Abstract: A dosage form contains a biologically active ingredient for treating or preventing a disease in the animal or human body, where the treatment or prevention requires release of 50% or more of the biologically active ingredient in the small intestine within the pH range from 3 to 5.5. The dosage form contains: a) a core, containing the biologically active ingredient; b) an intermediate coating layer (ICL) onto or above the core, containing an alkaline agent; and c) an enteric coating layer (ECL) onto or above the intermediate coating layer, containing an enteric polymer. The relation of the alkaline agent to the enteric polymer is 5 to 95% when calculated by the formula: quantity ? of ? alkaline ? agent ? in ? grams ? in ? the ? I ? C ? L × 100 ( quantity ? of ? alkaline ? agent ? in ? grams ? in ? the ? I ? C ? L + quantity ? of ? enteric ? polymer ? in ? grams ? in ? the ? E ? C ? L ) .

Abstract: Ayurvedic encapsulated gold nanoparticles, methods of fabrication and methods of treatment are provided. A method of fabrication includes mixing dried gooseberry product or mango peel product or phytochemical existent therein, into a liquid medium to form a reducing agent solution. Gold salts are mixed into the reducing agent solution. Reaction of the gold salts proceeds, in the absence of any other reducing agent, to form a nanoparticle solution of stabilized, biocompatible Ayurvedic encapsulated gold nanoparticles. An Ayurvedic medicine consists of a non-radioactive gold nanoparticle encapsulated with phytochemical existent in mango peal or gooseberry in a capsule with curcumin extract and gum Arabic.

Abstract: A dosage form contains a) a core, containing a biologically active ingredient, which is stable to a degree of at least 95% at a pH of 3 for 2 hours at 22° C.; b) an intermediate coating layer (ICL) onto or above the core, containing an alkaline agent; and c) an enteric coating layer (ECL) onto or above the intermediate coating layer, containing an enteric polymer. The relation in percent of the alkaline agent in the ICL to the enteric polymer in the ECL is 5 to 95% when calculated by the formula: quantity ? of ? alkaline ? agent ? in ? grams ? in ? the ? ICL × 100 ( quantity ? of ? alkaline ? agent ? in ? grams ? in ? the ? ICL + quantity ? of ? enteric ? polymer ? in ? grams ? in ? the ? ? ECL ) .

Abstract: A method may include allocating, based on a first load requirement of a first tenant, a first bin having a fixed capacity for handing the first load requirement of the first tenant. In response to the first load requirement of the first tenant exceeding a first threshold of the fixed capacity of the first bin, packing a second bin allocated to handle a second load requirement of a second tenant. The second bin may be packed by transferring, to the second bin, the first load requirement of the first tenant based on the transfer not exceeding the first threshold of the fixed capacity of the second bin. In response to the transfer exceeding the first threshold of the fixed capacity of the second bin, allocating a third bin to handle the first load requirement of the first tenant.

Abstract: A method may include identifying an identifier field included in a first datatype of a seed data sample associated with a source system. The identifier field may store a first value that enables a differentiation between different instances of the first datatype. A relationship field, which stores a second value that define a relationship between the first datatype and a second data type, may be identified. A synthetic data sample may be generated by populating the identifier field of the synthetic data sample with a synthetically generated value and the relationship field of the synthetic data sample with the second value. The synthetic data sample may be sent to a target system to enable a performance of a task at the target system. The synthetic data sample may supplement a volume and/or a diversity of the data that occurs organically at the source system.

Abstract: A process can be used for preparing a polymer coated hard-shell capsule, filled with a fill containing a biologically active ingredient. The hard-shell capsule contains a body and a cap, and in a closed state, the cap overlaps the body either in a pre-locked state or in a final-locked state. The material of the body and the cap contains an ethyl-, methyl-, or propyl-ether of cellulose, starch, or pullulan. The hard-shell capsule is coated with a coating layer that covers the hard-shell capsule in the pre-locked state. The coating layer contains one or more (meth)acrylate copolymers, where the coating layer is present in an amount of about 1 to 5.8 mg/cm2. The process involves providing the polymer-coated hard-shell capsule in the pre-locked state to a capsule-filling machine, separating the body and the cap, filling the body with the fill, and rejoining the body and the cap in the final-locked state.

Abstract: Improving load distribution and consistency is provided. A device intermediary to clients and servers can maintain bit values indicative of server availability stored in indices arranged in various levels. A lowest level comprises indices corresponding to a list of servers repeated multiple times. Each index in a higher level maps to a set of indices in a lower level. The device can receive a request from a client to access a server. The device can identify an index in a highest level. The device can determine a second index in the highest level that is after the index in the highest level and has a bit value indicating server availability. The device can identify an index in the lowest level mapping to the second index in the highest level. The device can select a server corresponding to the index in the lowest level.

Abstract: Improving distribution of traffic from clients to servers is provided. A device intermediary to a plurality of clients and a plurality of servers can receive a request from a client of the plurality of clients to access one of the plurality of servers. The device can determine a hash value based on at least a portion of the request received from the client. The device can identify an index of a plurality of indices listing the plurality of servers repeated a plurality of times in a deterministic shuffled order. The device can apply a cache array routing protocol (CARP) algorithm to a second plurality of servers listed in a subset of the plurality of indices around the index. The device can select a server from the second plurality of servers with a highest hash value based on the application of the CARP algorithm.

Abstract: Devices, systems, and methods for percussion therapy of a patient's torso area provide percussive force to release and/or dislodge mucous from respiratory airways of a human patient. Such devices, systems, and methods may include a torso covering for securing to a patient's torso, percussive devices coupled to the torso covering, and an attachment assembly for supporting the torso covering. The percussive devices may include a percussion frame, an electromechanically actuated percussor for controlled movement between end positions, and resilient members attached to opposite ends of the percussion frame for assisting controlled movement of the percussor. The devices, systems, and methods disclosed herein provide efficient and comfortable high-frequency percussive force to a patient's torso, reducing stress on the patient and improving patient experience.

Abstract: The present invention is related to a method of preparing a solid dosage form, comprising the steps of: a. preparing a lubricant consisting of at least one polyunsaturated fatty acid salt; b. adding the lubricant and ingredients for the solid dosage form to a mixer; c. optionally carrying out one or more of the following steps: granulation, drying and sizing, d. blending the contents of the mixer; and e. compressing or slugging the blended contents to produce a solid dosage form. Solid dosage forms prepared according to this method and the use of PUFA salts as lubricant in tableting applications for compression of solid components are further comprised by the present invention.

Abstract: The present invention is related to a method of preparing a solid dosage form, comprising the steps of: a) preparing a binder consisting of at least one polyunsaturated fatty acid salt; b) adding the binder and ingredients for the solid dosage form to a mixer; c) optionally carrying out one or more of the following steps: granulation, drying and sizing, d) blending the contents of the mixer; and e) compressing or slugging the blended contents to produce a solid dosage form wherein the binding parameter (BP) for the solid dosage form is at least 2 and is determined by: BP=H/C, wherein H is the tablet breaking force in Newton (N) and C is the compression force in kilo Newton (kN). Solid dosage forms prepared according to this method and the use of PUFA salts as binder in tableting applications for compression of solid components are further comprised by the present invention.

Abstract: A fast flexoelectro-optic switching device containing bimesogen-doped and polymer-stabilized vertical standing helix (PSVSH) in a cholesteric liquid crystal. The PSVSH device exhibits a response time of less than 0.7 millisecond, high contrast and negligible hysteresis which is suitable for applications including blur-free displays, field-sequential color displays and active optical elements.

Abstract: Devices, systems, and methods for percussion therapy of a patient's torso area provide percussive force to release and/or dislodge mucous from respiratory airways of a human patient. Such devices, systems, and methods may include a torso covering for securing to a patient's torso, percussive devices coupled to the torso covering, and an attachment assembly for supporting the torso covering. The percussive devices may include a percussion frame, an electromechanically actuated percussor for controlled movement between end positions, and resilient members attached to opposite ends of the percussion frame for assisting controlled movement of the percussor. The devices, systems, and methods disclosed herein provide efficient and comfortable high-frequency percussive force to a patient's torso, reducing stress on the patient and improving patient experience.

Abstract: A process can be used for preparing a polymer coated hard-shell capsule, filled with a fill containing a biologically active ingredient. The hard-shell capsule contains a body and a cap, and in a closed state, the cap overlaps the body in a pre-locked state or a final-locked state. The material of the body and cap contains an ethyl-, methyl-, or propyl-ether of cellulose, starch, or pullulan. The hard-shell capsule is coated with a coating layer, containing one or more anionic cellulose(s), ethyl cellulose, and/or one or more starches comprising at least 35% by weight of amylose, where the coating layer is present in an amount of about 1 to 5.8 mg/cm2. The process involves providing the polymer-coated hard-shell capsule in the pre-locked state to a capsule-filling machine, separating the body and the cap, filling the body with the fill, and rejoining the body and the cap in the final-locked state.

Abstract: Engine exhaust gas treatment article comprising a contoured honeycomb body (300) including a contoured outlet end face (316) are disclosed. Also disclosed are methods of manufacturing an engine exhaust gas treatment article.

Abstract: A respiratory device includes a blower having an inlet and an outlet, a patient interface, and a valve including a valve member that is rotatable through a first angular displacement in a first direction from a first position to a second position. The outlet of the blower is coupled to the patient interface so that positive pressure is provided to a patient's airway via the patient interface when the valve member is in the first position. The inlet of the blower is coupled to the patient interface so that negative pressure is provided to the patient's airway via the patient interface when the valve member is in the second position. The valve member is rotatably oscillated back and forth when the valve member is in the first position and when the valve member is in the second position so that oscillations in the positive pressure and negative pressure, respectively, are provided to the patient's airway.

Abstract: A respiratory device includes a blower having an inlet and an outlet, a patient interface, and a valve including a valve member that is rotatable through a first angular displacement in a first direction from a first position to a second position. The outlet of the blower is coupled to the patient interface so that positive pressure is provided to a patient's airway via the patient interface when the valve member is in the first position. The inlet of the blower is coupled to the patient interface so that negative pressure is provided to the patient's airway via the patient interface when the valve member is in the second position. The valve member is rotatably oscillated back and forth when the valve member is in the first position and when the valve member is in the second position so that oscillations in the positive pressure and negative pressure, respectively, are provided to the patient's airway.

Abstract: A respiratory device includes a blower having an inlet and an outlet, a patient interface, and a valve including a valve member that is rotatable through a first angular displacement in a first direction from a first position to a second position. The outlet of the blower is coupled to the patient interface so that positive pressure is provided to a patient's airway via the patient interface when the valve member is in the first position. The inlet of the blower is coupled to the patient interface so that negative pressure is provided to the patient's airway via the patient interface when the valve member is in the second position. The valve member is rotatably oscillated back and forth when the valve member is in the first position and when the valve member is in the second position so that oscillations in the positive pressure and negative pressure, respectively, are provided to the patient's airway.

Abstract: A fast flexoelectro-optic switching device containing bimesogen-doped and polymer-stabilized vertical standing helix (PSVSH) in a cholesteric liquid crystal. The PSVSH device exhibits a response time of less than 0.7 millisecond, high contrast and negligible hysteresis which is suitable for applications including blur-free displays, field-sequential color displays and active optical elements.