Patents by Inventor Victoria Brophy

Victoria Brophy has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • IDENTIFICATION OF NON-RESPONDERS TO HER2 INHIBITORS
    Publication number: 20160265067
    Abstract: The present invention relates to means and methods for the identification of non-responders to a HER2 inhibitor, whereby one or more mutations in exon 9 of Phosphoinositol-3 kinase (PIK3CA) indicate non-responsiveness.
    Type: Application
    Filed: May 24, 2016
    Publication date: September 15, 2016
    Inventors: Victoria Brophy, Neil Jones, Astrid Kiermaier, Jayantha Ratnayake
  • Methods for detecting mutations in the catalytic subunit of the phosphoinositol-3 kinase (PIK3CA) gene
    Patent number: 9376715
    Abstract: The present invention relates to means and methods for the identification of non-responders to a HER2 inhibitor, whereby one or more mutations in exon 9 of Phosphoinositol-3 kinase (PIK3CA) indicate non-responsiveness.
    Type: Grant
    Filed: December 7, 2012
    Date of Patent: June 28, 2016
    Assignee: ROCHE MOLECULAR SYSTEMS, INC
    Inventors: Victoria Brophy, Neil Jones, Astrid Kiermaier, Jayantha Ratnayake
  • METHOD FOR VISUAL IDENTIFICATION OF PCR SOLUTIONS FOR ACCURATE REACTION SETUP
    Publication number: 20160053302
    Abstract: The present invention provides for methods and compositions that use visible dyes for the identification of reagents and solutions that are used to perform PCR assays.
    Type: Application
    Filed: April 16, 2015
    Publication date: February 25, 2016
    Inventors: Amar Gupta, Nancy Schoenbrunner, Kevin Janssen, Victoria Brophy
  • IDENTIFICATION OF NON-RESPONDERS TO HER2 INHIBITORS
    Publication number: 20150079076
    Abstract: The present invention relates to means and methods for the identification of non-responders to a HER2 inhibitor, whereby one or more mutations in exon 9 of Phosphoinositol-3 kinase (PIK3CA) indicate non-responsiveness.
    Type: Application
    Filed: December 7, 2012
    Publication date: March 19, 2015
    Applicant: ROCHE MOLECULAR SYSTEMS
    Inventors: Victoria Brophy, Neil Jones, Astrid Kiermaier, Jayantha Ratnayake
  • Nucleic acid amplification with allele-specific suppression of sequence variants
    Patent number: 8206929
    Abstract: The present invention is an improved method of selective amplification of certain variants of the target sequence, enhanced by allele-specific suppression of amplification of one or more of the other variants of the target sequence. The improvement is accomplished by providing an oligonucleotide, capable of hybridizing to the desired variant of the target sequence with the lesser affinity than to the undesired variants of the target sequence and optionally, by providing chemically modified primers and hot-start conditions.
    Type: Grant
    Filed: January 6, 2010
    Date of Patent: June 26, 2012
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Michael Grow, Victoria Brophy
  • NUCLEIC ACID AMPLIFICATION WITH ALLELE-SPECIFIC SUPPRESSION OF SEQUENCE VARIANTS
    Publication number: 20100173311
    Abstract: The present invention is an improved method of selective amplification of certain variants of the target sequence, enhanced by allele-specific suppression of amplification of one or more of the other variants of the target sequence. The improvement is accomplished by providing an oligonucleotide, capable of hybridizing to the desired variant of the target sequence with the lesser affinity than to the undesired variants of the target sequence and optionally, by providing chemically modified primers and hot-start conditions.
    Type: Application
    Filed: January 6, 2010
    Publication date: July 8, 2010
    Applicant: ROCHE MOLECULAR SYSTEMS, INC.
    Inventors: Michael Grow, Victoria Brophy
  • ASSOCIATION OF PDE4D ALLELIC VARIANTS WITH STROKE
    Publication number: 20070218472
    Abstract: The present invention provides methods for detecting a predisposition for stroke in individuals by correlating allelic variants of the phosphodiesterase 4D (PDE4D) gene and hypertension status. The invention further contemplates kits and computer program products for detecting PDE4D polymorphisms indicative of a predisposition for stroke correlated with an individual's hypertension status.
    Type: Application
    Filed: October 24, 2006
    Publication date: September 20, 2007
    Applicant: Roche Molecular Systems, Inc.
    Inventor: Victoria Brophy