Abstract: Described herein are methods of determining segregation dynamics of mitochondrial DNA herein. Also described herein are methods of diagnosing, prognosing, and/or monitoring a mitochondrial disease.

Abstract: Embodiments disclosed herein provide methods of using somatic mutations in mitochondrial genomes to retrospectively infer cell lineages in native contexts and to serve as genetic barcodes to measure clonal dynamics in complex cellular populations. Further, somatic mutations in mitochondrial DNA (mtDNA) are tracked by single cell genomic approaches for simultaneous analysis of single cell lineage and state. Applicants further show that mitochondrial mutations can be readily detected with contemporary single cell transcriptomic and epigenomic technologies to concomitantly capture gene expression profiles and chromatin accessibility, respectively.

Abstract: An apparatus includes a processor and a plurality of on-board diagnostic (OBD) interfaces, in communication with the processor. The exemplary apparatus also includes a configurable housing, adapted to flexibly present an orientation of an OBD interface. The apparatus further includes persistent and non-persistent memory, in communication with the processor and a non-OBD I/O interface, in communication with the processor. The processor is configured to detect external device communication through a first OBD interface and function as a pass-through to a second OBD interface.

Abstract: An apparatus includes a processor and a plurality of on-board diagnostic (OBD) interfaces, in communication with the processor. The exemplary apparatus also includes a configurable housing, adapted to flexibly present an orientation of an OBD interface. The apparatus further includes persistent and non-persistent memory, in communication with the processor and a non-OBD I/O interface, in communication with the processor.

Abstract: A method includes receiving a metrology report including metrology data collected by a metrology tool, position data associated with the metrology data, and context data associated with the metrology tool. A first coordinate system employed by the metrology tool is determined based on the context data. The position data is transformed from the first coordinate system to a second coordinate system to generate transformed position data. The transformed position data is associated with the metrology data.

Abstract: A method includes receiving a metrology report including metrology data collected by a metrology tool, position data associated with the metrology data, and context data associated with the metrology tool. A first coordinate system employed by the metrology tool is determined based on the context data. The position data is transformed from the first coordinate system to a second coordinate system to generate transformed position data. The transformed position data is associated with the metrology data.