Patents by Inventor Vincent Beuger

Vincent Beuger has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SHRNA-MEDIATED INHIBITION OF EXPRESSION OF ALPHA-1,6-FUCOSYLTRANSFERASE
    Publication number: 20110151513
    Abstract: The current invention comprises a method for producing a heterologous polypeptide with a reduced degree of fucose modification in a mammalian cell by cultivating the mammalian cell under conditions suitable for the expression of said heterologous polypeptide, and recovering the heterologous polypeptide from the mammalian cell or the culture, wherein in said mammalian cell the enzymatic activity of ?1,6-fucosyltransferase is reduced by means of an shRNA directed against ?1,6-fucosyltransferase mRNA.
    Type: Application
    Filed: December 1, 2010
    Publication date: June 23, 2011
    Inventors: Vincent Beuger, Helmut Burtscher, Christian Klein
  • SHRNA-MEDIATED INHIBITION OF EXPRESSION OF ALPHA 1,6-FUCOSYLTRANSFERASE
    Publication number: 20100028949
    Abstract: The current invention comprises a method for producing a heterologous polypeptide with a reduced degree of fucose modification in a mammalian cell by cultivating the mammalian cell under conditions suitable for the expression of said heterologous polypeptide, and recovering the heterologous polypeptide from the mammalian cell or the culture, wherein in said mammalian cell the enzymatic activity of ?1,6-fucosyltransferase is reduced by means of an shRNA directed against ?1,6-fucosyltransferase mRNA.
    Type: Application
    Filed: December 19, 2007
    Publication date: February 4, 2010
    Inventors: Vincent Beuger, Helmut Burtscher, Christian Klein
  • SELECTION METHOD
    Publication number: 20100015627
    Abstract: The current invention comprises a method for the selection of a mammalian cell by transfecting a mammalian cell with a nucleic acid comprising a part of a nucleic acid encoding a polypeptide that catalyzes an ?1,6-glycosidic bond formation between fucose and an asparagine-linked N-acetylglucosamine and cultivating the transfected mammalian cell in the presence of Lens culinaris agglutinin (LCA) and selecting a mammalian cell viable under these conditions.
    Type: Application
    Filed: December 19, 2007
    Publication date: January 21, 2010
    Inventors: Vincent Beuger, Helmut Burtscher, Christian Klein