Abstract: A method for veterinary administration of medication to an animal, particularly a horse, is disclosed. The method involves inserting a capsule containing the medication, which is a liquid formulation, into a device connected to a tubular chamber. An atomizer is activated to atomize the medication, producing atomized medication. Before administration, a force is applied to a mask placed over the animal's muzzle, connected to the chamber. The atomized medication is then delivered to the animal. The liquid formulation, in some instances, comprises cells, cellular byproducts, or cell-derived products such as stem cells or products from human mesenchymal stem cells. This formulation may lack preservatives and may encompass peptides, proteins, growth factors, cytokines, exosomes, and extracellular vesicles. The delivery mechanism may involve deflating an air bladder to convey the atomized medication.

Abstract: The invention pertains to a capsule system for use with a medical device designed to administer atomized medication to patients. The system features a chamber containing the medication and an atomizer at a lower end for efficient drug delivery. Notably, the system incorporates a fluid sensor and electrical contacts to ensure proper operation and medication delivery. The capsule's design includes a housing with an asymmetrical transverse cross-sectional shape for unique fitting, and a tapered wall to direct medication towards the atomizer. The capsule may also connect to an external container or include a stopper for refilling medication. A specific embodiment features two chambers with a rupturing element to facilitate medication transfer. Another embodiment includes a removable container, like a vial, within the first chamber. This novel system provides improvements in accuracy, versatility, and user-friendliness, overcoming limitations in prior art.

Abstract: Therapeutics and methods of treatment to repair, preserve and grow cartilage are presented. In addition, systems and methods for delivering a therapeutic to a hard to reach anatomical area, such as, for example, the BCI, are presented. A cannulated delivery device provided with a cutting tip, cutting flutes and threads on its distal end can be provided. Using such an exemplary device, various novel therapies for joint and cartilage repair, preservation and generation can be implemented. The device may have two-needles, with a first cannula/needle, with a finger grip at its distal end, and a longer inner needle to penetrate through the outer needle into the disc, and introduce therapeutics, for example, via a syringe. When provided with a septum at the inner needle's proximal end, the PIARES device is a completely closed system, and its use minimizes trauma.

Abstract: A system for administering at least one medication to a patient is disclosed. The system includes a resilient air bladder in fluid communication with a tubular chamber of a base unit, a capsule in fluid communication with the tubular chamber configured for carrying the at least one medication, and an atomizer disposed at least proximate to the capsule and in fluid communication with the tubular chamber. An air inlet and a first one-way valve is in fluid communication with the resilient air bladder configured to allow fresh air to enter the resilient air bladder. An air outlet and a second one-way value is in fluid communication the resilient air bladder and the tubular chamber. Fresh air and the medication atomized by the atomizer mix together within the tubular chamber.

Abstract: A method is disclosed for administering medication to conscious or unconscious patients using a device with a tubular chamber. The method involves the use of a device with a tubular chamber, wherein a liquid medication is contained within a capsule. The medication is atomized by activating an atomizer, thereby generating an atomized medication consisting of particles with a maximum diameter of four microns. The atomized medication is then dispensed into the tubular chamber. Using the device, the atomized medication is administered to the patient. In cases of unconsciousness, a resilient air bladder connected to the chamber is partially deflated, allowing air transfer into the chamber. This facilitates the administration of the atomized medication. This method enables effective medication delivery in various emergency scenarios, ensuring appropriate treatment even for unresponsive patients by providing a method of using a device with modular components.

Abstract: Therapeutics and methods of treatment to repair, preserve and grow cartilage are presented. In addition, systems and methods for delivering a therapeutic to a hard to reach anatomical area, such as, for example, the BCI, are presented. A cannulated delivery device provided with a cutting tip, cutting flutes and threads on its distal end can be provided. Using such an exemplary device, various novel therapies for joint and cartilage repair, preservation and generation can be implemented. The device may have two-needles, with a first cannula/needle, with a finger grip at its distal end, and a longer inner needle to penetrate through the outer needle into the disc, and introduce therapeutics, for example, via a syringe. When provided with a septum at the inner needle's proximal end, the PIARES device is a completely closed system, and its use minimizes trauma.

Abstract: Therapeutics and methods of treatment to repair, preserve and grow cartilage are presented. In addition, systems and methods for delivering a therapeutic to a hard to reach anatomical area, such as, for example, the BCI, are presented. A cannulated delivery device provided with a cutting tip, cutting flutes and threads on its distal end can be provided. Using such an exemplary device, various novel therapies for joint and cartilage repair, preservation and generation can be implemented. The device may have two-needles, with a first cannula/needle, with a finger grip at its distal end, and a longer inner needle to penetrate through the outer needle into the disc, and introduce therapeutics, for example, via a syringe. When provided with a septum at the inner needle's proximal end, the PIARES device is a completely closed system, and its use minimizes trauma.

Abstract: Therapeutics and methods of treatment to repair, preserve and grow cartilage are presented. In addition, systems and methods for delivering a therapeutic to a hard to reach anatomical area, such as, for example, the BCI, are presented. A cannulated delivery device provided with a cutting tip, cutting flutes and threads on its distal end can be provided. Using such an exemplary device, various novel therapies for joint and cartilage repair, preservation and generation can be implemented. The device may have two-needles, with a first cannula/needle, with a finger grip at its distal end, and a longer inner needle to penetrate through the outer needle into the disc, and introduce therapeutics, for example, via a syringe. When provided with a septum at the inner needle's proximal end, the PIARES device is a completely closed system, and its use minimizes trauma.

Abstract: A method of making mammalian chondroblast cells or progenitors thereof and a method for their use. A method of making exosomes and signaling factors and a method for their use.

Abstract: Therapeutics and methods of treatment to repair, preserve and grow cartilage are presented. In addition, systems and methods for delivering a therapeutic to a hard to reach anatomical area, such as, for example, the BCI, are presented. A cannulated delivery device provided with a cutting tip, cutting flutes and threads on its distal end can be provided. Using such an exemplary device, various novel therapies for joint and cartilage repair, preservation and generation can be implemented. Alternatively, for disc repair, a delivery device directed to percutaneous intradiscal annular repair, or “PIARES” device can be used to introduce therapeutics intradiscally. The device may have two-needles, with a first cannula/needle, with a finger grip at its distal end, and a longer inner needle to penetrate through the outer needle into the disc, and introduce therapeutics, for example, via a syringe.

Abstract: Therapeutics and methods of treatment to repair, preserve and grow cartilage are presented. In addition, systems and methods for delivering a therapeutic to a hard to reach anatomical area, such as, for example, the BCI, are presented. A cannulated delivery device provided with a cutting tip, cutting flutes and threads on its distal end can be provided. Using such an exemplary device, various novel therapies for joint and cartilage repair, preservation and generation can be implemented. Alternatively, for disc repair, a delivery device directed to percutaneous intradiscal annular repair, or “PIARES” device can be used to introduce therapeutics intradiscally. The device may have two-needles, with a first cannula/needle, with a finger grip at its distal end, and a longer inner needle to penetrate through the outer needle into the disc, and introduce therapeutics, for example, via a syringe.

Abstract: A back support system has a belt portion that is configured to provide back and abdominal support encircling a wearer's waist, a compression pants portion and a hot or cold pack providing therapy to a wearer's lumbosacral region. The belt portion has left and right portions and a rear portion that extends upwardly from a cutout of the rear portion of the compression pants and it is attached fixedly to it. The rear portion of the belt portion has a pack support structure for receiving a hot or cold pack so as to maintain hot or cold therapy on the wearer's back. A front core support structure provides abdominal support that in combination with the back support supports the entire core of the wearer's body. The garment can be changed to an immobilizing brace device by inserting optional rigid inserts.

Abstract: Therapeutics and methods of treatment to repair, preserve and grow cartilage are presented. In addition, systems and methods for delivering a therapeutic to a hard to reach anatomical area, such as, for example, the BCI, are presented. A cannulated delivery device provided with a cutting tip, cutting flutes and threads on its distal end is disclosed, as well as therapies for joint and cartilage repair, preservation and generation using it. Alternatively, for disc repair, a “PIARES” device for Percutaneous Intradiscal Annular Repair introduces therapeutics intradiscally. The device may have two-needles; a first cannula/needle with a finger grip, and a longer inner needle to penetrate through the outer needle into the disc, and introduce therapeutics via a syringe. When provided with a septum at the inner needle's proximal end, the PIARES device is a completely closed system; using it minimizes trauma.

Abstract: A back support system that comprises a belt portion being configured to provide back and abdominal support encircling a wearer's waist, a compression pants portion and a hot or cold pack providing therapy to a wearer's lumbosacral region. The belt portion has a left and right portions and a rear portion that extends upwardly from a cutout of the rear portion of the compression pants and is attached fixedly thereto. The rear portion of the belt portion has a pack support structure for receiving a hot or cold pack so as to maintain hot or cold therapy on the wearer's back. Slots in the belt portion may accommodate vertically extending inserts of rigid plastic or spiral metallic to reinforce the belt portion over the lumbosacral region of the wearer. A front core support structure provides abdominal support in combination with the back support that supports the entire core of the wearer's body. The garment can be changed to an immobilizing brace device by inserting optional rigid inserts.

Abstract: Therapeutics and methods of treatment to repair, preserve and grow cartilage are presented. In addition, systems and methods for delivering a therapeutic to a hard to reach anatomical area, such as, for example, the BCI, are presented. A cannulated delivery device provided with a cutting tip, cutting flutes and threads on its distal end is disclosed, as well as therapies for joint and cartilage repair, preservation and generation using it. Alternatively, for disc repair, a “PIARES” device for Percutaneous Intradiscal Annular Repair introduces therapeutics intradiscally. The device may have two-needles; a first cannula/needle with a finger grip, and a longer inner needle to penetrate through the outer needle into the disc, and introduce therapeutics via a syringe. When provided with a septum at the inner needle's proximal end, the PIARES device is a completely closed system; using it minimizes trauma.

Abstract: A device may include a first locking mechanism configured to connect a first end of the device to a needle, a second locking mechanism configured to connect a second end of the device to a syringe, a pressure transducer, a microprocessor and a light emitting diode. The pressure transducer may be configured to measure a first pressure at a first time and a second pressure at a second time. The microprocessor may be configured to receive the first pressure and the second pressure from the pressure transducer, determine a pressure difference between the first pressure and the second pressure, and determine a time difference between the first time and the second time. The light emitting diode may be configured to signal when the needle is properly situated based on the pressure difference and the time difference.

Abstract: A one-piece back support apparatus comprises a belt portion being configured to provide back and abdominal support encircling a wearer's waist and a compression pants portion. The belt portion has a front portion, a back portion, a top portion, a bottom portion and an inner surface. The compression pants portion secured to the belt is configured to provide support for the wearer's pelvis, legs, and groin area. The inner surface of the belt has one or more pack support portions with slots for receiving one or more gel packs so as to maintain contact between the gel packs and the wearer's back. Slots in the belt portion may accommodate vertically extending inserts of rigid plastic to reinforce the belt portion over the lumbar region of the wearer.

Abstract: A device may include a first locking mechanism configured to connect a first end of the device to a needle, a second locking mechanism configured to connect a second end of the device to a syringe, a pressure transducer, a microprocessor and a light emitting diode. The pressure transducer may be configured to measure a first pressure at a first time and a second pressure at a second time. The microprocessor may be configured to receive the first pressure and the second pressure from the pressure transducer, determine a pressure difference between the first pressure and the second pressure, and determine a time difference between the first time and the second time. The light emitting diode may be configured to signal when the needle is properly situated based on the pressure difference and the time difference.

Abstract: A one-piece back support apparatus comprises a belt portion being configured to provide back and abdominal support encircling a wearer's waist and a compression pants portion. The belt portion has a front portion, a back portion, a top portion, a bottom portion and an inner surface. The compression pants portion secured to the belt is configured to provide support for the wearer's pelvis, legs, and groin area. The inner surface of the belt has one or more pack support portions with slots for receiving one or more gel packs so as to maintain contact between the gel packs and the wearer's back. Slots in the belt portion may accommodate vertically extending inserts of rigid plastic to reinforce the belt portion over the lumbar region of the wearer.

Abstract: A composition for the relief of pain includes comprising a transducer, a fibrinolytic, at least one of a pain relief agent or an anti-inflammatory agent. The pain relief agent can be capsaicin and the fibrinolytic can be bromelain. The composition can also include at least one of a cooling component, a circulation increasing component, a joint or muscle soothing component and a muscle membrane stabilizer. the cooling agent fcan be menthol. A cream composition can include at least one cetyl esterified fatty acid. A cream can be made by combining the oil with a cream base. Suitable compositions include creams, gels, salves, sprays, powder, balms, liniment, ointments, and transdermal patches A system for pain relief that includes the oil and the cream, or a kit containing a container of the oil and a container of the cream.