Abstract: Synuclein-gamma (SNCG) inhibitors are useful for inhibiting or treating angiogenesis, endometriosis and/or endometrial lesion growth. They also potentiate efficacy of other hormonal agents in treating angiogenesis, endometriosis and/or endometrial lesion growth.

Abstract: A computer-implemented method for modifying an original design of an integrated circuit in accordance with an engineering change order (ECO) design includes cloning complex logic gate having multiple logic functions with cloned logic gates in parallel with the corresponding complex logic gates in the original design and the ECO design and expanding each cloned logic gate to corresponding base functionality logic gates to provide an expanded original design and an expanded ECO design using the processor. The method also includes modifying at least a portion of the expanded original design to have a circuit topology that is the same as the expanded ECO design in order to have an input from the expanded original design to an output structure be the same as the input from the expanded ECO design to the output structure in response to an expanded original design input and an expanded ECO design input being non-equivalent.

Abstract: A method and system to identify a region of a design block of an integrated circuit for redesign are described. The method includes dividing the design block into grids, each of the grids including a corresponding number of logic elements. The method also includes filtering each of the grids based on a specified criteria, the filtering including determining a number (B) of the corresponding logic elements among a total number (A) of the logic elements in each grid that meet the specified criteria. The region is a set of two or more of the grids based on a result of the filtering.

Abstract: A computer-implemented method for modifying an original design of an integrated circuit in accordance with an engineering change order (ECO) design includes cloning complex logic gate having multiple logic functions with cloned logic gates in parallel with the corresponding complex logic gates in the original design and the ECO design and expanding each cloned logic gate to corresponding base functionality logic gates to provide an expanded original design and an expanded ECO design using the processor. The method also includes modifying at least a portion of the expanded original design to have a circuit topology that is the same as the expanded ECO design in order to have an input from the expanded original design to an output structure be the same as the input from the expanded ECO design to the output structure in response to an expanded original design input and an expanded ECO design input being non-equivalent.

Abstract: Synuclein-gamma (SNCG) inhibitors are useful for inhibiting or treating angiogenesis, endometriosis and/or endometrial lesion growth. They also potentiate efficacy of other hormonal agents in treating angiogenesis, endometriosis and/or endometrial lesion growth.

Abstract: A method and system to identify a region of a design block of an integrated circuit for redesign are described. The method includes dividing the design block into grids, each of the grids including a corresponding number of logic elements. The method also includes filtering each of the grids based on a specified criteria, the filtering including determining a number (B) of the corresponding logic elements among a total number (A) of the logic elements in each grid that meet the specified criteria. The region is a set of two or more of the grids based on a result of the filtering.

Abstract: A method and system to identify a region of a design block of an integrated circuit for redesign are described. The method includes dividing the design block into grids, each of the grids including a corresponding number of logic elements. The method also includes filtering each of the grids based on a specified criteria, the filtering including determining a number (B) of the corresponding logic elements among a total number (A) of the logic elements in each grid that meet the specified criteria. The region is a set of two or more of the grids based on a result of the filtering.

Abstract: A method and system to identify a region of a design block of an integrated circuit for redesign are described. The method includes dividing the design block into grids, each of the grids including a corresponding number of logic elements. The method also includes filtering each of the grids based on a specified criteria, the filtering including determining a number (B) of the corresponding logic elements among a total number (A) of the logic elements in each grid that meet the specified criteria. The region is a set of two or more of the grids based on a result of the filtering.

Abstract: Techniques for synthesized circuit design are described herein. The techniques include identifying a region of a synthesized logical circuit design, and un-mapping gates of the identified region. A logical resynthesis is performed on the unmapped gates based on a predetermined optimization for the identified region.

Abstract: Techniques for synthesized circuit design are described herein. The techniques include identifying a region of a synthesized logical circuit design, and un-mapping gates of the identified region. A logical resynthesis is performed on the unmapped gates based on a predetermined optimization for the identified region.

Abstract: A method and system to identify a region of a design block of an integrated circuit for redesign are described. The method includes dividing the design block into grids, each of the grids including a corresponding number of logic elements. The method also includes filtering each of the grids based on a specified criteria, the filtering including determining a number (B) of the corresponding logic elements among a total number (A) of the logic elements in each grid that meet the specified criteria. The region is a set of two or more of the grids based on a result of the filtering.

Abstract: A method and system to identify a region of a design block of an integrated circuit for redesign are described. The method includes dividing the design block into grids, each of the grids including a corresponding number of logic elements. The method also includes filtering each of the grids based on a specified criteria, the filtering including determining a number (B) of the corresponding logic elements among a total number (A) of the logic elements in each grid that meet the specified criteria. The region is a set of two or more of the grids based on a result of the filtering.

Abstract: Synuclein-gamma (SNCG) inhibitors are useful for inhibiting or treating angiogenesis, endometriosis and/or endometrial lesion growth. They also potentiate efficacy of other hormonal agents in treating angiogenesis, endometriosis and/or endometrial lesion growth.

Abstract: An apparatus for connecting multi-lumen conduits may include a conduit adapter and a conduit collar. The conduit adapter may include a housing, a bayonet connector, and a support member connecting the housing and the bayonet connector. The support member has an aperture that permits fluid communication through the support member. One end of the conduit collar is sized for insertion into the housing, and a second end is adapted to receive a first multi-lumen conduit. The housing also is adapted to receive a second multi-lumen conduit. The bayonet connector engages a primary lumen of the first multi-lumen conduit and the second multi-lumen conduit such that the primary lumen of the second multi-lumen conduit fluidly communicates with the primary lumen of the first multi-lumen conduit. The conduit adapter and the conduit collar are capable of 360 degree rotation relative to each other about a common axis.

Abstract: A class of compounds useful in pharmaceutical compositions and methods for treating or preventing cancer is described. The compounds' ability to inhibit RET kinase is quantified, i.e., their respective RET IC50 and EC50 values are described. One such compound, known as cyclobenzaprine and herein as SW-01, has been identified as RET-specific with an IC50 of 300 nM. SW-01 inhibits RET autophosphorylation and blocks the growth and transformation of thyroid cancer cell lines. It has been further tested in pancreatic cancer, breast cancer, and SCLC cell lines. The compounds show utility for inhibition of survival and proliferation of tumor cells.

Abstract: An apparatus for connecting multi-lumen conduits may include a conduit adapter and a conduit collar. The conduit adapter may include a housing, a bayonet connector, and a support member connecting the housing and the bayonet connector. The support member has an aperture that permits fluid communication through the support member. One end of the conduit collar is sized for insertion into the housing, and a second end is adapted to receive a first multi-lumen conduit. The housing also is adapted to receive a second multi-lumen conduit. The bayonet connector engages a primary lumen of the first multi-lumen conduit and the second multi-lumen conduit such that the primary lumen of the second multi-lumen conduit fluidly communicates with the primary lumen of the first multi-lumen conduit. The conduit adapter and the conduit collar are capable of 360 degree rotation relative to each other about a common axis.

Abstract: An apparatus for connecting multi-lumen conduits may include a conduit adapter and a conduit collar. The conduit adapter may include a housing, a bayonet connector, and a support member connecting the housing and the bayonet connector. The support member has an aperture that permits fluid communication through the support member. One end of the conduit collar is sized for insertion into the housing, and a second end is adapted to receive a first multi-lumen conduit. The housing also is adapted to receive a second multi-lumen conduit. The bayonet connector engages a primary lumen of the first multi-lumen conduit and the second multi-lumen conduit such that the primary lumen of the second multi-lumen conduit fluidly communicates with the primary lumen of the first multi-lumen conduit. The conduit adapter and the conduit collar are capable of 360 degree rotation relative to each other about a common axis.

Abstract: A class of compounds useful in pharmaceutical compositions and methods for treating or preventing cancer is described. The compounds' ability to inhibit RET kinase is quantified, i.e., their respective RET IC50 and EC50 values are described. One such compound, known as cyclobenzaprine and herein as SW-01, has been identified as RET-specific with an IC50 of 300 nM. SW-01 inhibits RET autophosphorylation and blocks the growth and transformation of thyroid cancer cell lines. It has been further tested in pancreatic cancer, breast cancer, and SCLC cell lines. The compounds show utility for inhibition of survival and proliferation of tumour cells.

Abstract: Synthetic peptides containing an ankyrin repeat-like motif or portion thereof and mimetics thereof which interact with synuclein-gamma (SNCG) and reduce SNCG-mediated resistance of SNCG-expressing cancer cells to treatment with anticancer drugs or inhibit tumorigenesis and cancer cell proliferation are provided. Compositions containing these peptides, portions thereof or mimetics thereof are also provided. Methods for use of these peptides or portions thereof, compositions, and mimetics thereof in potentiating efficacy of anticancer drugs, in particular microtubule inhibitors and hormonal cancer therapies, and in treating cancer are also provided.