Abstract: The present invention relates to compounds of the general formula (I) their pharmaceutically acceptable salts, pharmaceutically acceptable solvates, enantiomers, diastereomers, and polymorphs. The invention also relates to processes for the preparation of the compounds of invention, pharmaceutical compositions containing the compounds and their use as Autotaxin (ATX) inhibitors.

Abstract: A frame assembly for a motor vehicle that may include a first load beam, a second load beam, and a frame rail that are configured for receipt and transfer of energy to a sill that can move the sill in a downward direction. A counterbalancing load beam that includes a first fixed end is attached to the first load beam and a second fixed end is attached to the frame rail. The counterbalancing load beam is configured for receipt of at least a portion of the energy applied to the first load beam, and the counterbalancing load beam is configured to transfer the energy received from the first load beam to the frame rail such that the transfer of energy to the sill that can move the sill in the downward direction is counterbalanced by the energy transferred by the counterbalancing load beam to the frame rail.

Abstract: A frame assembly for a motor vehicle that may include a first load beam, a second load beam, and a frame rail that are configured for receipt and transfer of energy to a sill that can move the sill in a downward direction. A counterbalancing load beam that includes a first fixed end is attached to the first load beam and a second fixed end is attached to the frame rail. The counterbalancing load beam is configured for receipt of at least a portion of the energy applied to the first load beam, and the counterbalancing load beam is configured to transfer the energy received from the first load beam to the frame rail such that the transfer of energy to the sill that can move the sill in the downward direction is counterbalanced by the energy transferred by the counterbalancing load beam to the frame rail.

Abstract: An enhanced pipeline for the generation, validation, and deployment of machine-based predictive models (PMs) is provided. The pipeline analyzes records to generate a graph that indicates various relationships between the records. A user provides a selection of a data element of interest (DEOI). The generated PM predicts values for the DEOI based on input records that do not include values for the DEOI. The user provides selections for values of the DEOI that represent positive outcomes associated with the DEOI. The user provides selections for values of the DEOI that represent negative outcomes associated with the DEOI. A subgraph of the graph is determined based on the DEOI. A relevant set of records is determined based on the subgraph. The PM is automatically trained, validated, and deployed based on the relevant set of records, the DEOI, and the representative values for the DEOI.

Abstract: Compositions and methods are provided for increasing methionine content in plants are disclosed.

Abstract: The present invention is directed to a composition comprising a gelling agent and an at least one oil, wherein the oil and gelling agent are in a ratio of about 2 to about 16.

Abstract: Compositions and methods are provided for increasing methionine content in plants are disclosed.

Abstract: The present invention relates to an improved process for the preparation of 3-(N-methyl-2(R)-pyrrolidinyl methyl)-5-[2-(phenyl sulfonyl)ethyl]-1H-indole or pharmaceutically acceptable salts thereof, particularly 3-(N-methyl-2(R)-pyrrolidinyl methyl)-5-[2-(phenyl sulfonyl)ethyl]-1H-indole hydrobromide (Eletriptan hydrobromide). The present invention further relates to novel polymorphs of 3-(N-methyl-2(R)-pyrrolidinyl methyl)-5-[2-(phenyl sulfonyl)ethenyl]-1H-indole hydrobromide and process for preparation thereof.

Abstract: A water soluble cosmetic or pharmaceutical or pharmaceutical actives in an electrolyte solution which, when impregnated with one or more retentive fillers (such as, for example, silica or hydrophobically modified silica, lamellar filler, crosspolymer, cellulosic, resins, or silicone elastomers) can form stable solid compositions with structurants. Such solid compositions do not require a higher buffer pH or leave residues upon application to the skin. Solid compositions according to the present invention are suitable for cosmetic and pharmaceutical purposes such as antiperspirants, deodorants, lip products, and other topical applications.

Abstract: The present invention relates to a process for preparation and purification of 3-[2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one, also known as paliperidone or 9-hydroxy risperidone. The invention also relates to the preparation of intermediates useful in the process.

Abstract: The present invention provides a process for resolving racemic pregabalin to S-pregabalin by using a chiral acid to form a pregabalin salt, purifying the salt to obtain a purified S- pregabalin salt then neutralizing the salt to obtain S-pregabalin having good chiral purity.

Abstract: A clear gel emulsion antiperspirant or deodorant composition comprising at least one antiperspirant or deodorant active, a water phase, and an oil phase containing at least one high refractive index oil, wherein the composition is prepared from an oil phase and a water phase that, prior to emulsification, are both optically clear; a clear gel emulsion antiperspirant or deodorant composition containing at least one polymeric alpha olefin in the oil phase; and a method for improving the clarity of a clear gel emulsion antiperspirant or deodorant composition.

Abstract: A system and method for identifying crawl paths of a web cruise operation, where each crawl path represents successive uniform resource locator (URL) nodes in a parent/child relationship. One or more seed URLs are identified for the web cruise operation, each seed URL defining an origination of at least one crawl path. A set of attributes of each parent URL in each crawl path are identified to be inherited by one or more child URLs found in the web cruise operation. Then, each child URL is associated with the set of attributes identified for all parent URLs in the crawl path.

Abstract: An antiperspirant composition comprising at least one antiperspirant or deodorant active and at least one retentive filler, where the active is solubilized in a polar solvent and contained within the at least one retentive filler and a method for treating skin.

Abstract: Multi-layered compositions having a plurality of pillared metal complexes disposed on a supporting substrate, the pillars comprising divalent electron acceptor moieties with a phosphonate or arsenate at each end. Each layer of parallel pillars is separated by a layer of a group (IVA), (IVB), (IIIA) or (IIIB) metal or a lanthanide. The compositions can further comprise particles of at least one Group VIII metal at zero valence entrapped within each layer of the complex. The complexes can also incorporate "stalactites" and "stalagmites" of capped arsonato or phosphonato ligands interspersed with the pillars providing a series of interstices about each electron accepting group. The supporting substrate can be comprised of an organic polymer template. The complexes are useful for the conversion and storage of solar energy, for the production of photocurrents, and as catalysts for reduction reactions, for example, the production of hydrogen peroxide from oxygen and hydrogen gases, the production of H.sub.

Abstract: A method for the production of hydrogen peroxide from a source of hydrogen and a source of oxygen in the presence of a catalyst comprising the formula:(Y.sup.1 O.sub.3 --Z--Y.sup.2 O.sub.3)(Y.sup.3 O.sub.3 R.sup.3)MeY.sup.1, Y.sup.2 and Y.sup.3 being phosphorus or arsenic; Z being a divalent group containing two conjugated cationic centers; R.sup.3 being a capping group and Me being a trivalent or tetravalent metal.