Abstract: In the method of manufacturing a strip (8) of rubber for vehicle tires: a strip (8) of rubber is formed; the strip is cooled with water; residual water (40) on the surface of the strip is heated from the exterior of the strip and/or this water is replaced by hotter water; and the water present on the surface of the strip is eliminated.

Abstract: A method of preparing an amorphous film of lithiated metal sulfide or oxysulfide of formula Li?M(O1-?S?)? using a lithiated target material: M being advantageously selected from the group comprising Al, Ti, V, Cr, Mn, Fe, Co, Ni, Cu, Zn, Ge, Zr, Nb, Mo, Ag, Cd, In, Sn, Sb, Ta, W, Pb, Bi, and mixtures thereof; and ??0.5; 1????; 2??/???.

Abstract: The present invention relates to a process for synthesizing a multifunctional compound, including the reaction of a compound of formula (II) with atmospheric or molecular oxygen, in the presence of at least one aldehyde of formula (III), and optionally in the presence of at least one catalyst or at least one radical initiator; wherein: R10, R20, R30, R40, R50, L2, R60, R7, R8, and R9 are as described in the claims. The invention also relates to the use of these compounds as monomers for the preparation of polyurethane. The invention also relates to the use of these compounds as monomers of polymers or of biopolymers.

Abstract: A closed loop location detection system for use in monitoring simultaneously the presence or absence of objects in at least two locations, comprises at least one detectable element per location and adapted to be associated with a respective object to be monitored, and at least one detecting device adapted to detect the detectable elements of the objects and so determine whether objects are present in, or absent from, all of the locations being monitored. Means are provided for causing an object to be fed to a location determined to be devoid of objects by the detecting device. Typically, the closed loop location detection system uses RFID technology, e.g. the detection device comprises at least one antenna and the detectable element comprising at least one RF tag. There may be provided one such antenna for each location to be monitored, whereby for a given location, a respective antenna detects the presence or absence of a respective tag thereby determining whether an object is present in this given location.

Abstract: In the method of manufacturing a strip (8) of rubber for vehicle tires: a strip (8) of rubber is formed; the strip is cooled with water; residual water (40) on the surface of the strip is heated from the exterior of the strip and/or this water is replaced by hotter water; and the water present on the surface of the strip is eliminated.

Abstract: The present invention relates to a process for synthesizing a multifunctional compound, including the reaction of a compound of formula (II) with atmospheric or molecular oxygen, in the presence of at least one aldehyde of formula (III), and optionally in the presence of at least one catalyst or at least one radical initiator; wherein: R10, R20, R30, R40, R50, L2, R60, R7, R8, and R9 are as described in the claims. The invention also relates to the use of these compounds as monomers for the preparation of polyurethane. The invention also relates to the use of these compounds as monomers of polymers or of biopolymers.

Abstract: A closed-loop receptacle setup verification and traceability system for use in automatically detecting the presence or absence of a components receptacle at a location is presented, such receptacles comprising components reels, components bearing trays or racks, or other such receptacles for bearing and providing components for components processing and/or manipulation. The system is further for automatically identifying the detected receptacles and validating their use at respective detecting locations based on components parameters identifiably associated therewith. The system is still further for tracking and monitoring such receptacles from one detecting location to another optionally updating components parameters associated therewith as needed.

Abstract: The prodrug of the invention is a modified form of a therapeutic agent and comprises a therapeutic agent, an oligopeptide, a stabilizing group and, optionally, a linker group. The prodrug is cleavable by the enzyme Thimet oligopeptidase, or TOP. Also disclosed are methods of designing prodrugs by utilizing TOP-cleavable sequences within the conjugate and methods of treating patients with prodrugs of the invention.

Abstract: The product of the invention is a modified form of a therapeutic agent and comprises a therapeutic agent, an oligopeptide having a plasmin peptide substrate of 2-4 amino acids and mono- or di-peptide linkage, a stabilizing group and, optionally, a linker group. The prodrug is cleavable by plasmin. Also disclosed are methods of making and using the prodrug compounds.

Abstract: The prodrug of the invention is a modified form of a therapeutic agent and comprises a therapeutic agent, an oligopeptide of three amino acids, a stabilizing group and, optionally, a linker group. The prodrug is cleavable by a trouase enzyme such as Thimet oligopeptidase. Also disclosed are methods of making and using the prodrug compounds.

Abstract: A closed loop location detection system for use in monitoring simultaneously the presence or absence of objects in at least two locations, comprises at least one detectable element per location and adapted to be associated with a respective object to be monitored, and at least one detecting device adapted to detect the detectable elements of the objects and so determine whether objects are present in, or absent from, all of the locations being monitored. Means are provided for causing an object to be fed to a location determined to be devoid of objects by the detecting device. Typically, the closed loop location detection system uses RFID technology, e.g. the detection device comprises at least one antenna and the detectable element comprising at least one RF tag. There may be provided one such antenna for each location to be monitored, whereby for a given location, a respective antenna detects the presence or absence of a respective tag thereby determining whether an object is present in this given location.

Abstract: The present invention relates to a method for the preparation of a compound of formula (I) or pharmaceutically acceptable salts thereof and intermediates thereof, comprising the steps of: a) halogenating a compound of formula (II), resulting in compound of formula (IIa), b) reacting a compound of formula (IIa) at its 14 position with the thiol moiety of a peptide of formula (III), optionally in the presence of a suitable linker, to obtain said compound of formula (I), wherein R1 represents OH, NH2 or NH-peptide; R2 represents H or —CO-peptide; R3 represents OCH3, OH or H; R4 represents H, or COCF3; R5 represents OH, O-tetrahydropyranyl or H; R6 represents OH or H; R7 represents H, OH, OCO(CH2)3CH3 or OCOCH(OC2H5)2; R8 represents OH or H; R9 represents OH or H; R10 represents a halogen and L is an optional suitable linker arm.

Abstract: A closed loop location detection system for use in monitoring simultaneously the presence or absence of objects in at least two locations, comprises at least one detectable element per location and adapted to be associated with a respective object to be monitored, and at least one detecting device adapted to detect the detectable elements of the objects and so determine whether objects are present in, or absent form, all of the locations being monitored. Means are provided for causing an object to be fed to a location determined to be devoid of objects by the detecting device. Typically, the closed loop location detection system uses RFID technology, e.g. the detection device comprises at least one antenna and the detectable element comprising at least one RF tag. There may be provided one such antenna for each location to be monitored, whereby for a given location, a respective antenna detects the presence or absence of a respective tag thereby determining whether an object is present in this given location.

Abstract: This invention relates to the field of antibody-drug conjugates, and more particularly antibody-drug conjugates that are intended for the treatment and/or diagnosis of diseases such as tumors and/or inflammatory reactions.

Abstract: The prodrug of the invention is a modified form of a therapeutic agent and comprises a therapeutic agent, an oligopeptide, a stabilizing group and, optionally, a linker group. The prodrug is cleavable by the enzyme Thimet oligopeptidase, or TOP. Also disclosed are methods of designing prodrugs by utilizing TOP-cleavable sequences within the conjugate and methods of treating patients with prodrugs of the invention.

Abstract: The product of the invention is a modified form of a therapeutic agent and comprises a therapeutic agent, an oligopeptide having a plasmin peptide substrate of 2-4 amino acids and mono- or di-peptide linkage, a stabilizing group and, optionally, a linker group. The prodrug is cleavable by plasmin. Also disclosed are methods of making and using the prodrug compounds.

Abstract: A closed-loop receptacle setup verification and traceability system for use in automatically detecting the presence or absence of a components receptacle at a location is presented, such receptacles comprising components reels, components bearing trays or racks, or other such receptacles for bearing and providing components for components processing and/or manipulation. The system is further for automatically identifying the detected receptacles and validating their use at respective detecting locations based on components parameters identifiably associated therewith. The system is still further for tracking and monitoring such receptacles from one detecting location to another optionally updating components parameters associated therewith as needed.

Abstract: The prodrug of the invention is a modified form of a therapeutic agent and comprises a therapeutic agent, an oligopeptide, a stabilizing group and, optionally, a linker group. The prodrug is cleavable by the enzyme Thimet oligopeptidase, or TOP. Also disclosed are methods of designing prodrugs by utilizing TOP-cleavable sequences within the conjugate and methods of treating patients with prodrugs of the invention.

Abstract: The product of the invention is a modified form of a therapeutic agent and comprises a therapeutic agent, an oligopeptide having a plasmin peptide substrate of 2-4 amino acids and mono- or di-peptide linkage, a stabilizing group and, optionally, a linker group. The prodrug is cleavable by plasmin. Also disclosed are methods of making and using the prodrug compounds.

Abstract: The prodrug of the invention is a modified form of a therapeutic agent and comprises a therapeutic agent, an oligopeptide of three amino acids, a stabilizing group and, optionally, a linker group. The prodrug is cleavable by a trouase enzyme such as Thimet oligopeptidase. Also disclosed are methods of making and using the prodrug compounds.