Abstract: Methods, computer systems, and apparatus, including computer programs encoded on computer storage media, for training a machine-learning model configured to generate a prediction and recommendation output from input data. The system obtains training data including a plurality of training examples, obtains context data, identifies one or more feature variables from the context data, constructs the machine-learning model based at least on the identified feature variables, generates feature variable training data by processing the training data based on the identified feature variables, and performs training and periodic update (if required) of the machine-learning model to generate model parameter data for the machine-learning model based at least on the generated feature variable training data.

Abstract: The present invention is directed to compounds and compositions comprising thereof. Further, methods of use such as for the treatment and prevention of a disorder associated with binding of IGF2BP1 to an RNA in a subject in need thereof are also provided.

Abstract: The invention relates to modified oligonucleotides, e.g., saRNAs useful in upregulating the expression of a target gene and therapeutic compositions comprising such oligonucleotides. Methods of using the oligonucleotides and the therapeutic compositions are also provided.

Abstract: A vascular access system configured for delivery of a tube or probe into a patient's vascular system, the vascular access system including a catheter adapter having a distal portion and a proximal portion, wherein a catheter extends from the distal portion and a septum assembly is housed within the proximal portion, and a connector assembly. The connector assembly includes a coupling interface configured to couple the connector assembly to the proximal portion of the catheter adapter, and a cannula. The cannula may be configured to extend through the septum assembly of the catheter adapter when the connector assembly is coupled to the proximal portion of the catheter adapter. The connector assembly also includes a proximal interface, wherein the proximal interface is configured for coupling to a blood draw device having an elongated core extending from a distal end thereof.

Abstract: Systems and techniques are generally described for semantically segmenting videos. In various examples, a selection of a first video may be received. A first query to segment the first video into segments related to a first category of content may be received. A first plurality of segments related to the first category may be determined. In some examples, time code data representing the first plurality of segments may be sent to a remote computing device, wherein a video player of the remote computing device is effective to play the first plurality of segments based at least in part on the time code data.

Abstract: A cross-wallet system generate a cross-platform key or a virtual account number for a first digital wallet provider to be used by the consumer when the consumer wishes to send payment to a second digital wallet provider with which the consumer does not possess an account. Moreover, the virtual account number, in one example, may only include a partial set of card number that does not include the typical set of card number. The virtual account number created by embodiments of the invention further enable security features that prevent fraud and protect the consumer's financial assets.

Abstract: The invention relates to a saRNAs useful in upregulating the expression of the SIRT1 gene and therapeutic compositions comprising the saRNA. Methods of using the saRNA and the therapeutic compositions are also provided.

Abstract: Disclosed is a system and a method for determining a brock score. A CT scan image may be resampled into a plurality of slices using a bilinear interpolation. A nodule may be detected on one or more of the plurality of slices. A region of interest associated with the nodule may be identified using an image processing technique. Further, a nodule segmentation may be performed to remove an area surrounding the region of interest. Subsequently, a plurality of characteristics associated with the nodule may be identified automatically using a deep learning model. Finally, a brock score for the patient may be determined based on the plurality of characteristics and demographic data of the patient.

Abstract: The present disclosure provides an optical fiber cable (200, 300) with a compressed core (206, 306) and manufacturing method thereof. The method includes bundling a plurality of optical transmission elements (202, 302) to form a core (206, 306) of the optical fiber cable (200, 300) and compressing the core (206, 306). The method further includes extruding a sheath (212, 312) around the compressed core (206, 306), wherein the core (206, 306) is compressed to a smaller diameter by a compression tool. The compression tool has a cylindrical cavity, wherein an internal diameter of the cylindrical cavity gradually decreases from a first end to a second end of the compression tool. The core enters from the first end of the compression tool with a diameter d and exits from the second end with a diameter d-?d, such that ?d/d is greater than or equal to 0.05.

Abstract: A catheter system may include a catheter assembly, which may include a catheter adapter and a catheter. The catheter system may include a needle assembly, a barrel, an introducer needle comprising a sharp distal tip, a needle hub coupled to the introducer needle and movably disposed within the barrel, and a spring disposed within the barrel. The catheter system may include a push button disposed in a locked position such that depression of the push button is inhibited. The push button may be configured to slide laterally or distally from the locked position to an unlocked position. When the push button is in the unlocked position and the barrel is spaced apart from the catheter adapter, the push button may be configured to depress. In response to depression of the push button, the spring may be configured to expand proximally and move the needle hub proximally within the barrel.

Abstract: Organic Electrochemical Transistors (OECTs) have the potential to enable fully flexible low-cost electronics. Combining OECTs with ionic electroactive polymers (IEAP) yields a highly sensitive bending sensors with respect to mechanical bending. In comparison the proposed sensor has a sensitivity that is several orders of magnitude larger than conventional electroactive polymers.

Abstract: A vascular access system for use with a blood draw or probe delivery device, the system including a catheter adapter having a proximal end portion and a distal end portion, wherein a catheter extends from the distal end portion of the catheter adapter, and an extension set. The extension set includes a stabilization platform, a catheter adapter interface, wherein the catheter adapter interface is configured to secure the proximal end portion of the catheter adapter, and a probe access portion. The probe access portion includes a needle free connector configured to receive a distal connector portion of the blood draw or probe delivery device, and the probe access portion is positioned in-line with the catheter adapter to provide a direct fluid path for a tube or probe of the blood draw or probe delivery device to be advanced through the probe access portion, the catheter adapter, and the catheter.

Abstract: In one embodiment, network node-to-node connectivity verification is performed in a network including data path processing of packets within a packet switching device. In one embodiment, an echo request connectivity test packet, emulating an echo request connectivity test packet received from a first connected network node, is inserted by the packet switching device prior in its data processing path prior to ingress processing performed for packets received from the first connected network node. A correspondingly received echo reply connectivity test packet is intercepted by the packet switching device during data path egress processing performed for packets to be forwarded to the first connected network node.

Abstract: An ionic liquid crystal elastomer composition includes a liquid crystal elastomer; and an ionic liquid.

Abstract: A method for event-driven dispute processing using distributed ledgers may include: receiving dispute information for a dispute involving a transaction; receiving, from a payment brand and at the distributed ledger, payment brand verification of the dispute information; receiving, from a merchant and at the distributed ledger, transaction details for the transaction; receiving, from the card issuer and at the distributed ledger, chargeback initiation; receiving, from the payment brand and at the distributed ledger, payment brand acceptance of the chargeback; receiving, from the merchant and at the distributed ledger, merchant acceptance of the chargeback; and receiving, from the card issuer and at the distributed ledger, notification of completion of the chargeback.

Abstract: A cross-wallet system generate a cross-platform key or a virtual account number for a first digital wallet provider to be used by the consumer when the consumer wishes to send payment to a second digital wallet provider with which the consumer does not possess an account. Moreover, the virtual account number, in one example, may only include a partial set of card number that does not include the typical set of card number. The virtual account number created by embodiments of the invention further enable security features that prevent fraud and protect the consumer's financial assets.

Abstract: In one embodiment, network node-to-node connectivity verification is performed in a network including data path processing of packets within a packet switching device. In one embodiment, an echo request connectivity test packet, emulating an echo request connectivity test packet received from a first connected network node, is inserted by the packet switching device prior in its data processing path prior to ingress processing performed for packets received from the first connected network node. A correspondingly received echo reply connectivity test packet is intercepted by the packet switching device during data path egress processing performed for packets to be forwarded to the first connected network node.

Abstract: A method of treating mild to moderate psoriasis in a patient administers an IL-23 specific antibody, e.g., guselkumab, at an initial dose and subsequent doses in order for the patient to respond to the antibody and meet one or more of the clinical endpoints.

Abstract: Techniques for pairing contacts and agents in a contact center system are disclosed. In one particular embodiment, the techniques may be realized as a method for pairing contacts and agents in a contact center system comprising: assigning, by at least one computer processor communicatively coupled to and configured to operate in the contact center system, a contact to an agent based on information associated with a prior interaction of the contact with the contact center system. The assigning of the contact to the agent may result in a less favorable outcome for the contact assigned to the agent and an increase in an overall performance of the contact center system.

Abstract: A crystalline sugar composite powder and methods for making the same. A crystalline sugar composite powder used as a sugar substitute ingredient. A crystalline sugar composite powder including crystalline sugar particles, and sugar composite particles, the sugar composite particles including cellulose fiber and a plurality of sugar crystals formed on a surface of the cellulose fiber. A process of preparing a crystalline sugar composite powder by a solvent inversion process as disclosed. A food or beverage including the crystalline sugar composite powder.