Abstract: An absorbent extender tab insert that may be used with a diaper or incontinent article via a nylon hook component. The absorbent extender tab insert prevents leakage of bodily fluids beyond the existing structure of the diaper or incontinent article. The absorbent extender tab insert can attach and re-attach as needed and is washable and reusable in certain embodiments. Moreover, the absorbent extender tab insert can be placed at the front of, back of or on side of diaper as needed to prevent leakage of bodily fluids.

Abstract: Human ?2-antiplasmin (?2AP) is the major inhibitor of the proteolytic enzyme plasmin that digests fibrin. Two forms of ?2AP circulate in human plasma: a 464-residue protein, which we have termed “pro”-form, or ?2APpro and an N-terminally-shortened 452-residue “activated”-form, or ?2APact. The latter becomes crosslinked to fibrin by activated factor XIII about 5-fold more rapidly than ?2APpro and makes fibrin resistant to digestion by plasmin. A new human plasma proteinase has been identified herein that cleaves the Pro12-Asn13 bond of ?2APpro to yield ?2APact. This enzyme is identified herein as Antiplasmin Cleaving Enzyme (APCE). Novel inhibitors of circulating APCE can diminish ?2AP inhibitory capacity within forming fibrin or blood clots thereby making fibrin deposits or blood clots more susceptible to removal by plasmin.

Abstract: The present invention is directed toward inhibitors of antiplasmin cleaving enzyme for use in various therapies related to fibrin and ?2-antiplasmin, and to substrates of APCE, which may be used, for example, in screening methods for identifying such inhibitors. The present invention is further directed to methods of treating or inhibiting atherosclerosis and thrombus disorders by altering the rations of types of plasma ?2-antiplasmin.