Abstract: A method and system are disclosed for generating a machine learning model for automatic classification of radiographic images acquired by various acquisition protocols. The method includes the steps of: providing a plurality of radiographic images, detecting and segmenting in each of the radiographic image at least one regions of interest (ROI) as reference ROI, measuring at least one radiomic feature per reference ROI, identifying valid reference ROIs based on the measured radiomics values, and clustering the measured radiomics values of valid reference ROIs into at least two reference clusters according to a set of characteristics of image acquisition. A method and system are disclosed for classifying radiographic images by applying a machine learning model generated for automatic classification of radiographic images.