Patents by Inventor Victor W. L. Ng
Victor W. L. Ng has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10786530Abstract: Antimicrobial cationic polymers having one or two cationic polycarbonate chains were prepared by organocatalyzed ring opening polymerization. One antimicrobial cationic polymer has a polymer chain consisting essentially of cationic carbonate repeat units linked to one or two end groups. The end groups can comprise a covalently bound form of biologically active compound such as cholesterol. Other antimicrobial cationic polymers have a random copolycarbonate chain comprising a minor mole fraction of hydrophobic repeat units bearing a covalently bound form of a vitamin E and/or vitamin D2. The cationic polymers exhibit high activity and selectivity against Gram-negative and Gram-positive microbes and fungi.Type: GrantFiled: April 17, 2018Date of Patent: September 29, 2020Assignees: International Business Machines Corporation, Agency For Science, Technology And ResearchInventors: Daniel J. Coady, Richard A. Dipietro, Amanda C. Engler, James L. Hedrick, Ashlynn L. Z. Lee, Victor W. L. Ng, Zhan-Yuin Ong, Yi Yan Yang
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Publication number: 20180228835Abstract: Antimicrobial cationic polymers having one or two cationic polycarbonate chains were prepared by organocatalyzed ring opening polymerization. One antimicrobial cationic polymer has a polymer chain consisting essentially of cationic carbonate repeat units linked to one or two end groups. The end groups can comprise a covalently bound form of biologically active compound such as cholesterol. Other antimicrobial cationic polymers have a random copolycarbonate chain comprising a minor mole fraction of hydrophobic repeat units bearing a covalently bound form of a vitamin E and/or vitamin D2. The cationic polymers exhibit high activity and selectivity against Gram-negative and Gram-positive microbes and fungi.Type: ApplicationFiled: April 17, 2018Publication date: August 16, 2018Inventors: Willy Chin, Daniel J. Coady, Richard A. Dipietro, Amanda C. Engler, James L. Hedrick, Ashlynn L. Z. Lee, Victor W. L. Ng, Zhan-Yuin Ong, Yi Yan Yang
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Patent number: 9999633Abstract: Antimicrobial cationic polymers having one or two cationic polycarbonate chains were prepared by organocatalyzed ring opening polymerization. One antimicrobial cationic polymer has a polymer chain consisting essentially of cationic carbonate repeat units linked to one or two end groups. The end groups can comprise a covalently bound form of biologically active compound such as cholesterol. Other antimicrobial cationic polymers have a random copolycarbonate chain comprising a minor mole fraction of hydrophobic repeat units bearing a covalently bound form of a vitamin E and/or vitamin D2. The cationic polymers exhibit high activity and selectivity against Gram-negative and Gram-positive microbes and fungi.Type: GrantFiled: April 9, 2013Date of Patent: June 19, 2018Assignees: International Business Machines Corporation, Agency For Science, Technology And ResearchInventors: Willy Chin, Daniel J. Coady, Amanda C. Engler, James L. Hedrick, Ashlynn L. Z. Lee, Victor W. L. Ng, Zhan-Yuin Ong, Yi Yan Yang
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Patent number: 9987369Abstract: Gel-forming block copolymers were prepared comprising i) a central hydrophilic block consisting essentially of a divalent poly(ethylene oxide) chain and ii) two peripheral monocarbonate or polycarbonate hydrophobic blocks linked to the central block by linking groups bearing one or more hydrogen bond forming *—N(H)—* groups. The hydrophobic blocks comprise one or more vitamin-bearing subunits. The gel-forming block copolymers can be used to prepare various biodegradable and/or biocompatible hydrogel and organogel drug compositions, in particular antimicrobial and/or anti-tumor drug compositions. The hydrogel compositions have utility in depot injections for drug delivery. The hydrogen bonding *—N(H)—* group(s) provide longer in vivo lifetime of the hydrogel before degradation and a more prolonged and controlled release rate of a hydrophobic drug compared to similar hydrogels prepared from poly(ethylene glycol).Type: GrantFiled: November 1, 2016Date of Patent: June 5, 2018Assignees: International Business Machines Corporation, Agency For Science, Technology And ResearchInventors: Wei Cheng, Mareva B. Fevre, James L. Hedrick, Nor Lizawati Ibrahim, Ashlynn L. Z. Lee, Victor W. L. Ng, Robert J. Ono, Chuan Yang, Yi Yan Yang
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Publication number: 20180117162Abstract: Gel-forming block copolymers were prepared comprising i) a central hydrophilic block consisting essentially of a divalent poly(ethylene oxide) chain and ii) two peripheral monocarbonate or polycarbonate hydrophobic blocks linked to the central block by linking groups bearing one or more hydrogen bond forming *—N(H)—* groups. The hydrophobic blocks comprise one or more vitamin-bearing subunits. The gel-forming block copolymers can be used to prepare various biodegradable and/or biocompatible hydrogel and organogel drug compositions, in particular antimicrobial and/or anti-tumor drug compositions. The hydrogel compositions have utility in depot injections for drug delivery. The hydrogen bonding *—N(H)—* group(s) provide longer in vivo lifetime of the hydrogel before degradation and a more prolonged and controlled release rate of a hydrophobic drug compared to similar hydrogels prepared from poly(ethylene glycol).Type: ApplicationFiled: November 1, 2016Publication date: May 3, 2018Inventors: Wei Cheng, Mareva B. Fevre, James L. Hedrick, Nor Lizawati Ibrahim, Ashlynn L.Z. Lee, Victor W.L. Ng, Robert J. Ono, Chuan Yang, Yi Yan Yang
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Patent number: 9951179Abstract: Eight-membered ring cyclic carbonates having an oxygen or an acylated nitrogen at position 6 were prepared by reaction of precursor diols with ethyl chloroformate. The cyclic carbonates undergo organocatalyzed ring opening polymerization. In one instance, the initial polymer formed comprises a carbonate repeat unit having a Boc-protected nitrogen in the polymer backbone. Deprotecting the nitrogen with acid forms a cationic carbonate repeat unit having a positive charged secondary ammonium nitrogen in the polymer backbone.Type: GrantFiled: February 20, 2017Date of Patent: April 24, 2018Assignees: International Business Machines Corporation, Agency For Science, Technology And ResearchInventors: Mareva B. Fevre, James L. Hedrick, Victor W. L. Ng, Robert J. Ono, Shrinivas Venkataraman, Yi Yan Yang
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Patent number: 9717797Abstract: Nanoparticles comprise a drug, a first block polymer and a second block polymer. The first block polymer has a poly(ethylene oxide) (PEO) block and a polycarbonate block bearing a side chain aromatic nitrogen-containing heterocycle (N-heterocycle). The N-heterocycle can be in the form of a base, a hydrosalt of the base, a sulfobetaine adduct of the base, or a combination thereof. The second block polymer has a PEO block and a polycarbonate block bearing a side chain catechol group, which can be present as a catechol, oxidized form of a catechol, and/or a polymerized form of a catechol. The nanoparticles can be dispersed in water and are capable of controlled release of the drug.Type: GrantFiled: December 5, 2013Date of Patent: August 1, 2017Assignees: International Business Machines Corporation, Agency For Science, Technology And Research, Universidad del París Vasco/Euskal Herriko UnibertsitateaInventors: Julian M. W. Chan, Amanda C. Engler, James L. Hedrick, Xiyu Ke, Victor W. L. Ng, Haritz Sardon, Jeremy P. K. Tan, Yi Yan Yang
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Publication number: 20170158811Abstract: Eight-membered ring cyclic carbonates having an oxygen or an acylated nitrogen at position 6 were prepared by reaction of precursor diols with ethyl chloroformate. The cyclic carbonates undergo organocatalyzed ring opening polymerization. In one instance, the initial polymer formed comprises a carbonate repeat unit having a Boc-protected nitrogen in the polymer backbone. Deprotecting the nitrogen with acid forms a cationic carbonate repeat unit having a positive charged secondary ammonium nitrogen in the polymer backbone.Type: ApplicationFiled: February 20, 2017Publication date: June 8, 2017Inventors: Mareva B. Fevre, James L. Hedrick, Victor W. L. NG, Robert J. Ono, Shrinivas Venkataraman, Yi Yan Yang
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Patent number: 9637592Abstract: Gel-forming block copolymers were prepared comprising i) a central hydrophilic block consisting essentially of a divalent poly(ethylene oxide) chain and ii) two peripheral monocarbonate or polycarbonate hydrophobic blocks. The hydrophobic blocks comprise one or more vitamin-bearing subunits. The vitamin-bearing subunits comprise a carbonate backbone portion and a side chain comprising a covalently bound form of a vitamin. The gel-forming block copolymers can be used to prepare various biodegradable and/or biocompatible hydrogel and organogel drug compositions, in particular antimicrobial and/or anti-tumor drug compositions. The hydrogel compositions can be suitable for depot injections. Synergistic enhancement of toxicity to microbes was observed with compositions comprising an antimicrobial cationic polymer and an antimicrobial compound.Type: GrantFiled: November 4, 2016Date of Patent: May 2, 2017Assignees: International Business Machines Corporation, Agency For Science, Technology And ResearchInventors: James L. Hedrick, Ashlynn L. Z. Lee, Victor W. L. Ng, Yi Yan Yang
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Patent number: 9631050Abstract: Antimicrobial cationic polymers having one or two cationic polycarbonate chains were prepared by organocatalyzed ring opening polymerization. One antimicrobial cationic polymer has a polymer chain consisting essentially of cationic carbonate repeat units linked to one or two end groups. The end groups can comprise a covalently bound form of biologically active compound such as cholesterol. Other antimicrobial cationic polymers have a random copolycarbonate chain comprising a minor mole fraction of hydrophobic repeat units bearing a covalently bound form of a vitamin E and/or vitamin D2. The cationic polymers exhibit high activity and selectivity against Gram-negative and Gram-positive microbes and fungi.Type: GrantFiled: May 14, 2016Date of Patent: April 25, 2017Assignees: International Business Machines Corporation, Agency For Science, Technology And ResearchInventors: Daniel J. Coady, Richard A. Dipietro, Amanda C. Engler, James L. Hedrick, Victor W. L. Ng, Zhan-Yuin Ong, Jeremy P. K. Tan, Yi Yan Yang
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Patent number: 9624191Abstract: Eight-membered ring cyclic carbonates having an oxygen or an acylated nitrogen at position 6 were prepared by reaction of precursor diols with ethyl chloroformate. The cyclic carbonates undergo organocatalyzed ring opening polymerization. In one instance, the initial polymer formed comprises a carbonate repeat unit having a Boc-protected nitrogen in the polymer backbone. Deprotecting the nitrogen with acid forms a cationic carbonate repeat unit having a positive charged secondary ammonium nitrogen in the polymer backbone.Type: GrantFiled: September 23, 2015Date of Patent: April 18, 2017Assignees: International Business Machines Corporation, Agency For Science, Technology And ResearchInventors: Mareva B. Fevre, James L. Hedrick, Victor W. L. Ng, Robert J. Ono, Shrinivas Venkataraman, Zhi Xiang Voo, Yi Yan Yang
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Publication number: 20170051105Abstract: Gel-forming block copolymers were prepared comprising i) a central hydrophilic block consisting essentially of a divalent poly(ethylene oxide) chain and ii) two peripheral monocarbonate or polycarbonate hydrophobic blocks. The hydrophobic blocks comprise one or more vitamin-bearing subunits. The vitamin-bearing subunits comprise a carbonate backbone portion and a side chain comprising a covalently bound form of a vitamin. The gel-forming block copolymers can be used to prepare various biodegradable and/or biocompatible hydrogel and organogel drug compositions, in particular antimicrobial and/or anti-tumor drug compositions. The hydrogel compositions can be suitable for depot injections. Synergistic enhancement of toxicity to microbes was observed with compositions comprising an antimicrobial cationic polymer and an antimicrobial compound.Type: ApplicationFiled: November 4, 2016Publication date: February 23, 2017Inventors: James L. Hedrick, Ashlynn L.Z. Lee, Victor W. L. Ng, Yi Yan Yang
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Patent number: 9511146Abstract: Gel-forming block copolymers were prepared comprising i) a central hydrophilic block consisting essentially of a divalent poly(ethylene oxide) chain and ii) two peripheral monocarbonate or polycarbonate hydrophobic blocks. The hydrophobic blocks comprise one or more vitamin-bearing subunits. The vitamin-bearing subunits comprise a carbonate backbone portion and a side chain comprising a covalently bound form of a vitamin. The gel-forming block copolymers can be used to prepare various biodegradable and/or biocompatible hydrogel and organogel drug compositions, in particular antimicrobial and/or anti-tumor drug compositions. The hydrogel compositions can be suitable for depot injections. Synergistic enhancement of toxicity to microbes was observed with compositions comprising an antimicrobial cationic polymer and an antimicrobial compound.Type: GrantFiled: April 28, 2015Date of Patent: December 6, 2016Assignees: International Business Machines Corporation, Agency For Science, Technology And ResearchInventors: James L. Hedrick, Ashlynn L. Z. Lee, Victor W. L. Ng, Yi Yan Yang
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Patent number: 9357772Abstract: Antimicrobial cationic polymers having one or two cationic polycarbonate chains were prepared by organocatalyzed ring opening polymerization. One antimicrobial cationic polymer has a polymer chain consisting essentially of cationic carbonate repeat units linked to one or two end groups. The end groups can comprise a covalently bound form of biologically active compound such as cholesterol. Other antimicrobial cationic polymers have a random copolycarbonate chain comprising a minor mole fraction of hydrophobic repeat units bearing a covalently bound form of a vitamin E and/or vitamin D2. The cationic polymers exhibit high activity and selectivity against Gram-negative and Gram-positive microbes and fungi.Type: GrantFiled: April 9, 2013Date of Patent: June 7, 2016Assignees: International Business Machines Corporation, Agency For Science, Technology And ResearchInventors: Daniel J. Coady, Richard A. Dipietro, Amanda C. Engler, James L. Hedrick, Victor W. L. Ng, Zhan-Yuin Ong, Jeremy P. K. Tan, Yi Yan Yang
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Publication number: 20160009860Abstract: Eight-membered ring cyclic carbonates having an oxygen or an acylated nitrogen at position 6 were prepared by reaction of precursor diols with ethyl chloroformate. The cyclic carbonates undergo organocatalyzed ring opening polymerization. In one instance, the initial polymer formed comprises a carbonate repeat unit having a Boc-protected nitrogen in the polymer backbone. Deprotecting the nitrogen with acid forms a cationic carbonate repeat unit having a positive charged secondary ammonium nitrogen in the polymer backbone.Type: ApplicationFiled: September 23, 2015Publication date: January 14, 2016Inventors: Mareva B. Fevre, James L. Hedrick, Victor W.L. Ng, Robert J. Ono, Shrinivas Venkataraman, Zhi Xiang Voo, Yi Yan Yang
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Publication number: 20150231257Abstract: Gel-forming block copolymers were prepared comprising i) a central hydrophilic block consisting essentially of a divalent poly(ethylene oxide) chain and ii) two peripheral monocarbonate or polycarbonate hydrophobic blocks. The hydrophobic blocks comprise one or more vitamin-bearing subunits. The vitamin-bearing subunits comprise a carbonate backbone portion and a side chain comprising a covalently bound form of a vitamin. The gel-forming block copolymers can be used to prepare various biodegradable and/or biocompatible hydrogel and organogel drug compositions, in particular antimicrobial and/or anti-tumor drug compositions. The hydrogel compositions can be suitable for depot injections. Synergistic enhancement of toxicity to microbes was observed with compositions comprising an antimicrobial cationic polymer and an antimicrobial compound.Type: ApplicationFiled: April 28, 2015Publication date: August 20, 2015Inventors: James L. Hedrick, Ashlynn L. Z. Lee, Victor W. L. Ng, Yi Yan Yang
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Publication number: 20150157723Abstract: Nanoparticles comprise a drug, a first block polymer and a second block polymer. The first block polymer has a poly(ethylene oxide) (PEO) block and a polycarbonate block bearing a side chain aromatic nitrogen-containing heterocycle (N-heterocycle). The N-heterocycle can be in the form of a base, a hydrosalt of the base, a sulfobetaine adduct of the base, or a combination thereof. The second block polymer has a PEO block and a polycarbonate block bearing a side chain catechol group, which can be present as a catechol, oxidized form of a catechol, and/or a polymerized form of a catechol. The nanoparticles can be dispersed in water and are capable of controlled release of the drug.Type: ApplicationFiled: December 5, 2013Publication date: June 11, 2015Applicants: International Business Machines Corporation, Universidad del Pais Vasco/Euskal Herriko Unibertsitatea, Agency For Science, Technology and ResearchInventors: Julian M. W. Chan, Amanda C. Engler, James L. Hedrick, Xiyu Ke, Victor W.L. Ng, Haritz Sardon, Jeremy P. K. Tan, Yi Yan Yang
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Patent number: 9040034Abstract: Gel-forming block copolymers were prepared comprising i) a central hydrophilic block consisting essentially of a divalent poly(ethylene oxide) chain and ii) two peripheral monocarbonate or polycarbonate hydrophobic blocks. The hydrophobic blocks comprise one or more vitamin-bearing subunits. The vitamin-bearing subunits comprise a carbonate backbone portion and a side chain comprising a covalently bound form of a vitamin. The gel-forming block copolymers can be used to prepare various biodegradable and/or biocompatible hydrogel and organogel drug compositions, in particular antimicrobial and/or anti-tumor drug compositions. The hydrogel compositions can be suitable for depot injections. Synergistic enhancement of toxicity to microbes was observed with compositions comprising an antimicrobial cationic polymer and an antimicrobial compound.Type: GrantFiled: April 9, 2013Date of Patent: May 26, 2015Assignees: International Business Machines Corporation, Agency for Science, Technology and ResearchInventors: James L. Hedrick, Ashlynn L. Z. Lee, Victor W. L. Ng, Yi Yan Yang
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Publication number: 20140301970Abstract: Gel-forming block copolymers were prepared comprising i) a central hydrophilic block consisting essentially of a divalent poly(ethylene oxide) chain and ii) two peripheral monocarbonate or polycarbonate hydrophobic blocks. The hydrophobic blocks comprise one or more vitamin-bearing subunits. The vitamin-bearing subunits comprise a carbonate backbone portion and a side chain comprising a covalently bound form of a vitamin. The gel-forming block copolymers can be used to prepare various biodegradable and/or biocompatible hydrogel and organogel drug compositions, in particular antimicrobial and/or anti-tumor drug compositions. The hydrogel compositions can be suitable for depot injections. Synergistic enhancement of toxicity to microbes was observed with compositions comprising an antimicrobial cationic polymer and an antimicrobial compound.Type: ApplicationFiled: April 9, 2013Publication date: October 9, 2014Applicants: INTERNATIONAL BUSINESS MACHINES CORPORATIONInventors: James L. Hedrick, Ashlynn L. Z. Lee, Victor W. L. Ng, Yi Yan Yang
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Publication number: 20140301967Abstract: Antimicrobial cationic polymers having one or two cationic polycarbonate chains were prepared by organocatalyzed ring opening polymerization. One antimicrobial cationic polymer has a polymer chain consisting essentially of cationic carbonate repeat units linked to one or two end groups. The end groups can comprise a covalently bound form of biologically active compound such as cholesterol. Other antimicrobial cationic polymers have a random copolycarbonate chain comprising a minor mole fraction of hydrophobic repeat units bearing a covalently bound form of a vitamin E and/or vitamin D2. The cationic polymers exhibit high activity and selectivity against Gram-negative and Gram-positive microbes and fungi.Type: ApplicationFiled: April 9, 2013Publication date: October 9, 2014Applicants: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH, INTERNATIONAL BUSINESS MACHINES CORPORATIONInventors: Willy Chin, Daniel J. Coady, Richard A. Dipietro, Amanda C. Engler, James L. Hedrick, Ashlynn L. Z. Lee, Victor W. L. Ng, Zhan-Yuin Ong, Yi Yan Yang