Patents by Inventor Vikash Pal Singh CHAUHAN

Vikash Pal Singh CHAUHAN has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ENGINEERED NUCLEASES AND METHODS OF USE THEREOF
    Publication number: 20230265405
    Abstract: The present disclosure provides a method of editing a genome in a cell including exposing the cell to an engineered Cas nuclease comprising one or more mutations within the DNA binding cleft of the Cas nuclease, wherein exposure to the engineered Cas nuclease decreases, inhibits, or prevents non-homologous end joining (NHEJ) in the cell, and wherein exposure to the engineered Cas nuclease increases one or more homology-driven repair pathways within the cell. The mutant Cas nuclease is also disclosed herein.
    Type: Application
    Filed: December 21, 2022
    Publication date: August 24, 2023
    Inventors: VIKASH PAL SINGH CHAUHAN, PHILLIP A. SHARP, ROBERT LANGER
  • Polyacetal polymers, conjugates, particles and uses thereof
    Patent number: 11433136
    Abstract: Provided herein are polymers, pH-sensitive polymers and/or linkers; conjugates comprising said polymers and/or linkers, optionally, coupled to one or more agents and/or targeting moieties; and particles (e.g., nanoparticles comprising the aforesaid polymers, linkers and/or conjugates), which can be used to enhance the delivery and/or efficacy of one or more agents in a subject.
    Type: Grant
    Filed: December 16, 2016
    Date of Patent: September 6, 2022
    Assignees: The General Hospital Corporation, Massachusetts Institute of Technology, XTUIT Pharmaceuticals, Inc.
    Inventors: Peter Blume-Jensen, Donald E. Chickering, III, Paul W. Kopesky, Lawrence A. Reiter, Alan Crane, Robert S. Langer, Rong Tong, Rakesh K. Jain, Vikash Pal Singh Chauhan, Joao Incio, Dai Fukumura
  • POLYACETAL POLYMERS, CONJUGATES, PARTICLES AND USES THEREOF
    Publication number: 20180360978
    Abstract: Provided herein are polymers, pH-sensitive polymers and/or linkers; conjugates comprising said polymers and/or linkers, optionally, coupled to one or more agents and/or targeting moieties; and particles (e.g., nanoparticles comprising the aforesaid polymers, linkers and/or conjugates), which can be used to enhance the delivery and/or efficacy of one or more agents in a subject.
    Type: Application
    Filed: December 16, 2016
    Publication date: December 20, 2018
    Applicants: THE GENERAL HOSPITAL CORPORATION, MASSACHUSETTS INSTITUTE OF TECHNOLOGY, XTUIT PHARMACEUTICALS, INC.
    Inventors: Peter BLUME-JENSEN, Donald E. CHICKERING, III, Paul W. KOPESKY, Lawrence A. REITER, Alan CRANE, Robert S. LANGER, Rong TONG, Rakesh K. JAIN, Vikash Pal Singh CHAUHAN, Joao INCIO, Dai FUKUMURA