Patents by Inventor Vincent A. Boyd
Vincent A. Boyd has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11787768Abstract: In one aspect, compounds and compositions that modulate a bromodomain and methods of making and using same are disclosed. The disclosed compounds and compositions can be useful for disorders associated with inhibition of a bromodomain such as, for example, cancer. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.Type: GrantFiled: March 4, 2021Date of Patent: October 17, 2023Assignee: ST. JUDE CHILDREN'S RESEARCH HOSPITALInventors: R. Kip Guy, P Jake Slavish, William Robert Shadrick, Brandon M. Young, Vincent A. Boyd, Nagakumar Bharatham, Jeanine E. Price, Anang Shelat
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Publication number: 20210188777Abstract: In one aspect, compounds and compositions that modulate a bromodomain and methods of making and using same are disclosed. The disclosed compounds and compositions can be useful for disorders associated with inhibition of a bromodomain such as, for example, cancer. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.Type: ApplicationFiled: March 4, 2021Publication date: June 24, 2021Inventors: R. Kip Guy, P. Jake Slavish, William Robert Shadrick, Brandon M. Young, Vincent A. Boyd, Nagakumar Bharatham, Jeanine E. Price, Anang Shelat
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Patent number: 11028051Abstract: In one aspect, compounds and compositions that modulate a bromodomain and methods of making and using same are disclosed. The disclosed compounds and compositions can be useful for disorders associated with inhibition of a bromodomain such as, for example, cancer. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.Type: GrantFiled: December 12, 2017Date of Patent: June 8, 2021Assignee: St. Jude Children's Research HospitalInventors: R. Kip Guy, P. Jake Slavish, William Robert Shadrick, Brandon M. Young, Vincent A. Boyd, Nagakumar Bharatham, Jeanine E. Price, Anang Shelat
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Patent number: 10875875Abstract: Provided herein are compounds and pharmaceutical compositions of formula I where R1, R2, R3, R4, R5 and R6 are as described herein. Also provided pharmaceutically acceptable salts or stereoisomers of these compounds. In addition methods are provided for inhibiting the binding of an integrin to treat various pathophysiological conditions.Type: GrantFiled: April 26, 2017Date of Patent: December 29, 2020Assignee: Aviara Pharmaceuticals, Inc.Inventors: Ronald J. Biediger, Michele A. Benish, Lindsay Bonner Hardy, Vincent A. Boyd, Robert V. Market, Thomas P. Thrash, Brandon M. Young
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Publication number: 20200079739Abstract: In one aspect, compounds and compositions that modulate a bromodomain and methods of making and using same are disclosed. The disclosed compounds and compositions can be useful for disorders associated with inhibition of a bromodomain such as, for example, cancer. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.Type: ApplicationFiled: December 12, 2017Publication date: March 12, 2020Inventors: R. Kip Guy, P. Jake Slavish, William Robert Shadrick, Brandon M. Young, Vincent A. Boyd, Nagakumar Bharatham, Jeanine E. Price, Anang Shelat
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Publication number: 20180312523Abstract: Provided herein are compounds and pharmaceutical compositions of formula I where R1, R2, R3, R4, R5 and R6 are as described herein. Also provided pharmaceutically acceptable salts or stereoisomers of these compounds. In addition methods are provided for inhibiting the binding of an integrin to treat various pathophysiological conditions.Type: ApplicationFiled: April 26, 2017Publication date: November 1, 2018Applicant: Aviara Pharmaceuticals, Inc.Inventors: Ronald J. Biediger, Michele A. Benish, Lindsay Bonner Hardy, Vincent A. Boyd, Robert V. Market, Thomas P. Thrash, Brandon M. Young
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Patent number: 9328075Abstract: In one aspect, the invention relates to novel, broad-spectrum anti-viral, pyrimidinone compounds, methods of use, compositions and kits useful in treating and/or preventing influenza. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.Type: GrantFiled: May 5, 2012Date of Patent: May 3, 2016Assignee: St. Jude Children's Research HospitalInventors: Thomas R. Webb, Vincent A. Boyd
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Publication number: 20140079666Abstract: In one aspect, the invention relates to novel, broad-spectrum anti-viral, pyrimidinone compounds, methods of use, compositions and kits useful in treating and/or preventing influenza. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.Type: ApplicationFiled: May 5, 2012Publication date: March 20, 2014Applicant: ST. JUDE CHILDREN'S RESEARCH HOSPITALInventors: Thomas R. Webb, Vincent A. Boyd
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Patent number: 7868135Abstract: The present invention provides derivatives of lipopeptide antibiotics that display antimicrobial activity against microorganisms, methods and compounds for synthesizing such antimicrobial derivatives and analogues, and methods of using the compounds in a variety of contexts, including in the treatment and prevention of microbial infections.Type: GrantFiled: June 28, 2004Date of Patent: January 11, 2011Assignee: Biowest Therapeutics Inc.Inventors: Dale R. Cameron, Vincent A. Boyd, Richard A. Leese, William V. Curran, Donald B. Borders, Paulo W. M. Sgarbi, Shirley A. Wacowich-Sgarbi, Matthew Nodwell, Yuchen Chen, Qi Jia, Dominique Dugourd
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Publication number: 20100137199Abstract: The present invention provides Dab9 derivatives of amphomycin-type lipopeptide antibiotics that display antimicrobial activity against Gram-positive bacteria, methods and intermediates for synthesizing the compounds and methods of using the compounds in a variety of contexts, including in the treatment and prevention of infections.Type: ApplicationFiled: February 1, 2010Publication date: June 3, 2010Applicant: Migenix Inc.Inventors: Maria Fardis, Dale R. Cameron, Vincent A. Boyd
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Patent number: 7655623Abstract: The present invention provides Dab9 derivatives of amphomycin-type lipopepetide antibiotics that display antimicrobial activity against Gram-positive bacteria, methods and intermediates for synthesizing the compounds and methods of using the compounds in a variety of contexts, including in the treatment and prevention of infections.Type: GrantFiled: October 5, 2006Date of Patent: February 2, 2010Assignee: Migenix Inc.Inventors: Maria Fardis, Dale R. Cameron, Vincent A. Boyd
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Publication number: 20070167357Abstract: The present invention provides Dab9 derivatives of amphomycin-type lipopepetide antibiotics that display antimicrobial activity against Gram-positive bacteria, methods and intermediates for synthesizing the compounds and methods of using the compounds in a variety of contexts, including in the treatment and prevention of infections.Type: ApplicationFiled: October 5, 2006Publication date: July 19, 2007Inventors: Maria Fardis, Dale Cameron, Vincent Boyd
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Publication number: 20070021434Abstract: The present dislcosure provides amide-based, non-nucleoside compounds having antiviral activity against Hepacivirus, such as hepatitis C virus (HCV), methods and intermediates for synthesizing such compounds, and methods of using the compounds in a variety of contexts, including in the treatment and prevention of viral infections. The present dislcosure also provides methods for identifying amide-based, non-nucleoside compounds having antiviral activity.Type: ApplicationFiled: June 26, 2006Publication date: January 25, 2007Applicant: Migenix Inc.Inventors: Vincent Boyd, Dale Cameron, Qi Jia, Paulo Sgarbi, Shirley Wacowich-Sgarbi
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Patent number: 7125844Abstract: The present invention provides Dab9 derivatives of amphomycin-type lipopeptide antibiotics that display antimicrobial activity against Gram-positive bacteria, methods and intermediates for synthesizing such compounds, and methods of using the compounds in a variety of contexts, including in the treatment and prevention of infections.Type: GrantFiled: January 2, 2003Date of Patent: October 24, 2006Assignee: Migenix Inc.Inventors: Maria Fardis, Dale R. Cameron, Vincent A. Boyd
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Publication number: 20050153876Abstract: The present invention provides derivatives of lipopeptide antibiotics that display antimicrobial activity against microorganisms, methods and compounds for synthesizing such antimicrobial derivatives and analogues, and methods of using the compounds in a variety of contexts, including in the treatment and prevention of microbial infections.Type: ApplicationFiled: June 28, 2004Publication date: July 14, 2005Applicant: Migenix Inc.Inventors: Dale Cameron, Vincent Boyd, Richard Leese, William Curran, Donald Borders, Paulo Sgarbi, Shirley Wacowich-Sgarbi, Mathew Nodwell, Yuchen Chen, Qi Jia, Dominique Dugourd
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Publication number: 20040138107Abstract: The present invention provides Dab9 derivatives of amphomycin-type lipopeptide antibiotics that display antimicrobial activity against Gram-positive bacteria, methods and intermediates for synthesizing such compounds, and methods of using the compounds in a variety of contexts, including in the treatment and prevention of infections.Type: ApplicationFiled: January 2, 2003Publication date: July 15, 2004Applicant: Micrologix Biotech Inc.Inventors: Maria Fardis, Dale R. Cameron, Vincent A. Boyd
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Patent number: 6329378Abstract: Disclosed are pharmaceutical compositions comprising aryl and heteroaryl hydrazone, hydrazine and thiosemicarbazone derivatives of formulae I and II, and methods for using the compositions as antifungal agents. The invention also relates to novel aryl and heteroaryl hydrazone, hydrazine and thiosemicarbazone derivatives of formulae I and II, their preparation, to pharmaceutical compositions containing them, and to methods of using them to alleviate fungal infections.Type: GrantFiled: February 10, 2000Date of Patent: December 11, 2001Assignee: Anadys Pharmaceuticals, Inc.Inventors: Xiaodan Mei, Peng Wang, Andrei Caracoti, Pamela Mingo, Vincent Boyd, Robert Murray, Nicholas J. Sisti, Yi Bin Xiang, Shuhao Zhu, C. Richard Wobbe, Daniel Moore
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Patent number: 6274596Abstract: Disclosed are pharmaceutical compositions and formulations comprising benzoquinoline derivatives having the formula (I) to (V), wherein formula (I) is: X is selected from the group consisting of O, S, CH2, CH2-CH2, C═O or NRB; Y is C or N; R1, R2, R3 and R4 are independently selected from the group consisting of hydrogen, halogen, linear or branched chain lower alky, alkenyl, alkynyl, alkoxy or acyl; X-RA and R3, or R3 and R4, are optionally linked together to form a C3-C4 alkylene bridge, where X is CH2 or C═O; provided that: when X is NRB, then (a) RB is hydrogen, and RA is a linear or branched chain lower alkyl, aryl, heteroaryl, cycloalkyl or cycloalkenyl optionally interrupted by at least one heteroatom, said alkyl, alkenyl, alkynyl, aryl, heteroaryl, cycloalkyl or cycloalkenyl being optionally substituted singly or plurally by at least one of a linear or branched chain lower alkyl, alkenyl, alkynyl, acyl, alkoxy, or cycloalkyl optionally interrupted by at least one heterType: GrantFiled: October 6, 1999Date of Patent: August 14, 2001Assignee: Anadys Pharmaceuticals, Inc.Inventors: Kelvin Lam, Vincent Boyd, Yi Bin Xiang