Abstract: The present invention provides compounds of formula (I) and/or salt thereof and/or biologically active metabolite thereof and/or prodrug thereof and/or solvate thereof and/or hydrate thereof and/or polymorph thereof having affinity and selectivity for the gamma-aminobutyric acid A receptor subunit alpha 5 and act as GABAA ?5 negative allosteric modulators, thereby useful in the treatment or prevention of diseases related to the GABAA ?5 receptor, process for the preparation and intermediates of the preparation process thereof, pharmaceutical compositions comprising them alone or in combination with one or more other active ingredients and their use as medicaments.

Abstract: The present invention provides compounds of formula (I) and/or salt thereof and/or biologically active metabolite thereof and/or prodrug thereof and/or solvate thereof and/or hydrate thereof and/or polymorph thereof having affinity and selectivity for the gam-ma-aminobutyric acid A receptor subunit alpha 5 and act as GABAA ?5 negative allosteric modulators, thereby useful in the treatment or prevention of diseases related to the GABAA ?5 receptor, process for the preparation and intermediates of the preparation process thereof, pharmaceutical compositions comprising them alone or in combination with one or more other active ingredients and their use as medicaments.