Patents by Inventor Vikram Ashok SARPE

Vikram Ashok SARPE has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Apramycin derivatives
    Patent number: 11485751
    Abstract: The invention relates to derivatives of apramycin-based aminoglycoside antibacterial drugs modified in positions C5 and/or C6 and O5 and/or O6. The modifications impart favourable properties regarding increased selectivity and retention of activity in the presence of resistance determinants of the AAC(3) class. The invention further relates to said compounds for use in the therapy of bacterial infection by systemic administration, especially in instances where the infection is caused by a pathogen comprising a resistance determinant of the AAC(3) class, in particular AAC(3)-IV.
    Type: Grant
    Filed: May 1, 2018
    Date of Patent: November 1, 2022
    Assignees: WAYNE STATE UNIVERSITY, UNIVERSITAT ZURICH
    Inventors: Erik C. Bottger, Sven N. Hobbie, Andrea Vasella, David Crich, Amr Sonousi, Takayuki Kato, Jonathan Quirke, Parasuraman Rajasekaran, Vikram Ashok Sarpe
  • APRAMYCIN DERIVATIVES
    Publication number: 20200062793
    Abstract: The invention relates to derivatives of apramycin-based aminoglycoside antibacterial drugs modified in positions C5 and/or C6 and O5 and/or O6. The modifications impart favourable properties regarding increased selectivity and retention of activity in the presence of resistance determinants of the AAC(3) class. The invention further relates to said compounds for use in the therapy of bacterial infection by systemic administration, especially in instances where the infection is caused by a pathogen comprising a resistance determinant of the AAC(3) class, in particular AAC(3)-IV.
    Type: Application
    Filed: May 1, 2018
    Publication date: February 27, 2020
    Applicants: WAYNE STATE UNIVERSITY, UNIVERSITAT ZURICH
    Inventors: Erik C. BOTTGER, Sven N. HOBBIE, Andrea VASELLA, David CRICH, Amr SONOUSI, Takayuki KATO, Jonathan QUIRKE, Parasuraman RAJASEKARAN, Vikram Ashok SARPE