Abstract: This invention provides a system and method that employs multiple measurements of various, relevant tissue states of a patient to detect and predict OH and similar conditions. These multi anatomic measurements are transformed by a multivariate algorithm to outputs that convey the diagnostic and prognostic risk of the disease of interest. This novel, multiple-measurement technique avoids use of a single measurement, which is generally unlikely to adequately extract sufficient information to drive a clinically useful test in the setting of complex system disease. The system and method herein thereby allows automated monitoring of currently stable patients who, are known or suspected to have OH and/or similar internal conditions on a substantially continuous basis.