Patents by Inventor Vikas Prabhakar
Vikas Prabhakar has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11151120Abstract: There are provided systems and methods for determining data validity during data processing for multiple processing stacks. During processing requests with a service provider, each request may go through a data flow that invokes multiple processing stacks, where the data is transmitted over a network to different data processing nodes. For example, a distributed computing architecture may invoke multiple disparate nodes to process data, which may become corrupted during data transmission and processing. To ensure data validity, a framework may be provided that provided data translators for each processing stack to covert data handled in a processing format for that stack into a base data format utilized by the framework. The framework may utilize checksums or other hash values of the data in the base data format to determine if the data has been altered at different processing nodes or stacks.Type: GrantFiled: March 29, 2019Date of Patent: October 19, 2021Assignee: PAYPAL, INC.Inventors: Shanmugasundaram Alagumuthu, Vikas Prabhakar, Ashish Srivastava
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Patent number: 11093310Abstract: Systems, methods, and computer program products for identifying a data pattern change anomaly uses a distributing computing environment that processes thousands of different data flows are provided. Numerous data flows are collected from the application computing environment over a configurable time period. The flows are aggregated into aggregated data according to at least one attribute from the flows and without losing information included in the flows. Historical data that includes aggregated data from multiple flows that occurred prior to a time during which the numerous data flows were collected is provided from a distributed disk storage. An anomaly that indicates change in data patterns in the flows is identified by comparing the aggregated data to the historical data using one or more models that are tailored to the numerous flows. An alert that includes an anomaly and a reason for an anomaly is transmitted and recorded in the system.Type: GrantFiled: December 31, 2018Date of Patent: August 17, 2021Assignee: PayPal, Inc.Inventors: Vikas Prabhakar, Min Huang, Shanmugasundaram Alagumuthu, Libao Cao
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Publication number: 20200311049Abstract: There are provided systems and methods for determining data validity during data processing for multiple processing stacks. During processing requests with a service provider, each request may go through a data flow that invokes multiple processing stacks, where the data is transmitted over a network to different data processing nodes. For example, a distributed computing architecture may invoke multiple disparate nodes to process data, which may become corrupted during data transmission and processing. To ensure data validity, a framework may be provided that provided data translators for each processing stack to covert data handled in a processing format for that stack into a base data format utilized by the framework. The framework may utilize checksums or other hash values of the data in the base data format to determine if the data has been altered at different processing nodes or stacks.Type: ApplicationFiled: March 29, 2019Publication date: October 1, 2020Inventors: Shanmugasundaram Alagumuthu, Vikas Prabhakar, Ashish Srivastava
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Publication number: 20200210260Abstract: Systems, methods, and computer program products for identifying a data pattern change anomaly uses a distributing computing environment that processes thousands of different data flows are provided. Numerous data flows are collected from the application computing environment over a configurable time period. The flows are aggregated into aggregated data according to at least one attribute from the flows and without losing information included in the flows. Historical data that includes aggregated data from multiple flows that occurred prior to a time during which the numerous data flows were collected is provided from a distributed disk storage. An anomaly that indicates change in data patterns in the flows is identified by comparing the aggregated data to the historical data using one or more models that are tailored to the numerous flows. An alert that includes an anomaly and a reason for an anomaly is transmitted and recorded in the system.Type: ApplicationFiled: December 31, 2018Publication date: July 2, 2020Inventors: Vikas Prabhakar, Min Huang, Shanmugasundaram Alagumuthu, Libao Cao
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Patent number: 8338119Abstract: The invention relates to chondroitinase ABC I and uses thereof. In particular, the invention relates to recombinant and modified chondroitinase ABC I, their production and their uses. The chondroitinase ABC I enzymes of the invention are useful for a variety of purposes, including degrading and analyzing polysaccharides such as glycosaminoglycans (GAGs). These GAGs can include chondroitin sulfate, dermatan sulfate, unsulfated chondroitin and hyaluronan. The chondroitinase ABC I enzymes can also be used in therapeutic methods such as promoting nerve regeneration, promoting stroke recovery, treating spinal cord injury, treating epithelial disease, treating infections and treating cancer.Type: GrantFiled: December 13, 2006Date of Patent: December 25, 2012Assignee: Massachusetts Institute of TechnologyInventors: Vikas Prabhakar, Ishan Capila, Rahul Raman, Carlos Bosques, Kevin Pojasek, Ram Sasisekharan
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Publication number: 20120135049Abstract: Methods for producing tissue engineered constructs and engineered native tissues include producing a tissue engineered construct by growing cells in vitro on a substrate and then decellularizing the construct to produce a decellularized construct consisting largely of extracellular matrix components. The construct can be used immediately or stored until needed. The decellularized construct can be used for further tissue engineering, which may include seeding the construct with cells obtained from the intended recipient of the construct. During any of the growth phases required for production of the construct, the developing construct may be subjected to various tissue engineering steps such as application of mechanical stimuli including pulsatile forces.Type: ApplicationFiled: December 28, 2011Publication date: May 31, 2012Applicant: DUKE UNIVERSITYInventors: Shannon MITCHELL, Jennifer KOH, Vikas PRABHAKAR, Laura NIKLASON
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Patent number: 7662604Abstract: The invention relates to chondroitinase ABC I and uses thereof. In particular, the invention relates to recombinant and modified chondroitinase ABC I, their production and their uses. The chondroitinase ABC I enzymes of the invention are useful for a variety of purposes, including degrading and analyzing polysaccharides such as glycosaminoglycans (GAGs). These GAGs can include chondroitin sulfate, dermatan sulfate, unsulfated chondroitin and hyaluronan. The chondroitinase ABC I enzymes can also be used in therapeutic methods such as promoting nerve regeneration, promoting stroke recovery, treating spinal cord injury, treating epithelial disease, treating infections and treating cancer.Type: GrantFiled: December 13, 2006Date of Patent: February 16, 2010Assignee: Massachusetts Institute of TechnologyInventors: Vikas Prabhakar, Ishan Capila, Rahul Raman, Carlos Bosques, Kevin Pojasek, Ram Sasisekharan
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Patent number: 7592152Abstract: The invention relates to chondroitinase ABC I and uses thereof. In particular, the invention relates to recombinant and modified chondroitinase ABC I, their production and their uses. The chondroitinase ABC I enzymes of the invention are useful for a variety of purposes, including degrading and analyzing polysaccharides such as glycosaminoglycans (GAGs). These GAGs can include chondroitin sulfate, dermatan sulfate, unsulfated chondroitin and hyaluronan. The chondroitinase ABC I enzymes can also be used in therapeutic methods such as promoting nerve regeneration, promoting stroke recovery, treating spinal cord injury, treating epithelial disease, treating infections and treating cancer.Type: GrantFiled: December 13, 2006Date of Patent: September 22, 2009Assignee: Massachusetts Institute of TechnologyInventors: Vikas Prabhakar, Ishan Capila, Rahul Raman, Carlos Bosques, Kevin Pojasek, Ram Sasisekharan
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Patent number: 7553950Abstract: The invention relates to chondroitinase ABC I and uses thereof. In particular, the invention relates to recombinant and modified chondroitinase ABC I, their production and their uses. The chondroitinase ABC I enzymes of the invention are useful for a variety of purposes, including degrading and analyzing polysaccharides such as glycosaminoglycans (GAGs). These GAGs can include chondroitin sulfate, dermatan sulfate, unsulfated chondroitin and hyaluronan. The chondroitinase ABC I enzymes can also be used in therapeutic methods such as promoting nerve regeneration, promoting stroke recovery, treating spinal cord injury, treating epithelial disease, treating infections and treating cancer.Type: GrantFiled: December 13, 2006Date of Patent: June 30, 2009Assignee: Massachusetts Institute of TechnologyInventors: Vikas Prabhakar, Ishan Capila, Rahul Raman, Carlos Bosques, Kevin Pojasek, Ram Sasisekharan
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Patent number: 7507570Abstract: The invention relates to chondroitinase ABC I and uses thereof. In particular, the invention relates to recombinant and modified chondroitinase ABC I, their production and their uses. The chondroitinase ABC I enzymes of the invention are useful for a variety of purposes, including degrading and analyzing polysaccharides such as glycosaminoglycans (GAGs). These GAGs can include chondroitin sulfate, dermatan sulfate, unsulfated chondroitin and hyaluronan. The chondroitinase ABC I enzymes can also be used in therapeutic methods such as promoting nerve regeneration, promoting stroke recovery, treating spinal cord injury, treating epithelial disease, treating infections and treating cancer.Type: GrantFiled: March 10, 2005Date of Patent: March 24, 2009Assignee: Massachusetts Institute of TechnologyInventors: Vikas Prabhakar, Ishan Capila, Rahul Raman, Carlos Bosques, Kevin Pojasek, Ram Sasisekharan
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Publication number: 20080248080Abstract: New methods for producing tissue engineered constructs and engineered native tissues are disclosed. The methods include producing a tissue engineered construct by growing cells in vitro on a substrate and then decellularizing the construct to produce a decellularized construct consisting largely of extracellular matrix components. The construct can be used immediately or stored until needed. The decellularized construct can be used for further tissue engineering, which may include seeding the construct with cells obtained from the intended recipient of the construct. During any of the growth phases required for production of the construct, the developing construct may be subjected to various tissue engineering steps such as application of mechanical stimuli including pulsatile forces. The methods also include producing an engineered native tissue by harvesting tissue from an animal or human, performing one or more tissue engineering steps on the tissue, and subjecting the tissue to decellularization.Type: ApplicationFiled: May 21, 2008Publication date: October 9, 2008Applicant: Duke UniversityInventors: Shannon Mitchell, Jennifer Koh, Vikas Prabhakar, Laura Niklason
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Publication number: 20070224670Abstract: The invention relates to chondroitinase ABC I and uses thereof. In particular, the invention relates to recombinant and modified chondroitinase ABC I, their production and their uses. The chondroitinase ABC I enzymes of the invention are useful for a variety of purposes, including degrading and analyzing polysaccharides such as glycosaminoglycans (GAGs). These GAGs can include chondroitin sulfate, dermatan sulfate, unsulfated chondroitin and hyaluronan. The chondroitinase ABC I enzymes can also be used in therapeutic methods such as promoting nerve regeneration, promoting stroke recovery, treating spinal cord injury, treating epithelial disease, treating infections and treating cancer.Type: ApplicationFiled: December 13, 2006Publication date: September 27, 2007Applicant: Massachusetts Institute of TechnologyInventors: Vikas Prabhakar, Ishan Capila, Rahul Raman, Carlos Bosques, Kevin Pojasek, Ram Sasisekharan
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Publication number: 20070202563Abstract: The invention relates to chondroitinase ABC I and uses thereof. In particular, the invention relates to recombinant and modified chondroitinase ABC I, their production and their uses. The chondroitinase ABC I enzymes of the invention are useful for a variety of purposes, including degrading and analyzing polysaccharides such as glycosaminoglycans (GAGs). These GAGs can include chondroitin sulfate, dermatan sulfate, unsulfated chondroitin and hyaluronan. The chondroitinase ABC I enzymes can also be used in therapeutic methods such as promoting nerve regeneration, promoting stroke recovery, treating spinal cord injury, treating epithelial disease, treating infections and treating cancer.Type: ApplicationFiled: December 13, 2006Publication date: August 30, 2007Applicant: Massachusetts Institute of TechnologyInventors: Vikas Prabhakar, Ishan Capila, Rahul Raman, Carlos Bosques, Kevin Pojasek, Ram Sasisekharan
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Publication number: 20070148740Abstract: The invention relates to chondroitinase ABC I and uses thereof. In particular, the invention relates to recombinant and modified chondroitinase ABC I, their production and their uses. The chondroitinase ABC I enzymes of the invention are useful for a variety of purposes, including degrading and analyzing polysaccharides such as glycosaminoglycans (GAGs). These GAGs can include chondroitin sulfate, dermatan sulfate, unsulfated chondroitin and hyaluronan. The chondroitinase ABC I enzymes can also be used in therapeutic methods such as promoting nerve regeneration, promoting stroke recovery, treating spinal cord injury, treating epithelial disease, treating infections and treating cancer.Type: ApplicationFiled: December 13, 2006Publication date: June 28, 2007Applicant: Massachusetts Institute of TechnologyInventors: Vikas Prabhakar, Ishan Capila, Rahul Raman, Carlos Bosques, Kevin Pojasek, Ram Sasisekharan
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Publication number: 20070148157Abstract: The invention relates to chondroitinase ABC I and uses thereof. In particular, the invention relates to recombinant and modified chondroitinase ABC I, their production and their uses. The chondroitinase ABC I enzymes of the invention are useful for a variety of purposes, including degrading and analyzing polysaccharides such as glycosaminoglycans (GAGs). These GAGs can include chondroitin sulfate, dermatan sulfate, unsulfated chondroitin and hyaluronan. The chondroitinase ABC I enzymes can also be used in therapeutic methods such as promoting nerve regeneration, promoting stroke recovery, treating spinal cord injury, treating epithelial disease, treating infections and treating cancer.Type: ApplicationFiled: December 13, 2006Publication date: June 28, 2007Applicant: Massachusetts Institute of TechnologyInventors: Vikas Prabhakar, Ishan Capila, Rahul Raman, Carlos Bosques, Kevin Pojasek, Ram Sasisekharan
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Publication number: 20060078959Abstract: The invention relates to chondroitinase ABC I and uses thereof. In particular, the invention relates to recombinant and modified chondroitinase ABC I, their production and their uses. The chondroitinase ABC I enzymes of the invention are useful for a variety of purposes, including degrading and analyzing polysaccharides such as glycosaminoglycans (GAGs). These GAGs can include chondroitin sulfate, dermatan sulfate, unsulfated chondroitin and hyaluronan. The chondroitinase ABC I enzymes can also be used in therapeutic methods such as promoting nerve regeneration, promoting stroke recovery, treating spinal cord injury, treating epithelial disease, treating infections and treating cancer.Type: ApplicationFiled: March 10, 2005Publication date: April 13, 2006Applicant: Massachusetts Institute of TechnologyInventors: Vikas Prabhakar, Ishan Capila, Rahul Raman, Carlos Bosques, Kevin Pojasek, Ram Sasisekharan
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Publication number: 20060073590Abstract: New methods for producing tissue engineered constructs and engineered native tissues are disclosed. The methods include producing a tissue engineered construct by growing cells in vitro on a substrate and then decellularizing the construct to produce a decellularized construct consisting largely of extracellular matrix components. The construct can be used immediately or stored until needed. The decellularized construct can be used for further tissue engineering, which may include seeding the construct with cells obtained from the intended recipient of the construct. During any of the growth phases required for production of the construct, the developing construct may be subjected to various tissue engineering steps such as application of mechanical stimuli including pulsatile forces. The methods also include producing an engineered native tissue by harvesting tissue from an animal or human, performing one or more tissue engineering steps on the tissue, and subjecting the tissue to decellularization.Type: ApplicationFiled: October 19, 2005Publication date: April 6, 2006Applicant: Duke UniversityInventors: Shannon Mitchell, Jennifer Koh, Vikas Prabhakar, Laura Niklason
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Patent number: 6962814Abstract: New methods for producing tissue engineered constructs and engineered native tissues are disclosed. The methods include producing a tissue engineered construct by growing cells in vitro on a substrate and then decellularizing the construct to produce a decellularized construct consisting largely of extracellular matrix components. The construct can be used immediately or stored until needed. The decellularized construct can be used for further tissue engineering, which may include seeding the construct with cells obtained from the intended recipient of the construct. During any of the growth phases required for production of the construct, the developing construct may be subjected to various tissue engineering steps such as application of mechanical stimuli including pulsatile forces. The methods also include producing an engineered native tissue by harvesting tissue from an animal or human, performing one or more tissue engineering steps on the tissue, and subjecting the tissue to decellularization.Type: GrantFiled: August 16, 2001Date of Patent: November 8, 2005Assignee: Duke UniversityInventors: Shannon Mitchell, Jennifer Koh, Vikas Prabhakar, Laura Niklason
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Publication number: 20020115208Abstract: New methods for producing tissue engineered constructs and engineered native tissues are disclosed. The methods include producing a tissue engineered construct by growing cells in vitro on a substrate and then decellularizing the construct to produce a decellularized construct consisting largely of extracellular matrix components. The construct can be used immediately or stored until needed. The decellularized construct can be used for further tissue engineering, which may include seeding the construct with cells obtained from the intended recipient of the construct. During any of the growth phases required for production of the construct, the developing construct may be subjected to various tissue engineering steps such as application of mechanical stimuli including pulsatile forces. The methods also include producing an engineered native tissue by harvesting tissue from an animal or human, performing one or more tissue engineering steps on the tissue, and subjecting the tissue to decellularization.Type: ApplicationFiled: August 16, 2001Publication date: August 22, 2002Inventors: Shannon Mitchell, Jennifer Koh, Vikas Prabhakar, Laura Niklason