Abstract: Methods, apparatuses, systems, and computer program products are disclosed for determining a flight plan. An example method includes determining one or more potential flight plans from an originating location to a destination location, each potential flight plan comprising a different combination of one or more flight plan segments forming a potential flight plan from the originating location to the destination location. The method further includes calculating a projected cost for each of the one or more potential flight plans wherein the projected cost is based at least in part on dynamic cost data, dynamic navigation data, or a combination thereof. The method further includes determining an optimal flight plan from among the one or more potential flight plans, the optimal flight plan having a lowest aggregate cost of the calculated projected costs associated with each of the one or more potential flight plans.

Abstract: Methods, apparatuses, systems, and computer program products are disclosed for determining a flight plan. An example method includes determining one or more potential flight plans from an originating location to a destination location, each potential flight plan comprising a different combination of one or more flight plan segments forming a potential flight plan from the originating location to the destination location. The method further includes calculating a projected cost for each of the one or more potential flight plans wherein the projected cost is based at least in part on dynamic cost data, dynamic navigation data, or a combination thereof. The method further includes determining an optimal flight plan from among the one or more potential flight plans, the optimal flight plan having a lowest aggregate cost of the calculated projected costs associated with each of the one or more potential flight plans.

Abstract: Novel compounds belonging to the class of oxazolidinones possessing potent antimycobacterial properties especially useful in the treatment of acid fast organisms such as Mycobacterium tuberculosis, Mycobacterium avium-intracellular complex, M. fortuitum and M. kansai. The compound and its pharmaceutically acceptable salts thereof act as antibacterial agents. Also disclosed is a method for inhibiting growth of mycobacterial cells as well as a method of treating mycobacterial conditions such as Mycobacterium tuberculosis, drug resistant Mycobacterium tuberculosis, Mycobacterium avium-intracellular complex, M. fortuitum and M. kansai, comprising administering an antimycobacterially effective amount of the said compound and/or pharmaceutically acceptable salts thereof. There is also disclosed a process for the manufacture of the said compound or its pharmaceutically acceptable salts.