Patents by Inventor Vikram M. Paradkar

Vikram M. Paradkar has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Enzyme catalysis in organic solutions containing water
    Patent number: 6171813
    Abstract: A method is presented for catalyzing the conversion of substrate into product in an organic reaction solvent with an enzyme-surfactant ion pair. The enzyme-surfactant ion pair comprises the enzyme catalyzing the reaction and a surfactant capable of forming an ion pair with the enzyme. Water present in the organic solvent at a concentration of about 0.03% to about 2.5% is sufficient to enhance the rate of catalysis and stabilize the enzyme without substantially increasing the rate of hydrolysis when compared to the anhydrous enzyme.
    Type: Grant
    Filed: October 16, 1997
    Date of Patent: January 9, 2001
    Assignees: BioTechnology Research & Develop. Corp., The University of Iowa Research Foundation
    Inventors: Jonathan S. Dordick, Vikram M. Paradkar, Maria V. Sergeeva
  • Enzyme-surfactant ion-pair complex catalyzed reactions in organic solvents
    Patent number: 5719039
    Abstract: Organic enzyme solutions comprise an ion pair complex of an enzyme and a surfactant, and an organic solvent in which the enzyme-surfactant ion pair is dissolved. The solution has catalytic activity at least an order of magnitude greater than a suspension of an equal amount of the enzyme and organic solvent without ion pair complexes. The enzyme is preferably a hydrolase with an acyl transferase activity and the surfactant is Aerosol OT (sodium bis(2-ethylhexyl) sulfosuccinate) at low concentrations.
    Type: Grant
    Filed: June 1, 1995
    Date of Patent: February 17, 1998
    Assignees: University of Iowa Research Foundation, Biotechnology Research & Development Corp.
    Inventors: Jonathan S. Dordick, Vikram M. Paradkar