Patents by Inventor Vijayvitthal Thippannachar Mathad

Vijayvitthal Thippannachar Mathad has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for the preparation of solifenacin and intermediate thereof
    Patent number: 8283470
    Abstract: A method for the preparation of solifenacin by reacting quinuclidin-3-ol and bis (aryl) carbonate to form (3R)-1-azabicyclo[2.2.2]oct-3-yl 4-aryl carbonate of formula (IVa); and treating (3R)-1-azabicyclo[2.2.2]oct-3-yl 4-aryl carbonate of formula (IVa) with (1S)-1-phenyl- 1,2,3,4-tetrahydroisoquinoline of formula (V) in an inert atmosphere to form a Solifenacin base, which is converted into its pharmaceutically acceptable salts. The invention also provides a compound, (3R)-1-azabicyclo[2.2.2]oct-3-yl 4-aryl carbonate of formula (IVa), which is used as an intermediate for the preparation of Solifenacin base and a process for the preparation thereof.
    Type: Grant
    Filed: August 31, 2009
    Date of Patent: October 9, 2012
    Assignee: Megafine Pharma(P) Ltd.
    Inventors: Vijayvitthal Thippannachar Mathad, Navnath Chintaman Niphade, Anil Chaturlal Mali, Kunal Madhav Jagtap, Bhushan Sudhakar Pandit, P. Raghvendra Kumar, Shashikant Baburao Landge
  • Method For The Preparation Of Cinacalcet And Intermediates And Impurities Thereof
    Publication number: 20110319663
    Abstract: A method for the preparation of Cinacalcet is disclosed comprising treating (R)-1-naphthyl ethylamine with an aromatic aldehyde to form (1R)-1-(2-naphthyl)-N-(aryl methylene)ethanamine derivative of Formula (IV), which is further treated with 1-(3-halopropyl)-3-(trifluoromethyl)benzene of Formula (V) to obtain an iminium salt of Formula (VI), followed by hydrolysis to obtain Cinacalcet free base.
    Type: Application
    Filed: September 6, 2011
    Publication date: December 29, 2011
    Applicant: Amneal Pharmaceuticals, LLC
    Inventors: Vijayvitthal Thippannachar Mathad, Navnath Chintaman Niphade, Gorakshanath Balasaheb Shinde, Sharad Subhash Ippar, Shrikant Prataprao Deshmukh, Ragavendra Kumar Panchangam
  • METHOD FOR THE PREPARATION OF SOLIFENACIN AND INTERMEDIATE THEREOF
    Publication number: 20110319621
    Abstract: A method for the preparation of solifenacin by reacting quinuclidin-3-ol and bis(aryl) carbonate to form (3R)-1-azabicyclo[2.2.2]oct-3-yl 4-aryl carbonate of formula (IVa); and treating (3R)-1-azabicyclo[2.2.2]oct-3-yl 4-aryl carbonate of formula (IVa) with (1S)-1-phenyl-1,2,3,4-tetrahydroisoquinoline of formula (V) in an inert atmosphere to form a Solifenacin base, which is converted into its pharmaceutically acceptable salts. The invention also provides a compound, (3R)-1-azabicyclo[2.2.2]oct-3-yl 4-aryl carbonate of formula (IVa), which is used as an intermediate for the preparation of Solifenacin base and a process for the preparation thereof.
    Type: Application
    Filed: August 31, 2009
    Publication date: December 29, 2011
    Applicant: Megafine Pharma(P) Ltd.
    Inventor: Vijayvitthal Thippannachar Mathad