Abstract: Described herein are systems, devices and methods that enable dynamic modification of the physicochemical properties of a hydrogel during its in vivo formation and delivery by a catheter. In some example embodiments, an extended endoluminal hydrogel delivery device is employed for delivering a hydrogel within a given body cavity, such as within the lumen of a blood vessel. In some example embodiments, a hydrogel precursor, as a non-viscous liquid, is injected through an intravascular catheter and crosslinking of the hydrogel precursor is initiated within a distal region of the catheter. The crosslinking process is controlled, by a control means associated with a distal region of the catheter, to control or modify one or more properties of the hydrogel. The properties may be controlled such that a hydrogel is suitable to embolize the specific target or deliver drugs or other materials beneficial to the site.

Abstract: In certain example embodiments, provided is a compact massager, comprising: (1) one or more massage head attachment portions; and (2) a massager body, wherein the massager body is configured to connect with the one or more massage head attachment portions at the front body side, the massager body further comprises: (i) a motor; (ii) a PCBA; (iii) a display; (iv) a power source; wherein the power source is configured to electrically connect with the motor, the PCBA and the display; (v) a Z-shaped, transmission crank, configured to translate rotary motion from the motor to reciprocating motion of the one or more massage head attachment portions; and (vi) a counterweight, having an eccentric cam, an input shaft and an output shaft, wherein the input shaft is disposed at one side of the cam and is operatively connected to the motor, and an output shaft is disposed at an opposing side of the cam and is operatively connected to the transmission crank.

Abstract: A tethering system for a power tool and battery pack includes a first tethering attachment assembly configured to be attachable to a power tool, and a second tethering attachment assembly configured to be attachable to a battery pack, which is detachably couplable to a battery pack receptacle on the power tool. A first flexible connector has a first end configured to be attachable to the first tethering attachment assembly and a second end configured to be attachable to a stationary object. A second elongated flexible connector has a first end configured to be attachable to the second tethering attachment assembly and a second end configured to be attachable to the first tethering attachment assembly.

Abstract: A tethering system for a power tool and battery pack includes a first tethering attachment assembly configured to be attachable to a power tool, and a second tethering attachment assembly configured to be attachable to a battery pack, which is detachably couplable to a battery pack receptacle on the power tool. A first flexible connector has a first end configured to be attachable to the first tethering attachment assembly and a second end configured to be attachable to a stationary object. A second elongated flexible connector has a first end configured to be attachable to the second tethering attachment assembly and a second end configured to be attachable to the first tethering attachment assembly.

Abstract: Described herein are systems, devices and methods that enable dynamic modification of the physicochemical properties of a hydrogel during its in vivo formation and delivery by a catheter. In some example embodiments, an extended endoluminal hydrogel delivery device is employed for delivering a hydrogel within given body cavity, such as within the lumen of a blood vessels. In some example embodiments, a hydrogel precursor, as a non-viscous liquid, is injected through an intravascular catheter and crosslinking of the hydrogel precursor is initiated within a distal region of the catheter. The crosslinking process is controlled, by a control means associated with a distal region of the catheter, to control or modify one or more properties of the hydrogel. The properties may be controlled such that a hydrogel is suitable to embolize the specific target or deliver drugs or other materials beneficial to the site.

Abstract: A programmable therapeutic device for use with individualized massage therapy. The therapeutic device is capable of receiving and executing custom-made, individually tailored massage therapy scripts, for use with aiding users with effective pain and stress relief. The programmable therapeutic device may provide one or more of vibration, pulse, percussion, oscillation, electrical stimulation, and combinations thereof.

Abstract: A tethering system for a power tool and battery pack includes a first tethering attachment assembly configured to be attachable to a power tool, and a second tethering attachment assembly configured to be attachable to a battery pack, which is detachably couplable to a battery pack receptacle on the power tool. A first flexible connector has a first end configured to be attachable to the first tethering attachment assembly and a second end configured to be attachable to a stationary object. A second elongated flexible connector has a first end configured to be attachable to the second tethering attachment assembly and a second end configured to be attachable to the first tethering attachment assembly.

Abstract: Systems and methods are provided for optical topology detection and illumination. Embodiments provide an integrated system, and methods of operation thereof, where the integrated system includes an illumination system and an optical topology detection system, and where at least a portion of the spectral content of illumination light from the illumination system is within an optical detection bandwidth of the optical topology detection system, and where the operation of the optical topology detection system and the illumination system are interleaved to avoid crosstalk, such that the optical topology detection system detects the optical topology detection light when the illumination system is not emitting illumination light. The system may include, and control the operation of, an optical navigation system. The components of the system may be mounted to a rigid frame to maintain calibration.

Abstract: Embodiments of the invention disclosed herein generally relate to anti-cocaine therapeutics. Specifically, some embodiments of the invention relate to highly efficient, thermostable, and long-lasting cocaine esterase (CocE) mutants that can protect against the toxic and reinforcing effects of cocaine in subjects. Provided herein are mutant CocE polypeptides displaying thermostable esterase activity. Also provided are methods of treating cocaine-induced conditions in a subject in need via administration of mutant CocE as well as methods for high-throughput screening of candidate esterase polypeptides.

Abstract: Embodiments of the invention disclosed herein generally relate to anti-cocaine therapeutics. Specifically, some embodiments of the invention relate to highly efficient, thermostable, and long-lasting cocaine esterase (CocE) mutants that can protect against the toxic and reinforcing effects of cocaine in subjects. Provided herein are mutant CocE polypeptides displaying thermostable esterase activity. Also provided are methods of treating cocaine-induced conditions in a subject in need via administration of mutant CocE as well as methods for high-throughput screening of candidate esterase polypeptides.

Abstract: Systems and methods are provided for optical topology detection and illumination. Embodiments provide an integrated system, and methods of operation thereof, where the integrated system includes an illumination system and an optical topology detection system, and where at least a portion of the spectral content of illumination light from the illumination system is within an optical detection bandwidth of the optical topology detection system, and where the operation of the optical topology detection system and the illumination system are interleaved to avoid crosstalk, such that the optical topology detection system detects the optical topology detection light when the illumination system is not emitting illumination light. The system may include, and control the operation of, an optical navigation system. The components of the system may be mounted to a rigid frame to maintain calibration.

Abstract: Methods are provided for rendering an image of an anatomical object on a display of a mobile computing device. Sensors of the mobile computing device are interrogated to determine an orientation, or a change in orientation, of the computing device. Transformations are determined for rotating and positioning the image of the anatomical object such that the image appears to be stationary after a change in the orientation of the mobile computing device. Additional image data associated with a surgical tool or a surgical plan may also be rendered on the device for planning and/or training simulations.

Abstract: Methods are provided for rendering an image of an anatomical object on a display of a mobile computing device. Sensors of the mobile computing device are interrogated to determine an orientation, or a change in orientation, of the computing device. Transformations are determined for rotating and positioning the image of the anatomical object such that the image appears to be stationary after a change in the orientation of the mobile computing device. Additional image data associated with a surgical tool or a surgical plan may also be rendered on the device for planning and/or training simulations.

Abstract: Embodiments of the invention disclosed herein generally relate to anti-cocaine therapeutics. Specifically, some embodiments of the invention relate to highly efficient, thermostable, and long-lasting cocaine esterase (CocE) mutants that can protect against the toxic and reinforcing effects of cocaine in subjects. Provided herein are mutant CocE polypeptides displaying thermostable esterase activity. Also provided are methods of treating cocaine-induced conditions in a subject in need via administration of mutant CocE as well as methods for high-throughput screening of candidate esterase polypeptides.

Abstract: An improved construction for a heating element for an appliance is disclosed. A coiled resistance wire extending coaxially along the length of an elongate sheath is surrounded by an electrically insulating, high thermally conductive material that fills the sheath around the wire. The resistance wire is secured to a terminal pin at a connection comprising a connection insert that is securely affixed to the terminal pin, intermediate the terminal pin and resistance wire. The resistance wire is then able to be welded to the connector to provide a superior mechanical connection between a terminal pin and the resistance wire, even though the terminal pin is made from copper. The disclosed construction, therefore, provides good electrical and thermal conductivity and resists the tendency to separate during manufacture.

Abstract: Embodiments of the invention disclosed herein generally relate to anti-cocaine therapeutics. Specifically, some embodiments of the invention relate to highly efficient, thermostable, and long-lasting cocaine esterase (CocE) mutants that can protect against the toxic and reinforcing effects of cocaine in subjects. Provided herein are mutant CocE polypeptides displaying thermostable esterase activity. Also provided are methods of treating cocaine-induced conditions in a subject in need via administration of mutant CocE as well as methods for high-throughput screening of candidate esterase polypeptides.