Abstract: The present invention relates to binding molecules comprising (i) one or more polypeptides which form a binding site capable of binding a target molecule and (ii) an Fc effector peptide displaying one or more effector functions associated with the constant region (Fc) of an immunoglobulin heavy chain. The invention further relates to novel Fc effector peptides and nucleic acid molecules encoding said binding molecules and Fc effector peptides. The invention further relates to therapeutic uses of said binding molecules and pharmaceutical compositions containing said binding molecules.