Patents by Inventor Vilas V. Likhite

Vilas V. Likhite has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Novel mutant strain of Listeria monocytogenes and its use in production of IgM antibodies and as an immunotherapeutic agent
    Patent number: 4816253
    Abstract: A novel mutant strain of Listeria monocytogenes, termed by me "Listeria monocytogenes akka", has been discovered which functions as a killed strain not only as an antigen resulting in the production of relatively large titers of IgM antibodies in host animals but also as an immunopotentiating agent when conjugated to a sensitising antigen, for example, living tumor cells and herpes simplex virus. The high molecular weight IgM antibodies are readily separated from serum and recovered without loss of appreciable activity. The IgM antibodies can be divided into five subunits of IgG antibodies, of lesser molecular weight, having the same specificity as the IgM immunoglobulins. When the sensitizing antigens conjugated with the Listeria monocytogenes strain of this invention are tumor cells, the conjugate acts as an immunotherapeutic agent effective in cancer immunotherapy.
    Type: Grant
    Filed: December 10, 1985
    Date of Patent: March 28, 1989
    Inventor: Vilas V. Likhite
  • Mutant strain of Listeria monocytogenes and its use in production of IgM antibodies and as an immunotherapeutic agent
    Patent number: 4567041
    Abstract: A novel mutant strain of Listeria monocytogenes has been discovered which functions as a killed strain not only as an antigen resulting in the production of relatively large titers of IgM antibodies in host animals but also as an immunopotentiating agent when conjugated to a sensitising antigen, for example, living tumor cells and herpes simplex virus. The high molecular weight IgM antibodies are readily separated from serum and recovered without loss of appreciable activity. The IgM antibodies can be divided into five subunits of IgG antibodies, of lesser molecular weight, having the same specificity as the IgM immunoglobulins. When the sensitizing antigens conjugated with the Listeria monocytogenes strain of this invention are tumor cells, the conjugate acts as an immunotherapeutic agent effective in cancer immunotherapy.
    Type: Grant
    Filed: August 2, 1983
    Date of Patent: January 28, 1986
    Inventor: Vilas V. Likhite
  • Antigen compounds
    Patent number: 4372945
    Abstract: Antigens are provided which induce relatively large titers of antibodies. These antigens, which may comprise certain strains of microorganisms or a plant extract, can be conjugated to a second antigen by means of an organic coupling agent. The primary antigens of the invention, when chemically coupled to a secondary antigen function as immunostimulant adjuvants. When tumor cells are the secondary antigens, a means for immunotherapeutic treatment of cancer is provided.
    Type: Grant
    Filed: August 3, 1981
    Date of Patent: February 8, 1983
    Inventor: Vilas V. Likhite
  • Antigens comprising immunostimulant adjuvants and their use in immunotherapy
    Patent number: 4285930
    Abstract: Antigens are provided which induce relatively large titers of antibodies. These antigens, which may comprise certain strains of microorganisms or a plant extract, can be conjugated to a second antigen by means of an organic coupling agent. The primary antigens of the invention, when chemically coupled to a secondary antigen function as immunostimulant adjuvants. When tumor cells are the secondary antigens, a means for immunotherapeutic treatment of cancer is provided.
    Type: Grant
    Filed: November 13, 1979
    Date of Patent: August 25, 1981
    Inventor: Vilas V. Likhite