Abstract: Disclosed are methods, systems, cells and compositions directed to modeling a physiologic or pathologic process in an animal using a set of yeast genes analogous to a set of animal genes and augmenting the physiologic or pathologic process in the animal with predicted gene interactions based on the interactions between the set of yeast genes. Also disclosed are methods of screening for and using therapeutics for neurodegenerative proteinopathies.

Abstract: In some aspects, a cross-species platform useful for drug discovery in neurodegenerative diseases is described.

Abstract: Disclosed are methods, systems, cells and compositions directed to modeling a physiologic or pathologic process in an animal using a set of yeast genes analogous to a set of animal genes and augmenting the physiologic or pathologic process in the animal with predicted gene interactions based on the interactions between the set of yeast genes. Also disclosed are methods of screening for and using therapeutics for neurodegenerative proteinopathies.

Abstract: In some aspects, a cross-species platform useful for drug discovery in neurodegenerative diseases is described.

Abstract: In some aspects, a cross-species platform useful for drug discovery in neurodegenerative diseases is described.

Abstract: In one implementation, a conference bridge connects endpoints in a media conference. The various endpoints may have a wide range of video capabilities and audio capabilities. The video conference bridge learns the video capabilities of the endpoints and formulates a media plan based on these capabilities. The media plan instructs the endpoints on the types of media streams to produce. The video conference bridge may shape a media stream received from one of the endpoints by removing one or more layers. Accordingly, each endpoint decodes only the media streams that can be encoded by another endpoint and receives the best possible media stream from each endpoint.

Abstract: In one implementation, a conference bridge connects endpoints in a media conference. The various endpoints may have a wide range of video capabilities and audio capabilities. The video conference bridge learns the video capabilities of the endpoints and formulates a media plan based on these capabilities. The media plan instructs the endpoints on the types of media streams to produce. The video conference bridge may shape a media stream received from one of the endpoints by removing one or more layers. Accordingly, each endpoint decodes only the media streams that can be encoded by another endpoint and receives the best possible media stream from each endpoint.

Abstract: A Real-Time Protocol (RTP) source node of a network operates to send a first data packet of a first size to a destination node over a path of the network that includes a plurality of intermediate nodes, at least one of the intermediate nodes having a maximum transmission unit (MTU) size smaller than the first size such that fragmentation of the first data packet occurs. The destination node sends back to the source node a RTCP report that includes a number of fragments received and a largest minimum data packet size. In response, the source node sends subsequent data packets having a second size less than or equal to the largest data packet size of the fragments. It is emphasized that this abstract is provided to comply with the rules requiring an abstract that will allow a searcher or other reader to quickly ascertain the subject matter of the technical disclosure. It is submitted with the understanding that it will not be used to interpret or limit the scope or meaning of the claims.

Abstract: A Real-Time Protocol (RTP) source node of a network operates to send a first data packet of a first size to a destination node over a path of the network that includes a plurality of intermediate nodes, at least one of the intermediate nodes having a maximum transmission unit (MTU) size smaller than the first size such that fragmentation of the first data packet occurs. The destination node sends back to the source node a RTCP report that includes a number of fragments received and a largest minimum data packet size. In response, the source node sends subsequent data packets having a second size less than or equal to the largest data packet size of the fragments. It is emphasized that this abstract is provided to comply with the rules requiring an abstract that will allow a searcher or other reader to quickly ascertain the subject matter of the technical disclosure. It is submitted with the understanding that it will not be used to interpret or limit the scope or meaning of the claims. 37 CFR 1.72(b).