Patents by Inventor Victoria Constandse

Victoria Constandse has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • System and method for isolation and qualification of nucleic acids
    Patent number: 11913062
    Abstract: Present disclosure provides a method including isolating DNA from a source, thereby providing a composition including the isolated DNA. The isolated DNA has at least first and second target regions, where the length of the second target region is greater than the length of the first target region. The method further includes quantifying a total mass of the isolated DNA, quantifying a first quantification cycle (Cq) of the first target region and a second Cq of the second target region, and calculating a Q-ratio for the isolated DNA by dividing the second Cq by the first Cq. The method further includes determining a value for a quality-mass constant (kQm), estimating a required input mass by dividing kQm by the Q-ratio, and preparing the isolated DNA for sequencing if the total mass of the isolated DNA in the composition is equal or greater than the required input mass.
    Type: Grant
    Filed: November 18, 2019
    Date of Patent: February 27, 2024
    Assignees: Roche Sequencing Solutions, Inc., Signature Diagnostics GmbH
    Inventors: Victoria Constandse, Daniel Klass, Alexander Lovejoy, Melissa Loyzer, Bronwen Miller, Bernd Hinzmann, Sophie Beckert
  • SYSTEM AND METHOD FOR ISOLATION AND QUALIFICATION OF NUCLEIC ACIDS
    Publication number: 20200087708
    Abstract: Present disclosure provides a method including isolating DNA from a source, thereby providing a composition including the isolated DNA. The isolated DNA has at least first and second target regions, where the length of the second target region is greater than the length of the first target region. The method further includes quantifying a total mass of the isolated DNA, quantifying a first quantification cycle (Cq) of the first target region and a second Cq of the second target region, and calculating a Q-ratio for the isolated DNA by dividing the second Cq by the first Cq. The method further includes determining a value for a quality-mass constant (kQm), estimating a required input mass by dividing kQm by the Q-ratio, and preparing the isolated DNA for sequencing if the total mass of the isolated DNA in the composition is equal or greater than the required input mass.
    Type: Application
    Filed: November 18, 2019
    Publication date: March 19, 2020
    Inventors: Victoria Constandse, Daniel Klass, Alexander Lovejoy, Melissa Loyzer, Bronwen Miller, Bernd Hinzmann, Sophie Beckert