Patents by Inventor Vijaykumar Baragi

Vijaykumar Baragi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 6284513
    Abstract: A process for the production of the catalytic domain, without propeptide, of a matrix metalloproteinase is described which comprises culturing transformed host cells carrying a DNA sequence encoding the catalytic domain as well as a method for screening for inhibitors of a matrix metalloproteinase; a method for determining the 3-dimensional structure of the catalytic domain of a matrix metalloproteinase; and pharmaceutical compositions of human stromelysin catalytic domain protein which are useful in treating herniated vertebral discs, dermal ulcers, modifying scar tissue formation, and joint diseases.
    Type: Grant
    Filed: July 27, 1994
    Date of Patent: September 4, 2001
    Assignee: Warner-Lambert Company
    Inventors: Qi-Zhuang Ye, Linda Lea Johnson, Donald John Hupe, Vijaykumar Baragi
  • Patent number: 6211209
    Abstract: The present invention provides a method of inhibiting connective tissue degradation that comprises administering to a patient having a condition in which connective tissue is degraded a therapeutically effective amount of a compound having the formula where R1, R2, R3, and R4 are independently hydrogen, hydroxy, halo, amino, nitro, C1-C6 alkyl, C3-C6 cycloalkyl, C1-C6 alkoxy, CF3, CN, S(O)n—, R6 and R7 are independently hydrogen, C1-C6 alkyl, or acyl; n is 0 to 2; R8 is hydrogen or C1-C6 alkyl; W is S or O; Z is C1-C6 alkyl, C1-C6 alkoxy, or NR9R10; R9 and R10 are independently hydrogen or C1-C6 alkyl; and R5 is where Y is hydroxy, thiol, amino, or NHCN; X is sulfur or oxygen; and Q is sulfur, oxygen, NH, or NCN, and the pharmaceutically acceptable salts and prodrugs thereof.
    Type: Grant
    Filed: August 6, 1998
    Date of Patent: April 3, 2001
    Assignee: Warner-Lambert Company
    Inventors: Vijaykumar Baragi, Diane Harris Boschelli, David Thomas Connor, Richard Raymond Renkiewicz, Howard Glenn Welgus
  • Patent number: 5703119
    Abstract: The manufacture and use of compounds of the formula ##STR1## wherein Y is O or S, R.sub.1 is hydrogen or alkyl, and R.sub.2, R.sub.3, R.sub.4 and R.sub.5 are hydrogen or various substituent groups, and pharmaceutically acceptable acid addition salts thereof. The compounds have activity as inhibitors of the IL-I or other agonist-induced proteoglycan degradation in bovine nasal cartilage and pharmaceutical compositions containing such compounds are described to treat conditions advantageously affected by such inhibition including arthritis.
    Type: Grant
    Filed: May 24, 1995
    Date of Patent: December 30, 1997
    Assignee: Warner-Lambert Company
    Inventors: Vijaykumar Baragi, Diane Harris Boschelli, David Thomas Connor, Richard Raymond Renkiewicz
  • Patent number: 5358964
    Abstract: The manufacture and use of compounds of the formula ##STR1## wherein Y is O or S, R.sub.1 is hydrogen or alkyl, and R.sub.2, R.sub.3, R.sub.4 and R.sub.5 are hydrogen or various substituent groups, and pharmaceutically acceptable acid addition salts thereof. The compounds have activity as inhibitors of the IL-I or other agonist-induced proteoglycan degradation in bovine nasal cartilage and pharmaceutical compositions containing such compounds are described to treat conditions advantageously affected by such inhibition including arthritis.
    Type: Grant
    Filed: July 26, 1993
    Date of Patent: October 25, 1994
    Assignee: Warner-Lambert Company
    Inventors: Vijaykumar Baragi, Diane H. Boschelli, David T. Connor, Richard R. Renkiewicz