Abstract: A refrigeration unit includes a cabinet and a first evaporator assembly. The first evaporator assembly is operable between an uninstalled condition and an installed condition. In the uninstalled condition, the first evaporator assembly is not assembled with the cabinet. In the installed condition, the first evaporator assembly is assembled with the cabinet. The first evaporator assembly includes a first evaporator, a first suction line connected to the first evaporator at a first suction line joint, and a first capillary tube connected to the first evaporator at a first capillary tube joint. The first suction line joint and the first capillary tube joint of the first evaporator assembly are leak testable in the uninstalled condition of the first evaporator assembly.

Abstract: The present invention relates to an inhalable composition comprising a therapeutically effective dosage amount of compound (I), 2-{4-[(2S)-1,1-difluoro-2-hydroxypropyl]phenyl}-N-{4-[3-(2-ethylphenyl) pyrazine-2-yl]phenyl}acetamide or a pharmaceutically acceptable salt thereof. Particularly, the present invention relates to a inhalable dry powder composition comprising compound (I) or a pharmaceutically acceptable salt thereof. Further, the present invention relates to a method of treating a pulmonary disease using such a composition.

Abstract: Devices and methods for multi-resolution geometric representation for ray tracing are described which include casting a ray in a space comprising objects represented by geometric shapes and approximating a volume of the geometric shapes using an accelerated hierarchy structure. The accelerated hierarchy structure comprises first nodes each representing a volume of one of the geometric shapes in the space and second nodes each representing an approximate volume of a group of the geometric shapes. When the ray is determined to intersect a bounding box of a second node representing one group of the geometric shapes, a selection is made between traversal and non-traversal of other second nodes based on a LOD for representing the volume of the one group of geometric shapes.

Abstract: A co-rotating twin screw processor for preparing dry granules including an input zone having one or more powder feeders for feeding an input material into the processor, a steam feeder configured to introduce steam as a granulation activating agent in to the processor, a granulation zone for granulating the input material in the presence of steam to form granules, a controller configured to control operation and feed rate of at least one of the powder feeder or the steam feeder such that 2.5 to 5 percent w/w of the steam with respect to the input material is available for granulation, and a discharge zone haring a non-extruding opening for collecting dry granules.

Abstract: Systems and methods are described for providing context for software deployment using augmented reality. In an example method, an augmented reality (AR) device having one or more processors may receive a set of compatibility requirements for deployment of a computer executable program (e.g., a software). A camera may acquire image data of a first video showing one or more computing devices. A respective device identifier corresponding to each computing device may be determined. Based on each device identifiers, a respective device specification may be received for each computing device. The set of compatibility requirements may be compared with each of the device specifications. The AR device may generate one or more annotation labels indicating a respective compatibility value for each computing device. Furthermore, the AR device may generate, in real time, an augmented video by mapping the annotation labels to the computing devices.

Abstract: The present disclosure concerns effervescent compositions and methods of making and using the same. In some embodiments, the disclosed effervescent compositions are formed from an input blend comprising an acid and a base by granulating the input blend in a twin-screw processor. The granules formed from the input blend can be formed by an in situ granulating agent, which can be a portion of the acid that melts during granulation. In some embodiments, the effervescent compositions can be made using a twin-screw processor comprising an intake zone for receiving an input blend comprising an acid and a base; a granulation initiation zone for melting only a portion of the acid to serve as an in situ granulating agent; a granulation completion zone for granulating the input blend; and an outlet for discharging the granules.

Abstract: Systems and methods for providing a financial/clinical data interchange are provided. The financial/clinical data interchange provides a distributed implementation to a secure hash key (i.e., a token) and value pair data derived from a medical claim (e.g., patient identification, submitter identification, payer identification, encounter identification, and the like) and enriched with submitter-based domain data. The token may be used as a data attribute in an API that unlocks a pointer to the value (e.g., a fast healthcare interoperability resources (FHIR) uniform resource identifier (URI) to the patient encounter associated with the claim) to leverage a FHIR query for all documented medical records associated with the claim the payer is authorized by the submitter to view.

Abstract: A fractional lobe processor comprises a barrel with heating and cooling means having two parallel intersecting bores of equal diameter, wherein the centre distance between the two bores is lesser than the diameter of the bore; a shaft coupled with a plurality of screw elements to form a screw within each bore, wherein the screws are intermeshing and form at least three zones within the barrel, the zones comprising an intake zone comprising at least one deep flighted shovel element on each intermeshing screw for receiving a feed comprising an active substance and/or an excipient, a melt zone consisting of only fractional lobe elements for melting the active substance and/or an excipient to form a viscous mass or melt, and a discharge zone, wherein the melt zone is located before the discharge zone and after the intake zone; and wherein the melt zone has a plurality of fractional lobe elements on each shaft.

Abstract: Systems and methods are described for providing context for software deployment using augmented reality. In an example method, an augmented reality (AR) device having one or more processors may receive a set of compatibility requirements for deployment of a computer executable program (e.g., a software). A camera may acquire image data of a first video showing one or more computing devices. A respective device identifier corresponding to each computing device may be determined. Based on each device identifiers, a respective device specification may be received for each computing device. The set of compatibility requirements may be compared with each of the device specifications. The AR device may generate one or more annotation labels indicating a respective compatibility value for each computing device. Furthermore, the AR device may generate, in real time, an augmented video by mapping the annotation labels to the computing devices.

Abstract: The present disclosure concerns effervescent compositions and methods of making and using the same. In some embodiments, the disclosed effervescent compositions are formed from an input blend comprising an acid and a base by granulating the input blend in a twin-screw processor. The granules formed from the input blend can be formed by an in situ granulating agent, which can be a portion of the acid that melts during granulation. In some embodiments, the effervescent compositions can be made using a twin-screw processor comprising an intake zone for receiving an input blend comprising an acid and a base; a granulation initiation zone for melting only a portion of the acid to serve as an in situ granulating agent; a granulation completion zone for granulating the input blend; and an outlet for discharging the granules.

Abstract: Methods for granulating powder in a single piece of equipment include at least the following: (a) continuously introducing the powder and a granulating fluid to the single piece of equipment; (b) passing the powder and the granulating fluid through a granulating zone of the single piece of equipment to form wet granules; (c) passing the wet granules through a drying zone of the single piece of equipment; (d) optionally passing granules through a discharge zone of the single piece of equipment; and (e) continuously discharging the granules from the single piece of equipment where the single piece of equipment is not a fluid bed processor.

Abstract: Methods for granulating a pharmaceutical powder in a single piece of equipment include at least the following: (a) continuously introducing the pharmaceutical powder and a granulating fluid to the single piece of equipment, (b) passing the pharmaceutical powder and the granulating fluid through a granulating zone of the single piece of equipment to form wet granules, (c) passing the wet granules through a drying zone of the single piece of equipment, (d) optionally passing granules through a discharge zone of the single piece of equipment, and (e) continuously discharging the granules from the single piece of equipment where the single piece of equipment is not a fluid bed processor.

Abstract: A fractional lobe processor is disclosed. The fractional lobe processor comprises an intake zone comprising at least one deep flighted shovel element on each intermeshing screw for receiving a input blend comprising an active substance and an excipient; a granulation zone consisting of only fractional lobe elements, and having a provision for introducing moisture or a binder solution, for granulating the active substance and the excipient; an optional, drying zone for drying the wet granules; and a discharge zone for discharging the granules; wherein the granulation zone is located before the discharge zone and after the intake zone; wherein the drying zone has one or more fractional lobe elements on each shaft; and wherein the granulation zone has a plurality of fractional lobe elements on each shaft.

Abstract: The present invention relates to effervescent compositions of Metformin and optionally other anti-diabetic agents and processes for preparation thereof. More particularly provides an effervescent composition comprising Metformin, an acid and a base such that the composition is free of affirmatively added binders and granulating solvents. The effervescent composition of the present invention has retained carbon dioxide content of at least 90% of the input blend.

Abstract: An analog to digital (A/D) converter includes a capacitor array having respective first terminals selectively coupled to a reference voltage or ground via a plurality of switches and having respective second terminals coupled to a sample and hold (S/H) output. The A/D converter also includes a voltage comparator having a first input coupled to the S/H output and having a second input coupled to a bias voltage. The voltage comparator is configured to output a comparison voltage responsive to a sampled charge at the S/H output and the bias voltage. The A/D converter also includes a successive approximation register coupled to receive the comparison voltage and configured to output an approximate digital code responsive to the comparison voltage, wherein the approximate digital code is varied by controlling an equivalent capacitance of the capacitor array.

Abstract: An integrated self-test mechanism for monitoring an analog-to-digital converter (ADC), a reference voltage (Vref) source associated with the ADC, a low-dropout regulator (LDO), or a power supply is provided. In one example, an ADC that is associated with an integrated circuit (IC) can monitor its own Vref, the voltage (VLBO) of an LDO associated with the IC, or the voltage (AVDD) provided to an electrical coupling mechanism in the IC that is coupled to a power supply associated with the IC. The ADC can generate a digital output code based, at least in part, on the Vref and one or more of the VLBO and the AVDD. The digital output code can be used to determine whether one or more of the ADC, the Vref source, the LDO, and the power supply is malfunctioning or nonoperational.

Abstract: A device includes a capacitive digital to analog converter (CDAC) that further includes a plurality of capacitors to sample an analog input signal. The sampled analog input signal is converted into a digital signal and the digital signal is stored by a successive approximation register (SAR). Thereafter, the SAR regenerates the stored digital signal to a reset plurality of capacitors, and a comparator is configured as an amplifier to generate an equivalent analog voltage of the stored digital signal.

Abstract: A method for testing an A/D converter with a built-in diagnostic circuit with a user supplied variable input voltage includes generating a charge by a binary-weighted capacitor array responsive to an external voltage and a user specified code. The method further includes applying the charge to a first input of a voltage comparator and applying a bias voltage to a second input of the voltage comparator, and generating, by the voltage comparator, a comparison voltage responsive to the applied charge and the bias voltage. The method also includes applying the comparison voltage to an input of a successive approximation register and generating, by the successive approximation register, an approximate digital code responsive to the comparison voltage. The method also includes determining if at least one bit of the approximate digital code fails to toggle independent of adjacent bits.

Abstract: A method for testing an A/D converter with a built-in diagnostic circuit with a user supplied variable input voltage includes generating a charge by a binary-weighted capacitor array responsive to an external voltage and a user specified code. The method further includes applying the charge to a first input of a voltage comparator and applying a bias voltage to a second input of the voltage comparator, and generating, by the voltage comparator, a comparison voltage responsive to the applied charge and the bias voltage. The method also includes applying the comparison voltage to an input of a successive approximation register and generating, by the successive approximation register, an approximate digital code responsive to the comparison voltage. The method also includes determining if at least one bit of the approximate digital code fails to toggle independent of adjacent bits.

Abstract: The present disclosure relates to a process for preparing granules from an input material or a powder material. The process comprises feeding the input material for granulation in the processor using one or more powder feeders, introducing steam as a granulation activating agent in the processor, granulating the input material in presence of the steam to form granules, and optionally collecting the granules from a discharge zone of the processor, wherein feed rate of the steam into the processor is determined based on feed rate of the input material into the processor. A co-rotating twin-screw processor for preparing granules is also disclosed.