Patents by Inventor Vijayalakshmi Mookambeswaran Arunachalam

Vijayalakshmi Mookambeswaran Arunachalam has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for producing recombinant factor VIII chains from non-filamentous fungi, their functional reconstitution and applications thereof
    Patent number: 9708387
    Abstract: A process of producing heavy chain peptide and/or light chain peptide of recombinant Factor VIII protein includes using the Pichia pastoris expression system. A process of producing a functional recombinant Factor VIII protein by reconstituting the Heavy chain and Light chain produced using said Pichia pastoris expression system. The said functional recombinant Factor VIII protein shows improved activity and therefore is used in the management of haemophilia.
    Type: Grant
    Filed: September 11, 2013
    Date of Patent: July 18, 2017
    Assignee: CENTRE FOR BIOSEPARATION TECHNOLOGY-VIT
    Inventors: Vijayalakshmi Mookambeswaran Arunachalam, Vignesh Narasimhan Janakiraman, Krishnan Venkataraman, Sudheer Reddy Aswatha Reddy, Satheeshkumar Padikkara Kutty, Sukesh Chandran Nair, Alok Srivastava
  • Dendrimers, conjugates and methods thereof
    Patent number: 9700632
    Abstract: The present disclosure relates to dendrimers composed of a hetero-bifunctional moiety and an aromatic heterocycle and to methods of synthesizing said dendrimers. The present disclosure also relates to dendrimer-bioactive molecule conjugates, the process of synthesizing the conjugates and pharmaceutical compositions comprising said conjugates. The dendrimer in the conjugates acts as a carrier and significantly increases the therapeutic efficacy of the bioactive molecule.
    Type: Grant
    Filed: September 13, 2013
    Date of Patent: July 11, 2017
    Assignee: CENTRE FOR BIOSEPERATION TECHNOLOGY-VIT
    Inventors: Vijayalakshmi Mookambeswaran Arunachalam, Jisha John, Yves Marie Daniel Gnanou, Vijayakrishna Kari
  • Double Mutant Coagulation Factor VIII and Methods Thereof
    Publication number: 20150337028
    Abstract: A double mutant B-domain deleted Factor VIII gene having mutations at Phe309Ser and Asp519Val, respectively, is disclosed for use in the field of haemophilia therapeutics. The disclosure a double mutant B-domain deleted Factor VIII protein having mutations at Phe309Ser and Asp519Val respectively, is also disclosed, as well as methods of producing the same. The B-domain deleted Factor VIII protein having mutations at Phe309Ser and Asp519Val shows enhanced activity and stability and therefore is used in the management of haemophilia.
    Type: Application
    Filed: September 12, 2013
    Publication date: November 26, 2015
    Inventors: Vijayalakshmi Mookambeswaran ARUNACHALAM, Bilgimol Chuvappumkal JOSEPH, Satheeshkumar Padikkara KUTTY, Sukesh Chandran NAIR, Alok SRIVASTAVA
  • Dendrimers, Conjugates and Methods Thereof
    Publication number: 20150238623
    Abstract: The present disclosure relates to dendrimers composed of a hetero-bifunctional moiety and an aromatic heterocycle and to methods of synthesizing said dendrimers. The present disclosure also relates to dendrimer-bioactive molecule conjugates, the process of synthesizing the conjugates and pharmaceutical compositions comprising said conjugates. The dendrimer in the conjugates acts as a carrier and significantly increases the therapeutic efficacy of the bioactive molecule.
    Type: Application
    Filed: September 13, 2013
    Publication date: August 27, 2015
    Inventors: Vijayalakshmi Mookambeswaran Arunachalam, Jisha John, Yves Marie Daniel Gnanou, Vijayakrishna Kari
  • Methods for Producing Recombinant Factor VIII Chains from Non-Filamentous Fungi, Their Functional Reconstitution and Applications Thereof
    Publication number: 20150225472
    Abstract: A process of producing heavy chain peptide and/or light chain peptide of recombinant Factor VIII protein includes using the Pichia pastoris expression system. A process of producing a functional recombinant Factor VIII protein by reconstituting the Heavy chain and Light chain produced using said Pichia pastoris expression system. The said functional recombinant Factor VIII protein shows improved activity and therefore is used in the management of haemophilia.
    Type: Application
    Filed: September 11, 2013
    Publication date: August 13, 2015
    Inventors: Vijayalakshmi Mookambeswaran Arunachalam, Vignesh Narasimhan Janakiraman, Krishnan Venkataraman, Sudheer Reddy Aswatha Reddy, Satheeshkumar Padikkara Kutty, Sukesh Chandran Nair, Alok Srivastava