Abstract: Methods, systems, and computer-readable media for batch processing with random access for transaction history are disclosed. A batch processing system receives a batch comprising records of events, including a first record of a first event and a second record of a second event. The system assigns the first and second records to a group based (at least in part) on determining that the events are related. The system determines that the group is related to a match set comprising one or more prior events. The system updates one or more values in the match set based (at least in part) on the first and second records. The system stores the updated match set and one or more additional match sets using a storage object. The system retrieves the match set and not the one or more additional match sets from the storage object using an index.

Abstract: Provided herein are nucleic acid molecules and vectors comprising variant copper transporting ATPase 2 (ATP7B) nucleic acid sequences. Such sequences have been optimized for expression in mammalian cells, liver cells, and/or from an adeno associated viral vector (AAV), including truncated and/or codon optimized variants. Also provided are viral vectors comprising such ATP7B variant nucleic acid sequences, and methods of use thereof for treating disorders associated with an ATP7B deficiency, such as Wilsons disease.

Abstract: Deferred revenue calculations can be necessary in an accrual-basis accounting model where a subscription or other type of sale is conducted that requires deferred revenue recognition. A snapshot state corresponding to the current state of a particular deferral can be generated. Out of order deferred events can also occur. The current state of the deferral can also be published in a downstream system.

Abstract: Certain biphenyic compounds are serotonin modulators useful in the treatment of serotonin-mediated diseases.

Abstract: Certain biphenyic compounds are serotonin modulators useful in the treatment of serotonin-mediated diseases.

Abstract: Certain biphenyic compounds are serotonin modulators useful in the treatment of serotonin-mediated diseases.

Abstract: Certain fused pyrrole- and pyrazole-containing heterocyclic compounds are serotonin modulators useful in the treatment of serotonin-mediated diseases.

Abstract: The invention provides novel non-peptidic NPY Y2 receptor inhibitors useful in treating or preventing: anxiolytic disorders or depression; injured mammalian nerve tissue; conditions responsive to treatment through administration of a neurotrophic factor; neurological disorders; bone loss; substance related disorders; sleep/wake disorders; cardiovascular disease; obesity; or an obesity-related disorder. Compounds of the invention are also useful in modulating endocrine functions, particularly endocrine functions controlled by the pituitary and hypothalamic glands, and are therefore useful in the treatment or prevention of inovulation and infertility.

Abstract: Novel nucleic acid sequences encoding hemipteran L-glutamate decarboxylases, and the amino acid sequence of such protein are disclosed. Methods of making and using the same are disclosed.

Abstract: A method, system and apparatus for partial credential processing for limited commerce system interactions. The method can include identifying a visitor to a commerce system as an unauthenticated albeit registered user of the commerce system. Subsequently, the visitor can be provided access to a limited subset of commerce data for the registered user under an un-trusted identity. In the course of the visitor interacting with the commerce system, additional commerce data, such as shopping cart data, can be generated under the un-trusted identity until the visitor authenticates with the commerce system. When the visitor authenticates with the commerce system, a full set of the commerce data for the registered user under a trusted identity can be provided. Additionally, the generated additional commerce data can be merged under the un-trusted identity with the commerce data for the registered user under the trusted identity.

Abstract: Certain fused pyrrole- and pyrazole-containing heterocyclic compounds are serotonin modulators useful in the treatment of serotonin-mediated diseases.

Abstract: A compound is provided for inactivating viral, bacterial or other contamination in cells, body fluids or fractions thereof. The compound comprises a psoralen with a single substituent that is either a quaternary phosphonium or ammonium moiety, and at least one substituent that is a halogen. The compound selectively binds to the contaminant, and upon activation by irradiation, damages the contaminant.

Abstract: A method is provided for inactivating viral and/or bacterial and/or parasitic contamination in cellular blood matter or blood plasma protein fractions, using radiation sensitizing chemical compounds and irradiation with, for example, UV radiation.

Abstract: A process and medium are disclosed for the lyophilization of cells, specifically platelets, and cell-like matter, which comprises the use of solutions including monosaccharide hexoses and pentoses, and biocompatible amphipathic polymers to permit the reconstitution of transfusably useful cells, specifically platelets, and cell-like matter.