Publication number: 20250221966
Abstract: The disclosure relates to compounds of Formula (I), which are RXFP1 receptor agonists, compositions containing them, and methods of using them, for example, in the treatment of heart failure, fibrotic diseases, and related diseases such as lung disease (e.g., idiopathic pulmonary fibrosis), kidney disease (e.g., chronic kidney disease), or hepatic disease (e.g., non-alcoholic steatohepatitis and portal hypertension).
Type:
Application
Filed:
October 28, 2022
Publication date:
July 10, 2025
Inventors:
Shun Su, Donna M. Bilder, Adam James Clarke, Heather Finlay, Todd J. Friends, Arvind Mathur, Michael C. Myers, R. Michael Lawrence, Jianqing Li, Donald J.P. Pinto, Michael J. Orwat, Kumar Balashanmuga Pabbisetty, Scott A. Shaw, Leon M. Smith, II, George O. Tora, Benjamin P. Vokits, Daniel O'Malley, Nicholas R. Wurtz, Vikram Bhogadi, Laxman Pasunoori, Pitani Veera Venkata Srinivas, Sreekantha Ratna Kumar, Hima Kiran Potturi, Subramanya Hegde