Patents by Inventor Viktoras Frismantas

Viktoras Frismantas has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Bone marrow microfluidic devices and methods for preparing and using the same
    Patent number: 11845920
    Abstract: The present disclosure relates to a microfluidic devices and methods for culturing bone marrow cells. Aspects include methods of preparing microfluidic devices and culturing bone marrow cells with the microfluidic devices. In some aspects, a method includes providing a microfluidic device having an upper chamber, a lower chamber, and a porous membrane separating the upper chamber from the lower chamber. The method further includes seeding walls of the lower chamber and a bottom surface of the membrane with endothelial cells. The method further includes providing a matrix within the upper chamber. The matrix includes fibrin gel and bone marrow cells. The method further includes filling or perfusing the upper chamber with a media.
    Type: Grant
    Filed: March 26, 2018
    Date of Patent: December 19, 2023
    Assignees: President and Fellows of Harvard College, The General Hospital Corporation
    Inventors: David Benson Chou, Liliana S. Teixeira Moreira Leijten, Arianna Rech, Richard Novak, Donald E. Ingber, Yuka Milton, Viktoras Frismantas, Oren Levy
  • BONE MARROW MICROFLUIDIC DEVICES AND METHODS FOR PREPARING AND USING THE SAME
    Publication number: 20230357690
    Abstract: The present disclosure relates to a microfluidic devices and methods for culturing bone marrow cells. Aspects include methods of preparing microfluidic devices and culturing bone marrow cells with the microfluidic devices. In some aspects, a method includes providing a microfluidic device having an upper chamber, a lower chamber, and a porous membrane separating the upper chamber from the lower chamber. The method further includes seeding walls of the lower chamber and a bottom surface of the membrane with endothelial cells. The method further includes providing a matrix within the upper chamber. The matrix includes fibrin gel and bone marrow cells. The method further includes filling or perfusing the upper chamber with a media.
    Type: Application
    Filed: June 28, 2023
    Publication date: November 9, 2023
    Applicants: President and Fellows of Harvard College, The General Hospital Corporation
    Inventors: David Benson Chou, Liliana S. Teixeira Moreira Leijten, Arianna Rech, Richard Novak, Donald E. Ingber, Yuka Milton, Viktoras Frismantas, Oren Levy
  • BONE MARROW MICROFLUIDIC DEVICES AND METHODS FOR PREPARING AND USING THE SAME
    Publication number: 20200095525
    Abstract: The present disclosure relates to a microfluidic devices and methods for culturing bone marrow cells. Aspects include methods of preparing microfluidic devices and culturing bone marrow cells with the microfluidic devices. In some aspects, a method includes providing a microfluidic device having an upper chamber, a lower chamber, and a porous membrane separating the upper chamber from the lower chamber. The method further includes seeding walls of the lower chamber and a bottom surface of the membrane with endothelial cells. The method further includes providing a matrix within the upper chamber. The matrix includes fibrin gel and bone marrow cells. The method further includes filling or perfusing the upper chamber with a media.
    Type: Application
    Filed: March 26, 2018
    Publication date: March 26, 2020
    Applicants: President and Fellows of Harvard College, The General Hospital Corporation
    Inventors: David Benson Chou, Liliana S. Teixeira Moreira Leijten, Arianna Rech, Richard Novak, Donald E. Ingber, Yuka Milton, Viktoras Frismantas, Oren Levy