled, and can be disposed of once a production run has been completed. In addition, manifolds are provided which can be embodied as a valve assembly, and which can comprise the same components and features as the disposable module. The manifolds and modules are compact and easy to use.

Abstract: Apparatus and methods for providing a single-use, disposable module or manifold for testing and analysis of bioprocesses. A module comprising a valve, a filter or guard column, an affinity column, and a flow cell is provided with several ports for receiving tubing connections for a sample and one or more solvents, as well as one or more outlet ports for connections to one or more waste reservoirs. The flow cell may use UV light to determine a protein concentration of a sample in one particular example. The module can be connected directly or indirectly to a bioreactor containing the bioprocess and material to be sampled, and can be disposed of once a production run has been completed. In addition, manifolds are provided which can be embodied as a valve assembly, and which can comprise the same components and features as the disposable module. The manifolds and modules are compact and easy to use. A portable device for use with a module is also provided.

Abstract: Apparatus and methods for providing a single-use, disposable module or manifold for testing and analysis of bioprocesses. A module comprising a valve, a filter or guard column, an affinity column, and a flow cell is provided with several ports for receiving tubing connections for a sample and one or more solvents, as well as one or more outlet ports for connections to one or more waste reservoirs. The flow cell may use UV light to determine a protein concentration of a sample in one particular example. The module can be connected directly or indirectly to a bioreactor containing the bioprocess and material to be sampled, and can be disposed of once a production run has been completed. In addition, manifolds are provided which can be embodied as a valve assembly, and which can comprise the same components and features as the disposable module. The manifolds and modules are compact and easy to use. A portable device for use with a module is also provided.

Abstract: Apparatus and methods for providing a single-use, disposable module or manifold for testing and analysis of bioprocesses, as well as a portable and compact device which can be used with the module or manifold. A module comprising a valve, a filter or guard column, an affinity column, and a flow cell is provided with several ports for receiving tubing connections for a sample and one or more solvents, as well as one or more outlet ports for connections to one or more waste reservoirs. The flow cell may use UV light to determine a protein concentration of a sample in one particular example. The module can be connected directly or indirectly to a bioreactor containing the bioprocess and material to be sampled, and can be disposed of once a production run has been completed. In addition, manifolds are provided which can be embodied as a valve assembly, and which can comprise the same components and features as the disposable module. The manifolds and modules are compact and easy to use.

Abstract: Devices for detecting an analyte comprising a redox active analyte sensitive material on a working electrode and computer assisted signal acquisition and processing.

Abstract: Devices for detecting an analyte comprising a redox active analyte sensitive material on a working electrode and computer assisted signal acquisition and processing.

Abstract: A pH sensor device for continuously measuring pH in a flowable sample, the device including a housing having a channel and cavity for capturing and directing a sample aliquot to a pH sensor. The pH sensor device may further include a porous material placed adjacent to the pH sensor to attract a sample aliquot to the pH sensor via capillary force.

Abstract: A flexible, surface electromyographic electrode apparatus is provided for use on a surface of biological tissue to measure bio-electric signals thereof. The electrode apparatus includes a conductive signal electrode device having a signal contact adapted to directly contact the surface of the biological tissue, and a signal transmission portion electrically coupled to the signal contact. A conductive ground electrode device of the electrode apparatus includes a ground contact that is adapted directly contact the surface of the biological tissue. A ground transmission portion of the ground electrode device is electrically coupled to the ground contact. The ground contact is disposed substantially about the signal contact so as to substantially surround a peripheral edge of the signal contact when both are in contact with the tissue surface. An insulation washer device is further disposed between the signal contact and the ground contact to substantially prevent conductive contact therebetween.

Abstract: This invention provides an apparatus for preparing chemical libraries. The apparatus includes (1) a carousel comprising a plurality of reaction mounts having at least one reaction well; (2) a rotator that rotates the carousel step-wise; (3) a fluid delivery system; (4) a drain system; and (5) a programmable computer that controls the operation of the apparatus, including the rotator, the fluid delivery system, the drain system and other systems in the apparatus. The preparation-of chemical libraries involves rotating the carousel through a plurality of stations. At each station, a physical step in a reaction protocol is carried out on the reaction wells of the mount docked at the station.

Abstract: This invention provides an apparatus for preparing chemical libraries. The apparatus includes (1) a carousel comprising a plurality of reaction mounts having at least one reaction well; (2) a rotator that rotates the carousel step-wise; (3) a fluid delivery system; (4) a drain system; and (5) a programmable computer that controls the operation of the apparatus, including the rotator, the fluid delivery system, the drain system and other systems in the apparatus. The preparation of chemical libraries involves rotating the carousel through a plurality of stations. At each station, a physical step in a reaction protocol is carried out on the reaction wells of the mount docked at the station.

Abstract: A device for sample collection, sample separation and for aseptically, controllably and precisely transferring at least one of the separated portions is disclosed. The device utilizes a metering syringe to collect a sample, such as blood, the metering syringe with the sample therein is centrifuged, the metering syringe is connected to a sterile syringe contained within sterile packaging, the metering syringe is used to controllably, precisely and aseptically meter a separated portion into the sterile syringe, the sterile syringe with the separated portion therein is then given to appropriate personnel within a sterile field without performing any further transferring steps.